SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_032738
Gene Symbol:	FCRLA
Description:	Homo sapiens Fc receptor-like A (FCRLA), transcript variant 1, mRNA.
Gene Location:	chr1(+):161676761-161684142
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161713553T>A			COSN1091069		HCC122T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-216b	gaattAGAGATTagctata	0	AAAUCUCU	m7b	Created	no TS	-0.309000	-4.760000
hsa-miR-3675-3p	gaatTAGAGATtagctata	0	CAUCUCUA	m7b	Created	no TS	-0.232000	-0.520000
hsa-miR-618	gaatTAGAGTTTagctata	1	AAACUCUA	m8a	Disrupted	-0.226000	no TS	5.430000
hsa-miR-216b	gaattAGAGATTagctata	0	AAAUCUCU	m7b	Created	no TS	-0.309000	-4.760000
hsa-miR-3675-3p	gaatTAGAGATtagctata	0	CAUCUCUA	m7b	Created	no TS	-0.232000	-0.520000
hsa-miR-618	gaatTAGAGTTTagctata	1	AAACUCUA	m8a	Disrupted	-0.226000	no TS	5.430000
hsa-miR-216b	gaattAGAGATTagctata	0	AAAUCUCU	m7b	Created	no TS	-0.309	-4.76
hsa-miR-3675-3p	gaatTAGAGATtagctata	0	CAUCUCUA	m7b	Created	no TS	-0.232	-0.52
hsa-miR-618	gaatTAGAGTTTagctata	1	AAACUCUA	m8a	Disrupted	-0.226	no TS	5.43

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161713827C>A			COSN1409444		RK159_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1265	gccgctaaACATCCTataa	3	CAGGAUGU	m7b	Disrupted	-0.271000	no TS	-4.720000
hsa-miR-1290	gccgctaAAAATCCtataa	0	UGGAUUUU	m7b	Created	no TS	-0.066000	No effect
hsa-miR-3167	gccgctaaAAATCCTataa	3	AGGAUUUC	m7a	Created	-0.196000	-0.196000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161714018G>A			COSN6005389		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1226-3p	cagtctttaGCTGGTGcta	1	UCACCAGC	m7b	(m7b->m6c)	-0.245000	no TS	No effect
hsa-miR-4744	cagTCTTTAGctggtgcta	2	UCUAAAGA	m7b	(m7b->m6b)	-0.143000	-0.127000	-1.470000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161714173T>C			COSN8321116		PCSI_0084_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3121-3p	ttagtgcccCTATTTAaaa	0	UAAAUAGA	m7a	(m6b->m7a)	no TS	0.025000	No effect
hsa-miR-4688	ttagTGCCCCTAtttaaaa	0	UAGGGGCA	m8a	Created	no TS	-0.455000	-1.570000
hsa-miR-5692a	ttagtgcccTTATTTaaaa	2	CAAAUAAU	m6b	Disrupted	0.104000	no TS	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
161713548	rs1138859	T	T	hsa-miR-4735-5p hsa-miR-5571-5p hsa-miR-618	0	gagAATTAGAgtt GAGAATTAgagtt gagaatTAGAGTT	Disrupted Disrupted Disrupted	N N N	-0.024 -0.203 -0.226
161714179	rs1104911	A	A	hsa-miR-5692a	2	TTATTTAaaaagg	Disrupted	N	0.104
			G	hsa-miR-1305 hsa-miR-3671 hsa-miR-607	2 2 2	ttatTTGAAAAgg tTATTTGAAaagg ttATTTGAAAagg	Created Created Created	N N N	0.047 -0.102 -0.046

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