SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_004473
Gene Symbol: FOXE1
Description: Homo sapiens forkhead box E1 (thyroid transcription factor 2) (FOXE1), mRNA.
Gene Location: chr9(+):100615536-100618997
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr9:g.97855197G>T COSN14724833 CHC322T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4672 taggcaccCTGTGTActct
 0 UUACACAG m7b Created no TS -0.024000 -2.240000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.97855394C>T COSN8519684 3676_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3929 cagttTCAGCCTtccatgt
 1
 GAGGCUGA m7b Disrupted -0.331000 -0.171000 No effect
hsa-miR-4419b cagttTCAGCCTtccatgt
 1
 GAGGCUGA m7b Disrupted -0.350000 -0.171000 No effect
hsa-miR-4478 cagttTCAGCCTtccatgt
 1
 GAGGCUGA m7b Disrupted -0.323000 -0.153000 No effect
hsa-miR-4499 cagttTCAGTCTTccatgt
 4
 AAGACUGA m8a Created -0.063000 -0.200000 No effect
hsa-miR-7-5p cagtttcaGTCTTCCAtgt
 7
 UGGAAGAC m8a Created 0.011000 -0.309000 -3.710000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.97855644A>G COSN6371893 RK205_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3199 cagcactcCAGTCCCatca
 0 AGGGACUG m7b Disrupted -0.337000 -0.088000 -0.450000
hsa-miR-3649 cagcactccGGTCCCatca
 0 AGGGACCU m6b Created no TS -0.149000 -5.930000
hsa-miR-365a-5p cagcactccAGTCCCatca
 2
 AGGGACUU m6b Disrupted -0.292000 -0.197000 0.110000
hsa-miR-365b-5p cagcactccAGTCCCatca
 2
 AGGGACUU m6b Disrupted -0.292000 -0.197000 0.030000
hsa-miR-4515 cagcactCCAGTCCcatca
 4
 AGGACUGG m7b Disrupted -0.327000 -0.170000 0.850000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.97855661C>T COSN5240529 SS6003308 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4766-5p cacctgaaCTTTCAGtctc
 6
 UCUGAAAG m7b Created -0.299000 -0.316000 -2.400000
hsa-miR-5000-5p cacCTGAACTttcagtctc
 2
 CAGUUCAG m7b (m6b->m7b) -0.018000 -0.063000 No effect
hsa-miR-4766-5p cacctgaaCTTTCAGtctc
 6
 UCUGAAAG m7b Created -0.299000 -0.316000 -2.400000
hsa-miR-5000-5p cacCTGAACTttcagtctc
 2
 CAGUUCAG m7b (m6b->m7b) -0.018000 -0.063000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.97855675A>T COSN15434701 AOCS-150-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1275 gtcTCCCCCAtctgttaca
 2
 GUGGGGGA m7b (m7b->m6b) -0.321000 -0.163000 0.200000
hsa-miR-3154 gtctccCCCTTCTGttaca
 0 CAGAAGGG m8a Created no TS -0.054000 -0.600000
hsa-miR-3179 gtctcCCCCTTCTgttaca
 0 AGAAGGGG m8a Created no TS -0.094000 -0.250000
hsa-miR-4665-5p gtcTCCCCCAtctgttaca
 2
 CUGGGGGA m7b (m7b->m6b) -0.321000 -0.163000 0.120000
hsa-miR-4716-3p gtcTCCCCCTTctgttaca
 3
 AAGGGGGA m8a Created -0.238000 -0.397000 -0.910000
hsa-miR-4723-5p gtCTCCCCCAtctgttaca
 2
 UGGGGGAG m8a (m8a->m7a) -1.006000 -0.857000 0.070000
hsa-miR-5683 gtctccccCATCTGTtaca
 2
 UACAGAUG m7b Disrupted -0.001000 no TS 0.260000
hsa-miR-5698 gtCTCCCCCAtctgttaca
 2
 UGGGGGAG m8a (m8a->m7a) -0.995000 -0.846000 0.500000
hsa-miR-1275 gtcTCCCCCAtctgttaca
 2
 GUGGGGGA m7b (m7b->m6b) -0.321000 -0.163000 0.200000
hsa-miR-3154 gtctccCCCTTCTGttaca
 0 CAGAAGGG m8a Created no TS -0.054000 -0.600000
hsa-miR-3179 gtctcCCCCTTCTgttaca
 0 AGAAGGGG m8a Created no TS -0.094000 -0.250000
hsa-miR-4665-5p gtcTCCCCCAtctgttaca
 2
 CUGGGGGA m7b (m7b->m6b) -0.321000 -0.163000 0.120000
hsa-miR-4716-3p gtcTCCCCCTTctgttaca
 3
 AAGGGGGA m8a Created -0.238000 -0.397000 -0.910000
hsa-miR-4723-5p gtCTCCCCCAtctgttaca
 2
 UGGGGGAG m8a (m8a->m7a) -1.006000 -0.857000 0.070000
hsa-miR-5683 gtctccccCATCTGTtaca
 2
 UACAGAUG m7b Disrupted -0.001000 no TS 0.260000
hsa-miR-5698 gtCTCCCCCAtctgttaca
 2
 UGGGGGAG m8a (m8a->m7a) -0.995000 -0.846000 0.500000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
97855197 rs1443434 G G hsa-miR-181d-3p
21
 gcaCCCGGTGtac
 Disrupted
N
 -0.298
T hsa-miR-4672
hsa-miR-6768-5p
21
21
 gcaccCTGTGTAc
gcacCCTGTGTAc
 Created
Created
N
N
 -0.024
-0.228
97855667 rs41274260 T T hsa-miR-3175
hsa-miR-4499
hsa-miR-873-3p
4
6
6
 cttcagTCTCCCC
ctTCAGTCTcccc
cttCAGTCTCccc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.112
-0.063
-0.12
C hsa-miR-3929
hsa-miR-4419b
hsa-miR-4478
hsa-miR-485-5p
hsa-miR-6825-5p
hsa-miR-6884-5p
6
6
6
6
6
6
 ctTCAGCCTcccc
ctTCAGCCTcccc
ctTCAGCCTcccc
cttCAGCCTCccc
cttcagCCTCCCC
cttCAGCCTCccc
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.058
-0.068
-0.077
-0.114
-0.143
-0.151

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