| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_021904 |
|---|---|
| Gene Symbol: | GABBR1 |
| Description: | Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 1, mRNA. |
| Gene Location: | chr6(-):29570004-29600962 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.29602941C>T | COSN9779887 | AOCS-086-3-2 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3150b-3p |
tgcatccTCTCCTCtcctg |
0 | UGAGGAGA | m7b | Created | -0.074000 | -0.097000 |
-0.030000 |
|
| hsa-miR-4784 |
tgcatccTCTCCTCtcctg |
0 | UGAGGAGA | m7b | Created | -0.071000 | -0.103000 |
-0.710000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.29603266C>T | COSN2382689 | TCGA-A5-A0VQ-01 | [endometrium][NS][carcinoma][endometrioid_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-103a-3p |
ctgctcacATGCTGCctcc |
0 | AGCAGCAU | m7b | Created | no TS | -0.119000 |
-6.290000 |
|
| hsa-miR-107 |
ctgctcacATGCTGCctcc |
0 | AGCAGCAU | m7b | Created | no TS | -0.119000 |
-7.490000 |
|
| hsa-miR-3607-5p |
ctgcTCACATGCtgcctcc |
5 |
GCAUGUGA | m8a | Created | -0.123000 | -0.187000 |
-0.020000 |
|
| hsa-miR-885-3p |
ctgctcacaCGCTGCCTcc |
2 |
AGGCAGCG | m8a | (m8a->m7a) | -0.239000 | no TS |
0.710000 |
|
| hsa-miR-103a-3p |
ctgctcacATGCTGCctcc |
0 | AGCAGCAU | m7b | Created | no TS | -0.119 |
-6.29 |
|
| hsa-miR-107 |
ctgctcacATGCTGCctcc |
0 | AGCAGCAU | m7b | Created | no TS | -0.119 |
-7.49 |
|
| hsa-miR-3607-5p |
ctgcTCACATGCtgcctcc |
0 | GCAUGUGA | m8a | Created | -0.123 | -0.187 |
-0.02 |
|
| hsa-miR-885-3p |
ctgctcacaCGCTGCCTcc |
0 | AGGCAGCG | m8a | (m8a->m7a) | -0.239 | no TS |
0.71 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.29603351T>A | COSN9779888 | AOCS-112-1-2 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-539-5p |
aacagacctATTTCTCtct |
2 |
GGAGAAAU | m7b | (m6b->m7b) | 0.003000 | -0.073000 |
0.020000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr6:g.29603517G>T | COSN1083970 | TCGA-D1-A103-01 | [endometrium][NS][carcinoma][endometrioid_carcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-193a-3p |
gacaGGCCAGTagggggag |
2 |
AACUGGCC | m7b | Disrupted | -0.433000 | no TS |
1.900000 |
| hsa-miR-193b-3p |
gacaGGCCAGTagggggag |
2 |
AACUGGCC | m7b | Disrupted | -0.433000 | no TS |
11.990000 |
| hsa-miR-3176 |
gacAGGCCAGTagggggag |
5 |
ACUGGCCU | m8a | Disrupted | -0.162000 | no TS |
0.300000 |
| hsa-miR-3922-3p |
gacAGGCCAGtagggggag |
5 |
UCUGGCCU | m7b | (m7b->m6c) | -0.153000 | no TS |
6.200000 |
| hsa-miR-5197-5p |
gacagGCCATTagggggag |
0 | CAAUGGCA | m6b | Created | no TS | -0.069000 |
-14.490000 |
| hsa-miR-892b |
gacagGCCAGTagggggag |
3 |
CACUGGCU | m6b | Disrupted | -0.122000 | no TS |
12.310000 |
| hsa-miR-193a-3p |
gacaGGCCAGTagggggag |
0 | AACUGGCC | m7b | Disrupted | -0.433 | no TS |
1.9 |
| hsa-miR-193b-3p |
gacaGGCCAGTagggggag |
0 | AACUGGCC | m7b | Disrupted | -0.433 | no TS |
11.99 |
| hsa-miR-3176 |
gacAGGCCAGTagggggag |
0 | ACUGGCCU | m8a | Disrupted | -0.162 | no TS |
0.3 |
| hsa-miR-3922-3p |
gacAGGCCAGtagggggag |
0 | UCUGGCCU | m7b | (m7b->m6c) | -0.153 | no TS |
6.2 |
| hsa-miR-5197-5p |
gacagGCCATTagggggag |
0 | CAAUGGCA | m6b | Created | no TS | -0.069 |
-14.49 |
| hsa-miR-892b |
gacagGCCAGTagggggag |
0 | CACUGGCU | m6b | Disrupted | -0.122 | no TS |
12.31 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 29603265 | rs9257923 | G | G |
hsa-miR-885-3p |
2 |
tcacaCGCTGCCt |
Disrupted |
N |
-0.239 |
| A |
hsa-miR-2682-5p hsa-miR-34a-5p hsa-miR-34b-5p hsa-miR-34c-5p hsa-miR-4302 hsa-miR-449a hsa-miR-449b-5p hsa-miR-449c-5p hsa-miR-6499-3p hsa-miR-6818-5p hsa-miR-6867-5p |
2 2 2 2 1 2 2 2 1 1 1 |
tcacacACTGCCT tcacaCACTGCCt tcacacACTGCCT tcacaCACTGCCt tcaCACACTGcct tcacaCACTGCCt tcacaCACTGCCt tcacacACTGCCT tcacACACTGCct TCACACActgcct tCACACACtgcct |
Created Created Created Created Created Created Created Created Created Created Created |
N N N N N N N N N N N |
-0.117 -0.197 -0.117 -0.197 -0.118 -0.178 -0.178 -0.107 -0.084 -0.07 -0.099 |
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| 29603521 | rs143955994 | G | G |
hsa-miR-193a-3p hsa-miR-193b-3p hsa-miR-214-5p hsa-miR-3176 hsa-miR-3922-3p hsa-miR-6735-3p hsa-miR-6748-3p hsa-miR-892b |
3 3 5 5 5 4 5 6 |
ggacaGGCCAGTA ggacaGGCCAGTA gGACAGGCcagta ggacAGGCCAGta ggacAGGCCAGta ggACAGGCCAgta GGACAGGccagta ggacagGCCAGTA |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N |
-0.433 -0.433 -0.157 -0.162 -0.153 -0.423 -0.204 -0.122 |
| A |
hsa-miR-3663-5p hsa-miR-4527 hsa-miR-6503-5p hsa-miR-6753-3p hsa-miR-7107-3p |
5 4 4 4 4 |
ggacAGACCAGta ggaCAGACCAgta ggaCAGACCAgta ggACAGACCAgta ggACAGACCAgta |
Created Created Created Created Created |
N N N N N |
-0.115 -0.127 -0.131 -0.332 -0.321 |