SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000157
Gene Symbol: GBA
Description: Homo sapiens glucosidase, beta, acid (GBA), transcript variant 1, mRNA.
Gene Location: chr1(-):155204238-155211069
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr1:g.155234903G>A COSN5265403 SNUH_G25_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146b-3p gagggcacaACAGGGCcag
0 UGCCCUGU m7b (m6b->m7b) no TS -0.219000 No effect
hsa-miR-3173-5p gagggcacaGCAGGGCcag
4
UGCCCUGC m7b (m7b->m6b) -0.257000 no TS 0.690000
hsa-miR-370 gagggcaCAGCAGGgccag
4
GCCUGCUG m7b Disrupted -0.136000 no TS 0.860000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
155234903 rs144123706 G G hsa-miR-3173-5p
hsa-miR-370-3p
hsa-miR-6799-3p
hsa-miR-6889-3p
hsa-miR-6893-3p
4
4
4
2
4
ggcacaGCAGGGC
ggcaCAGCAGGgc
ggcacaGCAGGGC
GGCACAGcagggc
ggcaCAGCAGGgc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
-0.257
-0.136
-0.257
-0.191
-0.154
A hsa-miR-146b-3p
hsa-miR-550b-2-5p
4
2
ggcacaACAGGGC
GGCACAAcagggc
Created
Created
N
N
-0.219
-0.166

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