SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000142
Gene Symbol:	FGFR3
Description:	Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mRNA.
Gene Location:	chr4(+):1795038-1810599
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807398T>C			COSN7756798		8035388		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3939	gtgtgtgTGCGCGTgtgtg	0	UACGCGCA	m7b	Created	no TS	-0.348000	0.810000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807399GC>-			cosmic_v64_1860011		NA		[upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807401GT>-			cosmic_v64_1860011		NA		[upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807404T>C			cosmic_v64_1860011				Esophageal
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807412T>G			COSN8490446		J32_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-329	gtgtgtgtgGGTGTGTgca	0	AACACACC	m7b	(m6c->m7b)	no TS	-0.100000	0.470000
hsa-miR-362-3p	gtgtgtgtgGGTGTGTgca	0	AACACACC	m7b	(m6c->m7b)	no TS	-0.100000	0.830000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807635G>A			cosmic_v64_1760524				Leukemia/T-ALL
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-19a-3p	tctgccTTTGCACcacggg	1	UGUGCAAA	m7b	Disrupted	0.023	no TS	No effect
hsa-miR-19b-3p	tctgccTTTGCACcacggg	1	UGUGCAAA	m7b	Disrupted	0.023	no TS	No effect
hsa-miR-518a-5p	tctgcCTTTGCAccacggg	2	CUGCAAAG	m7b	Disrupted	0.028	no TS	No effect
hsa-miR-527	tctgcCTTTGCAccacggg	2	CUGCAAAG	m7b	Disrupted	0.028	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807921T>C			cosmic_v64_1760547				Leukemia/T-ALL
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-297	tataACATACATggaagag	0	AUGUAUGU	m8a	Created	-0.077	-0.203	1.85
hsa-miR-4716-5p	tataacatACATGGAagag	0	UCCAUGUU	m7a	Created	no TS	-0.071	-0.97
hsa-miR-567	tatAACATACatggaagag	0	AGUAUGUU	m7b	(m6b->m7b)	no TS	-0.139	-1.61
hsa-miR-587	tataacataTATGGAAgag	0	UUUCCAUA	m7b	(m7b->m6c)	-0.086	no TS	1.77

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.1807995G>A			COSN5012423		SS6003323		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3173-5p	gccctggGCAGGGCgtggg	0	UGCCCUGC	m7b	Created	-0.185000	-0.212000	-0.050000
hsa-miR-3173-5p	gccctggGCAGGGCgtggg	0	UGCCCUGC	m7b	Created	-0.185000	-0.212000	-0.050000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

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