SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000138
Gene Symbol: FBN1
Description: Homo sapiens fibrillin 1 (FBN1), mRNA.
Gene Location: chr15(-):48700502-48937985
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr15:g.48408410G>C COSN6274619 RK181_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1262 gtttacTCACCCAaaatca
0 AUGGGUGA m7b Created no TS -0.445000 -0.060000
hsa-miR-4701-3p gtttacTCACCCAaaatca
0 AUGGGUGA m7b Created no TS -0.445000 -0.190000
hsa-miR-4710 gtttaCTCACCCaaaatca
0 GGGUGAGG m7a Created NA NA No effect
hsa-miR-647 gtttactCAGCCAaaatca
12
GUGGCUGC m6b Disrupted -0.194000 no TS 0.240000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.48408558G>C COSN9625747 C0001T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-100-3p cagAAGCTTGaaaatatct
0 CAAGCUUG m7a (m7a->m6b) NA NA No effect
hsa-miR-127-5p cagaAGCTTCAaaatatct
0 CUGAAGCU m7b Created no TS -0.338000 -0.220000
hsa-miR-498 cagaaGCTTGAAAatatct
14
UUUCAAGC m8a Disrupted -0.309000 -0.030000 0.060000


Mutation Mutation ID Sample Name Cancer Type
chr15:g.48409506C>T COSN8174173 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr15:g.48409589A>C COSN15014485 SM-4B296 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548at-5p attgctgTAACTTTTggtt
2
AAAAGUUA m8a Disrupted 0.131000 no TS 1.300000
hsa-miR-548m attgctgTACCTTTtggtt
8
CAAAGGUA m7b Created -0.115000 -0.063000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.48410111A>T COSN8745698 AOCS-093-3-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4729 aatgtcATAAATGtcacaa
15
UCAUUUAU m7b Disrupted 0.053000 -0.023000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
48410211 rs113200355 C C hsa-miR-2467-5p
hsa-miR-3188
hsa-miR-3975
hsa-miR-4649-3p
hsa-miR-4687-3p
hsa-miR-485-5p
hsa-miR-6884-5p
8
8
8
9
5
7
7
aacAGCCTCAgtg
aacAGCCTCAgtg
aacAGCCTCAgtg
aacaGCCTCAGtg
AACAGCCtcagtg
aaCAGCCTCAgtg
aaCAGCCTCAgtg
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
-0.066
-0.068
-0.073
-0.097
-0.066
-0.188
-0.209
T hsa-miR-127-5p
hsa-miR-3928-5p
hsa-miR-6806-3p
8
8
8
aacAGCTTCAgtg
aacAGCTTCAgtg
aacAGCTTCAgtg
Created
Created
Created
N
N
N
-0.01
-0.027
-0.034

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