SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_174911
Gene Symbol:	FAM84B
Description:	Homo sapiens family with sequence similarity 84, member B (FAM84B), mRNA.
Gene Location:	chr8(-):127564682-127570711
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.126553600A>G			COSN6911473		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-141-3p	gaagacggCAGTGTTgtgg	12	UAACACUG	m7b	Disrupted	0.070000	no TS	0.010000
hsa-miR-200a-3p	gaagacggCAGTGTTgtgg	12	UAACACUG	m7b	Disrupted	0.070000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.126553984T>C			COSN9255117		C0052T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4520a-3p	gaatggcaCTGTCCAgctc	2	UUGGACAG	m7b	Disrupted	0.041000	no TS	No effect
hsa-miR-4638-3p	gaatggcacTGTCCAGctc	2	CCUGGACA	m7b	(m7b->m6b)	0.060000	no TS	0.030000
hsa-miR-4804-5p	gaatggcaCCGTCCAgctc	0	UUGGACGG	m7b	Created	no TS	-0.070000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.126554012C>T			COSN2259979		RK066_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3618	ccgTGTAGACAagtgggag	2	UGUCUACA	m8a	Disrupted	0.065000	no TS	1.170000
hsa-miR-934	ccgtGTAGACAagtgggag	2	UGUCUACU	m7a	Disrupted	0.033000	no TS	7.180000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.126555189C>G			COSN14705929		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4428	aagcagTCTCCTTGttgct	6	CAAGGAGA	m8a	Disrupted	-0.155000	-0.208000	No effect
hsa-miR-4494	aagCAGTCTGcttgttgct	0	CCAGACUG	m7b	(m6c->m7b)	no TS	-0.007000	-0.400000
hsa-miR-4771	aagcAGTCTGCTtgttgct	0	AGCAGACU	m8a	Created	no TS	-0.072000	-6.600000
hsa-miR-873-3p	aagCAGTCTCCttgttgct	5	GGAGACUG	m8a	Disrupted	-0.019000	no TS	2.350000

Mutation			Mutation ID		Sample Name		Cancer Type
chr8:g.126556398C>A			COSN8315114		TCGA-AO-A128-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3609	ccgctgcTCACTTTctccc	0	CAAAGUGA	m7b	Created	0.186000	0.194000	No effect
hsa-miR-548ah-5p	ccgctgcTCACTTTctccc	0	AAAAGUGA	m7b	Created	0.167000	0.147000	-0.020000
hsa-miR-5681a	ccgctgctCCCTTTCTccc	2	AGAAAGGG	m8a	Disrupted	-0.124000	no TS	0.990000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
126553545	rs190419066	T	T	hsa-miR-106a-5p hsa-miR-106b-5p hsa-miR-17-5p hsa-miR-20a-5p hsa-miR-20b-5p hsa-miR-3609 hsa-miR-4263 hsa-miR-4509 hsa-miR-4744 hsa-miR-4796-3p hsa-miR-4799-5p hsa-miR-519d-3p hsa-miR-526b-3p hsa-miR-548ah-5p hsa-miR-576-5p hsa-miR-93-5p	14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14	aCACTTTAgaaaa aCACTTTAgaaaa aCACTTTAgaaaa aCACTTTAgaaaa aCACTTTAgaaaa aCACTTTAgaaaa acactTTAGAAAa acaCTTTAGAaaa acaCTTTAGAaaa aCACTTTAgaaaa acacTTTAGAAaa aCACTTTAgaaaa aCACTTTAgaaaa aCACTTTAgaaaa acactTTAGAAAa aCACTTTAgaaaa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N	0.051 0.051 0.051 0.051 0.051 0.044 0.073 0.022 0.035 0.033 0.051 0.051 0.051 0.044 0.071 0.051
			C	hsa-miR-3616-5p hsa-miR-4762-3p hsa-miR-4795-5p hsa-miR-573	14 14 14 14	aCACTTCAgaaaa acactTCAGAAAa aCACTTCAgaaaa aCACTTCAgaaaa	Created Created Created Created	N N N N	-0.098 0.019 -0.016 -0.107
126553549	rs139933896	A	A	hsa-miR-106a-5p hsa-miR-106b-5p hsa-miR-17-5p hsa-miR-20a-5p hsa-miR-20b-5p hsa-miR-3609 hsa-miR-4796-3p hsa-miR-519d-3p hsa-miR-526b-3p hsa-miR-548ah-5p hsa-miR-93-5p	14 14 14 14 14 14 14 14 14 14 14	tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg tttgaCACTTTAg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N	0.051 0.051 0.051 0.051 0.051 0.044 0.033 0.051 0.051 0.044 0.051
			G	hsa-miR-518a-3p hsa-miR-518b hsa-miR-518c-3p hsa-miR-518d-3p hsa-miR-518f-3p	14 14 14 14 14	tttgaCGCTTTAg tttgaCGCTTTAg tttgaCGCTTTAg tttgaCGCTTTAg tttgaCGCTTTAg	Created Created Created Created Created	N N N N N	-0.086 -0.093 -0.093 -0.086 -0.093

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