SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_138457
Gene Symbol: FOXP4
Description: Homo sapiens forkhead box P4 (FOXP4), transcript variant 1, mRNA.
Gene Location: chr6(+):41514163-41570122
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr6:g.41599783G>A COSN7883038 8031704 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-615-5p gccaggctGGACCCCggct
1
GGGGGUCC m7b Disrupted -0.093000 -0.005000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.41600484T>C COSN1333090 HCC85T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5093 ctccttggaCATTTCCcaa
0 AGGAAAUG m7b (m6c->m7b) no TS 0.103000 No effect
hsa-miR-5093 ctccttggaCATTTCCcaa
0 AGGAAAUG m7b (m6c->m7b) no TS 0.103 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.41601557T>C ICGC_DB0BC824-2A78-11E2-B303-24FD496BB9B8 CPCG_0103_Pr_P_P6 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1827 ctgcaacctCTGCCTCcca
0 UGAGGCAG m7b (m6c->m7b) -0.277 -0.349 -0.09
hsa-miR-2467-3p ctgcaaCCTCTGCctccca
0 AGCAGAGG m7b Created -0.236 -0.332 No effect
hsa-miR-377-5p ctgCAACCTCTgcctccca
0 AGAGGUUG m8a Created no TS -0.007 -1.3
hsa-miR-4257 ctgcaACCTCTGcctccca
0 CCAGAGGU m7b Created no TS -0.047 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.41601680T>G COSN2162176 RK184_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376c tcTCTATGTTggtcaggct
1
AACAUAGA m8a (m8a->m7a) -0.021000 0.006000 2.270000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
41599822 rs71558753 C C hsa-miR-2467-3p
hsa-miR-3158-5p
hsa-miR-3678-3p
hsa-miR-4418
hsa-miR-509-3-5p
hsa-miR-509-5p
hsa-miR-6758-5p
hsa-miR-6856-5p
2
2
2
3
3
3
2
2
gcctCTCTGCAgt
gcctcTCTGCAGt
gcctCTCTGCAgt
gcctctCTGCAGT
gcctctCTGCAGT
gcctctCTGCAGT
gCCTCTCTgcagt
gCCTCTCTgcagt
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
0.009
0.025
0.002
-0.025
-0.025
-0.025
0.034
0.034
T hsa-miR-518a-5p
hsa-miR-527
hsa-miR-583
2
2
2
gcctCTTTGCAgt
gcctCTTTGCAgt
gCCTCTTTgcagt
Created
Created
Created
N
N
N
0.038
0.038
0.121
41599889 rs73733287 C C hsa-miR-6087
21
cttgcCCGCCTCt
Disrupted
N
-0.059
T hsa-miR-1827
hsa-miR-4742-5p
hsa-miR-6808-5p
hsa-miR-6893-5p
hsa-miR-940
21
1
3
3
3
cttgcCTGCCTCt
cTTGCCTGcctct
cttgCCTGCCTct
cttgCCTGCCTct
cttgCCTGCCTct
Created
Created
Created
Created
Created
N
N
N
N
N
0.026
0.056
-0.012
-0.012
0.034
41602100 rs3747746 A A hsa-miR-1255a
hsa-miR-1255b-5p
hsa-miR-3681-5p
hsa-miR-3691-5p
hsa-miR-6744-5p
hsa-miR-6849-5p
hsa-miR-759
1
1
1
1
1
1
2
TCATCCActctgc
TCATCCActctgc
tcATCCACTctgc
tCATCCACtctgc
TCATCCActctgc
tcATCCACTctgc
tcatcCACTCTGc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
-0.064
-0.064
-0.077
-0.208
-0.078
-0.114
-0.082
C hsa-miR-2467-3p
hsa-miR-5187-5p
2
1
tcatccCCTCTGC
TCATCCCctctgc
Created
Created
N
N
-0.198
-0.155
41602105 rs184271178 G G hsa-miR-2467-3p
hsa-miR-3158-5p
hsa-miR-3678-3p
hsa-miR-759
1
1
1
2
caCTCTGCAggcc
cacTCTGCAGgcc
caCTCTGCAggcc
CACTCTGcaggcc
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
-0.061
-0.078
-0.088
-0.082
A hsa-miR-4732-5p
hsa-miR-5586-3p
hsa-miR-6735-3p
hsa-miR-6832-5p
1
2
3
1
caCTCTACAggcc
CACTCTAcaggcc
cactctACAGGCC
caCTCTACAggcc
Created
Created
Created
Created
N
N
N
N
-0.064
-0.079
-0.175
-0.043

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