SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_001142269 |
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Gene Symbol: | GGCX |
Description: | Homo sapiens gamma-glutamyl carboxylase (GGCX), transcript variant 1, mRNA. |
Gene Location: | chr2(-):85771977-85788657 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85545408T>C | COSN1861378 | RK035_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85545962A>T | 9_83516 | CRC-8-Tumor | Colorectal adenocarcinoma | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4668-3p |
ggtctgcGGATTTTCtaca |
5 |
GAAAAUCC | m8a | Disrupted | 0.159 | no TS |
0.05 |
|
hsa-miR-548ac |
ggtctgcGGTTTTTctaca |
6 |
CAAAAACC | m7b | Created | 0.25 | 0.396 |
-0.55 |
|
hsa-miR-548at-3p |
ggtctgCGGTTTTtctaca |
2 |
CAAAACCG | m7b | Created | 0.043 | 0.071 |
-2.42 |
|
hsa-miR-548d-3p |
ggtctgcGGTTTTTctaca |
6 |
CAAAAACC | m7b | Created | 0.294 | 0.449 |
-1.12 |
|
hsa-miR-548h-3p |
ggtctgcGGTTTTTctaca |
6 |
CAAAAACC | m7b | Created | 0.274 | 0.42 |
-3.52 |
|
hsa-miR-548z |
ggtctgcGGTTTTTctaca |
6 |
CAAAAACC | m7b | Created | 0.274 | 0.42 |
-3.52 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85547491A>G | COSN5961751 | RK149_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-2110 |
cccTTCCCCAAactgttag |
1 |
UUGGGGAA | m8a | Disrupted | 0.034000 | -0.010000 | No effect | |
hsa-miR-3150a-3p |
ccctTCCCCAaactgttag |
1 |
CUGGGGAG | m6b | Disrupted | 0.006000 | -0.009000 | No effect | |
hsa-miR-4260 |
cccttCCCCAAactgttag |
2 |
CUUGGGGC | m6b | Disrupted | -0.320000 | -0.330000 | No effect | |
hsa-miR-450a-3p |
ccctTCCCCAAactgttag |
2 |
AUUGGGGA | m7b | Disrupted | -0.166000 | -0.141000 |
-0.070000 |
|
hsa-miR-4725-3p |
ccCTTCCCCAaactgttag |
1 |
UGGGGAAG | m8a | (m8a->m7b) | -0.017000 | 0.022000 |
-0.140000 |
|
hsa-miR-542-5p |
ccctTCCCCGAactgttag |
0 | UCGGGGAU | m7a | Created | no TS | -0.094000 |
-0.020000 |
|
hsa-miR-5572 |
cccttCCCCAAactgttag |
2 |
GUUGGGGU | m6b | Disrupted | -0.113000 | -0.116000 |
0.020000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85547620T>G | COSN14599451 | 8014964 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-196a-3p |
agaagatacGTTGCCacta |
0 | CGGCAACA | m6b | Created | no TS | -0.024000 |
-5.180000 |
|
hsa-miR-3973 |
agaagaTACTTTGccacta |
1 |
ACAAAGUA | m7b | Disrupted | 0.179000 | 0.101000 |
0.010000 |
|
hsa-miR-548l |
agaagATACTTTgccacta |
2 |
AAAAGUAU | m7b | Disrupted | 0.529000 | 0.353000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85548341A>C | COSN10009473 | C0051T | [kidney][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-5590-3p |
ttattCTTTATTattgaat |
0 | AAUAAAGU | m7a | Disrupted | NA | NA |
0.020000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85549048A>T | COSN1861380 | RK027_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-5010-3p |
atgcACACAAAgtaattta |
1 |
UUUUGUGU | m7b | Disrupted | -0.023000 | no TS | No effect | |
hsa-miR-599 |
atgcACACAAagtaattta |
1 |
GUUGUGUC | m6b | Disrupted | -0.016000 | no TS | No effect | |
hsa-miR-5010-3p |
atgcACACAAAgtaattta |
1 |
UUUUGUGU | m7b | Disrupted | -0.023000 | no TS | No effect | |
hsa-miR-599 |
atgcACACAAagtaattta |
1 |
GUUGUGUC | m6b | Disrupted | -0.016000 | no TS | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85549140A>G | COSN8896985 | SS6003109 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-145-3p |
gtaattttcGGAATCactg |
15 |
GGAUUCCU | m6b | Created | -0.390000 | -0.467000 |
-0.020000 |
|
hsa-miR-4766-5p |
gtaatTTTCAGAatcactg |
0 | UCUGAAAG | m7a | Disrupted | 0.068000 | 0.053000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr2:g.85549782C>T | COSN15229202 | LP6005334-DNA_E03 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-382-5p |
agattACAACTTagaggaa |
0 | GAAGUUGU | m7b | Disrupted | -0.271000 | no TS |
0.540000 |
|
hsa-miR-4799-5p |
agattacaATTTAGAggaa |
0 | AUCUAAAU | m7b | Created | 0.032000 | -0.028000 |
-3.050000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr2:g.85549918G>A | COSN1861382 | RK141_C01 | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-500a-3p |
ccagatgttAGGTGCAgat |
0 | AUGCACCU | m7b | (m6b->m7b) | no TS | -0.260000 |
-1.040000 |
hsa-miR-500a-3p |
ccagatgttAGGTGCAgat |
0 | AUGCACCU | m7b | (m6b->m7b) | no TS | -0.260000 |
-1.040000 |
hsa-miR-500a-3p |
ccagatgttAGGTGCAgat |
0 | AUGCACCU | m7b | (m6b->m7b) | no TS | -0.26 |
-1.04 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
85545310 | rs3209939 | A | A |
hsa-miR-1251-3p hsa-miR-302a-3p hsa-miR-302b-3p hsa-miR-302c-3p hsa-miR-302d-3p hsa-miR-302e hsa-miR-372-3p hsa-miR-373-3p hsa-miR-4260 hsa-miR-450a-2-3p hsa-miR-520a-3p hsa-miR-520b hsa-miR-520c-3p hsa-miR-520d-3p hsa-miR-520e hsa-miR-520f-3p hsa-miR-5572 |
3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
cccCAAAGCActt ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT CCCCAAAgcactt CCCCAAAgcactt ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT ccccaaAGCACTT ccccaAAGCACTt CCCCAAAgcactt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N N N N N N N N |
-0.052 -0.13 -0.13 -0.13 -0.13 -0.139 -0.149 -0.139 -0.177 -0.1 -0.139 -0.139 -0.139 -0.139 -0.13 -0.155 -0.116 |
G |
hsa-miR-3189-3p hsa-miR-33b-3p hsa-miR-4312 hsa-miR-515-3p hsa-miR-519e-3p |
2 2 3 2 2 |
cCCCAAGGcactt ccccaAGGCACTt cccCAAGGCActt ccccaAGGCACTt ccccaAGGCACTt |
Created Created Created Created Created |
N N N N N |
-0.132 -0.199 -0.103 -0.199 -0.218 |
|||
85547123 | rs118153916 | T | T |
hsa-miR-3153 hsa-miR-4422 hsa-miR-5584-5p hsa-miR-6733-5p hsa-miR-6739-5p hsa-miR-6873-5p |
1 1 2 1 1 1 |
atgCTTTCCCtct ATGCTTTccctct atgcTTTCCCTct atgCTTTCCCtct atgCTTTCCCtct atgcttTCCCTCT |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
0.069 0.146 0.129 0.069 0.069 0.026 |
C |
hsa-miR-4271 hsa-miR-4725-3p hsa-miR-6780b-5p hsa-miR-6783-5p hsa-miR-6828-5p |
1 1 1 2 1 |
atgCTTCCCCtct atgCTTCCCCtct atgCTTCCCCtct atgcTTCCCCTct aTGCTTCCcctct |
Created Created Created Created Created |
N N N N N |
0.025 0.006 -0.022 0.084 0.012 |
|||
85547490 | rs148903181 | A | A |
hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-4260 hsa-miR-450a-2-3p hsa-miR-5572 hsa-miR-6740-5p hsa-miR-6763-5p hsa-miR-6810-5p hsa-miR-6857-5p |
1 1 1 1 1 1 1 1 1 |
TCCCCAAactgtt TCCCCAAactgtt tCCCCAAActgtt TCCCCAAActgtt tCCCCAAActgtt tcCCCAAACtgtt TCCCCAAactgtt TCCCCAAactgtt TCCCCAAactgtt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N |
-0.027 0.015 0.01 -0.025 0.003 0.032 0.015 -0.012 -0.014 |
G |
hsa-miR-132-3p hsa-miR-212-3p hsa-miR-4667-5p hsa-miR-4700-5p hsa-miR-622 hsa-miR-637 hsa-miR-7155-5p hsa-miR-8089 |
5 5 1 1 4 1 1 1 |
tccccaGACTGTT tccccaGACTGTT TCCCCAGActgtt TCCCCAGActgtt tcccCAGACTGtt tCCCCAGActgtt tCCCCAGActgtt TCCCCAGActgtt |
Created Created Created Created Created Created Created Created |
N N N N N N N N |
0.004 -0.003 -0.041 -0.052 0.041 -0.01 -0.023 -0.052 |
|||
85549709 | rs72843839 | G | |||||||
A |
hsa-miR-4289 hsa-miR-4711-3p hsa-miR-592 hsa-miR-599 |
0 |
ttagaCACAATGt ttAGACACAatgt ttaGACACAAtgt ttaGACACAAtgt |
Created Created Created Created |
N N N N |
-0.151 -0.119 -0.119 -0.164 |