SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_000138 |
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Gene Symbol: | FBN1 |
Description: | Homo sapiens fibrillin 1 (FBN1), mRNA. |
Gene Location: | chr15(-):48700502-48937985 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.48408410G>C | COSN6274619 | RK181_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1262 |
gtttacTCACCCAaaatca |
0 | AUGGGUGA | m7b | Created | no TS | -0.445000 |
-0.060000 |
|
hsa-miR-4701-3p |
gtttacTCACCCAaaatca |
0 | AUGGGUGA | m7b | Created | no TS | -0.445000 |
-0.190000 |
|
hsa-miR-4710 |
gtttaCTCACCCaaaatca |
0 | GGGUGAGG | m7a | Created | NA | NA | No effect | |
hsa-miR-647 |
gtttactCAGCCAaaatca |
12 |
GUGGCUGC | m6b | Disrupted | -0.194000 | no TS |
0.240000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.48408558G>C | COSN9625747 | C0001T | [kidney][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-100-3p |
cagAAGCTTGaaaatatct |
0 | CAAGCUUG | m7a | (m7a->m6b) | NA | NA | No effect | |
hsa-miR-127-5p |
cagaAGCTTCAaaatatct |
0 | CUGAAGCU | m7b | Created | no TS | -0.338000 |
-0.220000 |
|
hsa-miR-498 |
cagaaGCTTGAAAatatct |
14 |
UUUCAAGC | m8a | Disrupted | -0.309000 | -0.030000 |
0.060000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.48409506C>T | COSN8174173 | PCSI_0083_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr15:g.48409589A>C | COSN15014485 | SM-4B296 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-548at-5p |
attgctgTAACTTTTggtt |
2 |
AAAAGUUA | m8a | Disrupted | 0.131000 | no TS |
1.300000 |
|
hsa-miR-548m |
attgctgTACCTTTtggtt |
8 |
CAAAGGUA | m7b | Created | -0.115000 | -0.063000 |
-0.030000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr15:g.48410111A>T | COSN8745698 | AOCS-093-3-6 | [ovary][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4729 |
aatgtcATAAATGtcacaa |
15 |
UCAUUUAU | m7b | Disrupted | 0.053000 | -0.023000 | No effect |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
48410211 | rs113200355 | C | C |
hsa-miR-2467-5p hsa-miR-3188 hsa-miR-3975 hsa-miR-4649-3p hsa-miR-4687-3p hsa-miR-485-5p hsa-miR-6884-5p |
8 8 8 9 5 7 7 |
aacAGCCTCAgtg aacAGCCTCAgtg aacAGCCTCAgtg aacaGCCTCAGtg AACAGCCtcagtg aaCAGCCTCAgtg aaCAGCCTCAgtg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.066 -0.068 -0.073 -0.097 -0.066 -0.188 -0.209 |
T |
hsa-miR-127-5p hsa-miR-3928-5p hsa-miR-6806-3p |
8 8 8 |
aacAGCTTCAgtg aacAGCTTCAgtg aacAGCTTCAgtg |
Created Created Created |
N N N |
-0.01 -0.027 -0.034 |