SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001103184
Gene Symbol:	FMN1
Description:	Homo sapiens formin 1 (FMN1), mRNA.
Gene Location:	chr15(-):33057746-33360085
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32766762G>T			COSN6641306		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4300	aactgagtAGCTCCCttgg	0	UGGGAGCU	m7b	Disrupted	-0.083000	no TS	No effect
hsa-miR-4633-3p	aactgagTAGCTCCcttgg	0	AGGAGCUA	m7b	Disrupted	-0.063000	-0.056000	0.310000
hsa-miR-5591-5p	aactgagtAGCTCCCttgg	0	UGGGAGCU	m7b	Disrupted	-0.083000	no TS	0.770000
hsa-miR-920	aactgagtAGCTCCCttgg	0	GGGGAGCU	m7b	Disrupted	-0.083000	no TS	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32767116G>A			COSN1673446		RK067_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-626	tcgtatcgtAGACAGCTtt	0	AGCUGUCU	m8a	(m7a->m8a)	-0.034000	-0.079000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32767446T>C			COSN1673447		RK019_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-636	cctggaaaaCAAGCACtgg	1	UGUGCUUG	m7b	(m6b->m7b)	-0.035000	-0.037000	No effect
hsa-miR-636	cctggaaaaCAAGCACtgg	1	UGUGCUUG	m7b	(m6b->m7b)	-0.035000	-0.037000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32767591A>G			COSN6543943		ICGC_MB104		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4263	tttaaaaTTAGAAattgga	0	AUUCUAAG	m6b	Disrupted	0.063000	-0.028000	0.030000
hsa-miR-4735-5p	tttaAAATTAGaaattgga	0	CCUAAUUU	m7b	Disrupted	0.337000	0.201000	No effect
hsa-miR-4775	tttAAAATTAgaaattgga	0	UUAAUUUU	m7b	(m7b->m6c)	1.246000	1.142000	0.060000
hsa-miR-576-5p	tttaaaATTAGAAattgga	0	AUUCUAAU	m7b	Disrupted	-0.019000	-0.141000	-0.020000
hsa-miR-590-3p	ttTAAAATTAgaaattgga	0	UAAUUUUA	m8a	(m8a->m7b)	1.338000	1.223000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32767995G>T			COSN1673448		RK080_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3125	tttTTCCTCTcttcatgct	1	UAGAGGAA	m7b	(m6c->m7b)	0.009000	-0.043000	-0.090000
hsa-miR-3916	tttTTCCTCTcttcatgct	1	AAGAGGAA	m7b	(m6c->m7b)	0.026000	0.012000	No effect
hsa-miR-4709-3p	tttttcctCTCTTCAtgct	6	UUGAAGAG	m7b	Created	0.237000	0.263000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32767997T>C			COSN1673449		RK080_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4668-5p	cctTTTTCCCcgcttcatg	3	AGGGAAAA	m7b	(m6c->m7b)	-0.044000	0.037000	-0.030000
hsa-miR-4706	ccttttTCCCCGCTtcatg	0	AGCGGGGA	m8a	Created	no TS	-0.217000	-1.840000
hsa-miR-4749-5p	ccttttTCCCCGCttcatg	0	UGCGGGGA	m7b	Created	no TS	-0.217000	-2.590000
hsa-miR-4781-5p	cctttttCCCCGCTtcatg	0	UAGCGGGG	m7b	Created	no TS	-0.241000	-2.170000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32768120A>T			COSN7042944		8061178		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-let-7a-3p	ttataggagTTGTATAaaa	3	CUAUACAA	m7b	(m6b->m7b)	0.108000	0.187000	0.740000
hsa-let-7b-3p	ttataggagTTGTATAaaa	3	CUAUACAA	m7b	(m6b->m7b)	0.108000	0.187000	-0.940000
hsa-let-7f-1-3p	ttataggagTTGTATAaaa	3	CUAUACAA	m7b	(m6b->m7b)	0.105000	0.176000	0.010000
hsa-miR-300	ttataggagTTGTATAaaa	4	UAUACAAG	m7a	(m6a->m7a)	0.079000	0.184000	No effect
hsa-miR-381	ttataggagTTGTATAaaa	4	UAUACAAG	m7a	(m6a->m7a)	0.070000	0.171000	No effect
hsa-miR-4666a-3p	ttataggagTTGTATaaaa	0	CAUACAAU	m6b	Created	0.182000	0.286000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32771148C>T			COSN8172556		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1285-5p	gcagctagcTGAGATagca	1	GAUCUCAC	m6b	Created	0.025000	0.124000	-1.180000
hsa-miR-1307-3p	gcagctaGCCGAGatagca	1	ACUCGGCG	m6b	Disrupted	-0.167000	-0.108000	0.040000
hsa-miR-4638-5p	gcagctAGCCGAGatagca	1	ACUCGGCU	m7b	Disrupted	-0.450000	-0.338000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32772020G>C			COSN8741993		AOCS-091-3-0		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-142-3p	gtcACACTACtcgatgtat	1	UGUAGUGU	m7b	(m6c->m7b)	-0.063000	-0.037000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.32774277G>T			COSN8865226		SNUH_G16_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1306-5p	gcactGGAGGTGGaggacc	2	CCACCUCC	m8a	Disrupted	-0.322000	-0.104000	0.020000
hsa-miR-3925-3p	gcACTGGAGTtggaggacc	7	ACUCCAGU	m8a	(m7b->m8a)	-0.306000	-0.334000	0.180000
hsa-miR-508-5p	gcaCTGGAGTtggaggacc	0	UACUCCAG	m7b	(m6c->m7b)	no TS	-0.190000	-0.750000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
32766762	rs2204722	T	G	hsa-miR-4300 hsa-miR-4633-3p hsa-miR-5591-5p hsa-miR-6500-5p hsa-miR-6726-5p hsa-miR-920	0	tgagtAGCTCCCt tgagTAGCTCCct tgagtAGCTCCCt tgagTAGCTCCct tgagtAGCTCCCt tgagtAGCTCCCt	Created Created Created Created Created Created	N N N N N N	-0.083 -0.007 -0.083 -0.007 -0.083 -0.083
			T	hsa-miR-6760-5p	0	tgagtaTCTCCCT	Disrupted	N	-0.027
32768264	rs190392513	C	C	hsa-miR-3122 hsa-miR-3153 hsa-miR-3913-5p hsa-miR-450a-1-3p hsa-miR-4668-5p hsa-miR-579-3p hsa-miR-6513-5p hsa-miR-664b-3p hsa-miR-6733-5p hsa-miR-6739-5p hsa-miR-887-5p	1 1 1 1 1 3 1 3 1 1 1	cttTCCCAAAtga CTTTCCCAaatga cttTCCCAAAtga ctTTCCCAAAtga cTTTCCCAaatga ctttccCAAATGA cttTCCCAAAtga ctttccCAAATGA CTTTCCCAaatga CTTTCCCAaatga cttTCCCAAAtga	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N	0.03 0.022 0.027 0.078 0.054 0.056 0.036 0.056 0.022 0.001 0.044
			T	hsa-miR-4496 hsa-miR-4729 hsa-miR-5696 hsa-miR-651-5p	1 3 3 1	cTTTCCTAaatga ctttccTAAATGA ctttccTAAATGA cttTCCTAAAtga	Created Created Created Created	N N N N	0.079 0.174 0.124 0.058
32768494	rs186917684	A	A	hsa-miR-1279 hsa-miR-4775 hsa-miR-5007-3p	2 0 2	aaattAATATGAa AAATTAAtatgaa aaattaATATGAA	Disrupted Disrupted Disrupted	N N N	0.087 0.194 0.071
			G	hsa-miR-4735-5p hsa-miR-485-3p hsa-miR-539-3p	0	AAATTAGtatgaa aaattaGTATGAA aaattaGTATGAA	Created Created Created	N N N	0.09 0.03 0.02
32770667	rs184821986	-	T	hsa-miR-1253 hsa-miR-3929 hsa-miR-4251 hsa-miR-4419b hsa-miR-4478 hsa-miR-5197-3p hsa-miR-6770-5p	1 1 1 1 1 1 1	cTCTTCTCAgcct ctcttcTCAGCCT ctcTTCTCAGcct ctcttcTCAGCCT ctcttcTCAGCCT CTCTTCTcagcct ctCTTCTCAgcct	Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N	0.12 0.048 0.136 0.02 0.03 0.121 0.097
			A	hsa-miR-3611 hsa-miR-4709-3p hsa-miR-7974	1 1 1	ctCTTCACAgcct CTCTTCAcagcct ctcttCACAGCCt	Unknown Unknown Unknown	N N N	0.104 0.092 -0.025
32771074	rs114249190	A
			G	hsa-miR-3145-5p hsa-miR-508-5p	3 3	cccaTGGAGTAtc cccaTGGAGTAtc	Created Created	N N	0.029 0.041
32771487	rs77331764	C	C	hsa-miR-4696 hsa-miR-6847-3p	6 2	tTCTTGCAtgagc ttcttgCATGAGC	Disrupted Disrupted	N N	0.008 -0.042
			T	hsa-miR-300 hsa-miR-381-3p hsa-miR-485-3p hsa-miR-539-3p	7 7 6 6	ttCTTGTATgagc ttCTTGTATgagc ttctTGTATGAgc ttctTGTATGAgc	Created Created Created Created	N N N N	0.061 0.08 0.03 0.039
32771729	rs1057473	-	A	hsa-miR-1306-5p hsa-miR-3183 hsa-miR-4723-3p hsa-miR-5193 hsa-miR-6769b-3p hsa-miR-7111-3p	2 3 3 1 3 3	gagaGGAGGTGAt GAGAGGAggtgat GAGAGGAggtgat gaGAGGAGGtgat GAGAGGAggtgat GAGAGGAggtgat	Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N	-0.067 0.033 0.036 -0.001 0.04 0.083
			T	hsa-miR-197-3p hsa-miR-6800-3p	2 3	gagagGTGGTGAt GAGAGGTggtgat	Unknown Unknown	N N	0.005 0.059
32771944	rs114305949	A	A	hsa-miR-1322	1	tGCATCATgtatc	Disrupted	N	0.05
			T	hsa-miR-300 hsa-miR-381-3p	1 1	tgcatCTTGTATc tgcatCTTGTATc	Created Created	N N	0.125 0.135
32772434	rs62001260	G	G	hsa-miR-4666a-3p hsa-miR-5689	0	accATTGTATgct accatTGTATGCt	Disrupted Disrupted	N N	0.182 -0.032
32772435	rs28403314	C	T	hsa-miR-4666a-3p hsa-miR-5689	0	aaccATTGTATgc aaccatTGTATGC	Created Created	N N	0.182 -0.032
			C	hsa-miR-8069	0	AACCATCgtatgc	Disrupted	N	-0.032
32772509	rs183884319	C	C	hsa-miR-4709-3p	5	tagtttCTCTTCA	Disrupted	N	-0.038
			A	hsa-miR-4699-5p hsa-miR-577 hsa-miR-7844-5p	5 4 2	tagtttATCTTCA tagTTTATCTtca TAGTTTAtcttca	Created Created Created	N N N	0.024 0.1 0.111
32772590	rs1258731	C	C	hsa-miR-1307-3p hsa-miR-3119 hsa-miR-4638-5p	2 1 1	aaaaGCCGAGAag AAAAGCCgagaag aaaAGCCGAGAag	Disrupted Disrupted Disrupted	N N N	-0.108 0.059 -0.197
			T	hsa-miR-208a-5p hsa-miR-208b-5p hsa-miR-6787-3p	1 1 1	AAAAGCTgagaag AAAAGCTgagaag aaaAGCTGAGAag	Created Created Created	N N N	0.139 0.13 -0.039
32774277	rs16958712	A	G	hsa-miR-1306-5p	0	ctGGAGGTGgagg	Created	N	-0.218
			A	hsa-miR-3925-3p hsa-miR-766-3p	0	CTGGAGAtggagg CTGGAGAtggagg	Disrupted Disrupted	N N	-0.189 -0.118

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