SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_013231
Gene Symbol:	FLRT2
Description:	Homo sapiens fibronectin leucine rich transmembrane protein 2 (FLRT2), mRNA.
Gene Location:	chr14(+):85996487-86094270
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85623672A>G			COSN15328813		0094_CRUK_PC_0094_T1_DNA		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4662a-3p	aaaagtgCTATCTTTtcta	22	AAAGAUAG	m8a	Disrupted	-0.171000	no TS	0.240000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85623739A>C			COSN15591359		C0035T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85623872C>A			COSN8589042		2296_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-200a-5p	cctggtgGTAAGATGaaag	10	CAUCUUAC	m8a	Created	-0.188000	-0.263000	-0.480000
hsa-miR-200b-5p	cctggtgGTAAGATGaaag	10	CAUCUUAC	m8a	Created	-0.188000	-0.263000	-0.260000
hsa-miR-4256	cctggtGGTCAGATgaaag	0	AUCUGACC	m8a	Disrupted	-0.319000	-0.110000	0.060000
hsa-miR-452-3p	cctggtggtCAGATGAaag	0	CUCAUCUG	m7b	(m7b->m6c)	-0.210000	-0.039000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85623976C>T			COSN8589043		951_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3180-5p	ctccaggTCTGGAAGacag	0	CUUCCAGA	m8a	Created	no TS	-0.039000	No effect
hsa-miR-3687	ctccagGTCCGGaagacag	0	CCCGGACA	m6b	Disrupted	-0.247000	no TS	No effect
hsa-miR-4442	ctccagGTCCGGaagacag	0	GCCGGACA	m6b	Disrupted	-0.264000	no TS	1.070000
hsa-miR-4664-3p	ctccaggtCCGGAAGacag	0	CUUCCGGU	m7a	Disrupted	NA	NA	No effect
hsa-miR-492	ctcCAGGTCCggaagacag	1	AGGACCUG	m7b	(m7b->m6b)	-0.214000	-0.046000	No effect
hsa-miR-520a-5p	ctccaggTCTGGAagacag	0	CUCCAGAG	m6b	Created	no TS	-0.078000	No effect
hsa-miR-525-5p	ctccaggTCTGGAagacag	0	CUCCAGAG	m6b	Created	no TS	-0.068000	No effect
hsa-miR-631	ctCCAGGTCTggaagacag	2	AGACCUGG	m8a	(m7a->m8a)	-0.168000	-0.196000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85624048G>A			COSN8589044		J83_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-16-1-3p	gtgggaAATACTGaaagca	0	CCAGUAUU	m7b	Created	no TS	-0.047000	-1.620000
hsa-miR-222-5p	gtgggaaaTACTGAaagca	0	CUCAGUAG	m6b	Created	no TS	-0.022000	-0.030000
hsa-miR-30a-3p	gtgggaaatACTGAAAGca	7	CUUUCAGU	m8a	(m7b->m8a)	-0.083000	-0.076000	-0.020000
hsa-miR-30d-3p	gtgggaaatACTGAAAGca	7	CUUUCAGU	m8a	(m7b->m8a)	-0.083000	-0.067000	-0.120000
hsa-miR-30e-3p	gtgggaaatACTGAAAGca	7	CUUUCAGU	m8a	(m7b->m8a)	-0.083000	-0.085000	-0.110000
hsa-miR-4291	gtgggaaaTGCTGAAagca	1	UUCAGCAG	m7a	Disrupted	-0.120000	-0.070000	0.010000
hsa-miR-4310	gtgggaAATGCTGaaagca	0	GCAGCAUU	m7b	Disrupted	-0.280000	-0.124000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85624056C>T			9_51836		CRC-5-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3160-5p	tgctGAAAGCaccaggagg	17	GGCUUUCU	m6b	Disrupted	0.064	0.061	-0.23
hsa-miR-3907	tgctgaaAGCACCaggagg	6	AGGUGCUC	m6b	Disrupted	-0.099	no TS	2.29
hsa-miR-548q	tgctgaaaGCACCAGgagg	6	GCUGGUGC	m7b	Disrupted	-0.318	-0.148	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85624312A>G			COSN8387841		tumor_4135099		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85624589T>C			COSN5392225		RK164_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1305	agtatcatGTTGAAAtagc	2	UUUUCAAC	m7b	Disrupted	0.358000	0.350000	No effect
hsa-miR-205-3p	agtatcatgCTGAAATagc	12	GAUUUCAG	m7b	(m6c->m7b)	0.112000	0.094000	-0.020000
hsa-miR-421	agtatcaTGTTGAaatagc	7	AUCAACAG	m6b	Disrupted	-0.176000	-0.184000	0.010000
hsa-miR-4291	agtatcaTGCTGAAatagc	1	UUCAGCAG	m7a	Created	-0.120000	-0.156000	No effect
hsa-miR-4310	agtatcATGCTGaaatagc	0	GCAGCAUU	m6b	Created	-0.280000	-0.316000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85624767T>C			COSN7031388		8069459		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-568	acgtacTTATACATtttaa	4	AUGUAUAA	m8a	Disrupted	0.041000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85624865G>T			9_122481		CRC-9-Tumor		Colorectal adenocarcinoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4678	gcAATACCTTgtttccacc	4	AAGGUAUU	m8a	(m7a->m8a)	0.094	0.067	No effect
hsa-miR-624-3p	gcaatACCTTGTttccacc	5	CACAAGGU	m7b	Created	-0.27	-0.33	-0.11

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85624960G>A			COSN5210585		SS6003117		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-129-1-3p	gcaattgtgAAGGGCTaat	17	AAGCCCUU	m7b	(m6c->m7b)	-0.138000	-0.171000	-0.160000
hsa-miR-129-2-3p	gcaattgtgAAGGGCTaat	17	AAGCCCUU	m7b	(m6c->m7b)	-0.138000	-0.171000	-0.080000
hsa-miR-4290	gcaattgtGGAGGGCtaat	1	UGCCCUCC	m7b	Disrupted	-0.160000	no TS	0.010000
hsa-miR-4687-5p	gcaattgtgGAGGGCTaat	17	CAGCCCUC	m7b	(m7b->m6c)	-0.207000	-0.111000	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85625079T>A			COSN14954845		LP6005409-DNA_E01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4503	cgTGCTTAAAtctagatac	2	UUUAAGCA	m8a	(m7a->m8a)	0.247000	0.292000	-0.030000
hsa-miR-4777-5p	cgtgcttaaATCTAGAtac	16	UUCUAGAU	m7b	(m6c->m7b)	-0.054000	-0.042000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85625465G>T			COSN5210586		SS6003137		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-491-3p	gaataaGCATAAaatataa	0	CUUAUGCA	m6b	Created	no TS	0.024000	-0.010000
hsa-miR-544a	gaataaGCAGAAaatataa	4	AUUCUGCA	m6b	Disrupted	-0.021000	-0.038000	0.980000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85625573G>C			COSN1664278		RK052_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3978	gtgactctgCTTTCCAttt	0	GUGGAAAG	m7b	(m6c->m7b)	no TS	0.040000	No effect
hsa-miR-4261	gtgactctgGTTTCCattt	10	AGGAAACA	m6b	Disrupted	0.080000	0.053000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85625836A>C			COSN4759917		tumor_4135350		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][Burkitt_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2113	tattCACAAAatactcatt	12	AUUUGUGC	m6b	Disrupted	-0.033000	-0.104000	0.040000
hsa-miR-4781-3p	tattcaCAACATactcatt	0	AAUGUUGG	m6b	Created	no TS	0.070000	-6.580000
hsa-miR-496	tattcacaaAATACTCAtt	1	UGAGUAUU	m8a	(m8a->m7b)	-0.214000	-0.208000	0.010000
hsa-miR-567	tattcacAACATACTcatt	0	AGUAUGUU	m8a	Created	no TS	0.030000	-2.050000
hsa-miR-758	tatTCACAAAatactcatt	1	UUUGUGAC	m7a	(m7a->m6a)	-0.003000	-0.024000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85626347G>T			COSN15397612		0008_CRUK_PC_0008_T1_DNA		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4522	attagtcaAGAGTCAaggt	4	UGACUCUG	m7a	Disrupted	0.029000	no TS	No effect
hsa-miR-4522	attagtcaAGAGTCAaggt	4	UGACUCUG	m7a	Disrupted	0.029000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85626546A>G			COSN15050747		LP6005409-DNA_H01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-549	ttgacAGTTGTCtatagcc	0	UGACAACU	m7b	Created	no TS	-0.015000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85626812C>A			COSN8589045		J76_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85627715T>G			COSN15160396		LP6005690-DNA_F02		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-409-5p	cactgaaaGGTAACCTgat	0	AGGUUACC	m8a	Created	no TS	-0.286000	-9.650000
hsa-miR-4724-3p	cactgaAAGGTAacctgat	0	GUACCUUC	m6b	Created	no TS	-0.082000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85627860A>C			COSN14900586		LP6007504-DNA_A01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-323b-5p	taatGACAACCTtcactct	2	AGGUUGUC	m8a	Created	0.003000	-0.292000	-1.280000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.85627888T>C			COSN6262752		RK028_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3074-3p	agtaccttgCTGATATatt	18	GAUAUCAG	m7b	(m6c->m7b)	0.025000	-0.195000	0.230000
hsa-miR-421	agtacctTGTTGATatatt	7	AUCAACAG	m7a	Disrupted	-0.176000	-0.176000	0.020000
hsa-miR-624-3p	agtACCTTGTtgatatatt	17	CACAAGGU	m7b	(m7b->m6b)	-0.270000	0.013000	4.130000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
85623744	rs148332320	T	T	hsa-miR-545-3p hsa-miR-891b	18 0	aaaaagTTGCTGA aaaAAGTTGCtga	Disrupted Disrupted	N N	-0.123 -0.217
			C	hsa-miR-208a-5p hsa-miR-208b-5p hsa-miR-214-3p hsa-miR-3619-5p hsa-miR-4291 hsa-miR-646 hsa-miR-761 hsa-miR-922	0	aAAAAGCTgctga aAAAAGCTgctga aaaaagCTGCTGA aaaaagCTGCTGA aaaaagCTGCTGA aaaaAGCTGCTga aaaaagCTGCTGA aaaaagCTGCTGA	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.13 -0.139 -0.137 -0.141 -0.19 -0.237 -0.137 -0.15
85624472	rs183028461	G	G	hsa-miR-3622a-3p hsa-miR-3622b-3p hsa-miR-6765-3p	2 2 2	caaCAGGTGAtca caaCAGGTGAtca caaCAGGTGAtca	Disrupted Disrupted Disrupted	N N N	-0.075 -0.068 -0.062
			A	hsa-miR-1267 hsa-miR-367-5p hsa-miR-452-3p	3 3 2	CAACAGAtgatca CAACAGAtgatca caaCAGATGAtca	Created Created Created	N N N	-0.045 -0.045 -0.083
85624878	rs45549637	G	G	hsa-miR-1910-5p hsa-miR-455-3p	3 2	accttGGACTGAc acctTGGACTGAc	Disrupted Disrupted	N N	-0.021 -0.055
			T	hsa-miR-624-3p	4	ACCTTGTActgac	Created	N	-0.003
85625167	rs45472199	A
			A	hsa-miR-297 hsa-miR-567	1 1	ACATACAttatca ACATACAttatca	Disrupted Disrupted	N N	0.028 0.032
85625832	rs12890799	A	A	hsa-miR-1257 hsa-miR-2113 hsa-miR-3611 hsa-miR-5010-3p hsa-miR-758-3p	3 9 2 9 1	ttATTCACAaaat ttattCACAAAAt ttaTTCACAAaat ttattCACAAAAt ttatTCACAAAat	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	0.044 0.071 0.007 0.064 0.021
			T	hsa-miR-580-3p hsa-miR-8055	2 9	ttATTCTCAAaat ttattCTCAAAAt	Created Created	N N	0.013 0.057
85625838	rs12892167	T	T	hsa-miR-496	1	acaaAATACTCAt	Disrupted	N	0.006
			G	hsa-miR-627-5p hsa-miR-924	1 1	acaaaAGACTCAt acaaAAGACTCAt	Created Created	N N	-0.105 -0.065
85626773	rs183512692	C	C	hsa-miR-95-3p	2	gatgttCGTTGAA	Disrupted	N	-0.119
			T	hsa-miR-3065-5p hsa-miR-421 hsa-miR-495-3p hsa-miR-5688 hsa-miR-7159-5p	2 2 2 2 2	gatgTTTGTTGAa gatgttTGTTGAA gatGTTTGTTgaa gatGTTTGTTgaa gatgtTTGTTGAA	Created Created Created Created Created	N N N N N	0.043 -0.005 0.022 -0.006 -0.032
85627034	rs1129671	C	C	hsa-miR-1203 hsa-miR-4683	0	gatCTCCGGAcct GATCTCCggacct	Disrupted Disrupted	N N	-0.14 -0.08
			T	hsa-miR-198 hsa-miR-4756-3p hsa-miR-520a-5p hsa-miR-525-5p	0	gatcTCTGGACct gATCTCTGgacct gatCTCTGGAcct gatCTCTGGAcct	Created Created Created Created	N N N N	-0.055 0.037 -0.078 -0.05
85627578	rs36121292	-	-	hsa-let-7c-3p hsa-miR-3177-5p hsa-miR-6867-5p	1 1 4	tgcTTGTACAcacac tgctTGTACACAcac tgcttgtACACACAc	Unknown Unknown Unknown	N N N	-0.029 -0.319 -0.069
			AC	hsa-miR-1273g-5p hsa-miR-409-5p	4 1	tgcttgtAACCACAcac tgcttGTAACCAcacac	Unknown Unknown	N N	-0.094 -0.12
85627625	rs117134578	C	C	hsa-miR-211-3p hsa-miR-4685-5p hsa-miR-6837-5p hsa-miR-7113-5p hsa-miR-7845-5p	2 2 2 2 2	ggtGTCCCTGgaa ggtgtCCCTGGAa ggtgtCCCTGGAa ggtgTCCCTGGAa ggTGTCCCTggaa	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.226 -0.161 -0.168 -0.362 -0.15
			T	hsa-miR-3180-5p hsa-miR-520a-5p hsa-miR-525-5p	2 2 2	ggtgtcTCTGGAA ggtgtCTCTGGAA ggtgtCTCTGGAA	Created Created Created	N N N	-0.121 -0.368 -0.347

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