SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001082967
Gene Symbol: FAM19A5
Description: Homo sapiens family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 (FAM19A5), transcript variant 1, mRNA.
Gene Location: chr22(+):48885287-49147744
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr22:g.48750089C>T COSN14882044 LP6005500-DNA_B03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1279 tcagCAATATGcagtctgt
 0 UCAUAUUG m7b Created no TS 0.045000 -0.540000
hsa-miR-217 tcagcaatATGCAGTctgt
 0 UACUGCAU m7b Created no TS -0.128000 -4.490000
hsa-miR-448 tcagcaATATGCAgtctgt
 0 UUGCAUAU m7b Created no TS -0.074000 -4.200000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.48750112C>T COSN8160949 ASHPC_0015_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1285-3p gcccggccgTGCCCAGccc
 0 UCUGGGCA m7b (m6c->m7b) no TS 0.004000 No effect
hsa-miR-3177-3p gcccgGCCGTGCccagccc
 0 UGCACGGC m7b Created no TS -0.169000 -0.040000
hsa-miR-3178 gcccggcCGCGCCCagccc
 0 GGGGCGCG m7b Disrupted -0.439000 no TS 3.420000
hsa-miR-3187-5p gcccggccgTGCCCAGccc
 0 CCUGGGCA m7b (m6c->m7b) no TS -0.033000 No effect
hsa-miR-4479 gcccgGCCGCGCccagccc
 1
 CGCGCGGC m7b Disrupted -0.469000 -0.210000 1.880000
hsa-miR-4486 gcccggccgCGCCCAGCcc
 1
 GCUGGGCG m8a (m8a->m7b) -0.073000 no TS 3.370000
hsa-miR-5189 gcccggccgTGCCCAGccc
 0 UCUGGGCA m7b (m6c->m7b) no TS -0.033000 -0.120000
hsa-miR-564 gcccggCCGTGCCcagccc
 1
 AGGCACGG m7b Created -0.183000 -0.322000 No effect
hsa-miR-612 gcccggccgTGCCCAGCcc
 0 GCUGGGCA m8a (m7b->m8a) no TS -0.014000 -0.360000
hsa-miR-1285-3p gcccggccgTGCCCAGccc
 0 UCUGGGCA m7b (m6c->m7b) no TS 0.004000 No effect
hsa-miR-3177-3p gcccgGCCGTGCccagccc
 0 UGCACGGC m7b Created no TS -0.169000 -0.040000
hsa-miR-3178 gcccggcCGCGCCCagccc
 0 GGGGCGCG m7b Disrupted -0.439000 no TS 3.420000
hsa-miR-3187-5p gcccggccgTGCCCAGccc
 0 CCUGGGCA m7b (m6c->m7b) no TS -0.033000 No effect
hsa-miR-4479 gcccgGCCGCGCccagccc
 1
 CGCGCGGC m7b Disrupted -0.469000 -0.210000 1.880000
hsa-miR-4486 gcccggccgCGCCCAGCcc
 1
 GCUGGGCG m8a (m8a->m7b) -0.073000 no TS 3.370000
hsa-miR-5189 gcccggccgTGCCCAGccc
 0 UCUGGGCA m7b (m6c->m7b) no TS -0.033000 -0.120000
hsa-miR-564 gcccggCCGTGCCcagccc
 1
 AGGCACGG m7b Created -0.183000 -0.322000 No effect
hsa-miR-612 gcccggccgTGCCCAGCcc
 0 GCUGGGCA m8a (m7b->m8a) no TS -0.014000 -0.360000


Mutation Mutation ID Sample Name Cancer Type
chr22:g.48750136G>A COSN8021401 8069329 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr22:g.48750355G>A COSN8021402 8047815 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3650 aacctggACACACCctcac
 0 AGGUGUGU m7b Created no TS -0.076000 -0.020000
hsa-miR-4455 aacctggaCACACCCTcac
 0 AGGGUGUG m8a Created no TS -0.172000 -0.050000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.48750565G>A COSN8021403 8067226 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4288 cacGCAGACAccgggaacg
 0 UUGUCUGC m7b (m6b->m7b) no TS 0.027000 -0.120000
hsa-miR-4783-3p cacgcagaCACCGGGaacg
 0 CCCCGGUG m7b Created no TS -0.407000 -1.430000
hsa-miR-632 cacGCAGACACcgggaacg
 0 GUGUCUGC m8a Created no TS 0.008000 -1.340000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.48750573C>T COSN8021404 8047810 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20a-3p cgccgggAATGCAGgccgc
 0 ACUGCAUU m7b Created no TS 0.087000 -0.130000
hsa-miR-3193 cgccgggaACGCAGGccgc
 0 UCCUGCGU m7b Disrupted -0.153000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.48750580C>T COSN8612871 745_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1234 aacgCAGGCCGctttattc
 1
 UCGGCCUG m7b Disrupted -0.171000 no TS 0.990000
hsa-miR-4422 aacgcaggcTGCTTTattc
 0 AAAAGCAU m6b Created no TS 0.048000 -3.000000
hsa-miR-518a-3p aacgcaggcCGCTTTattc
 0 GAAAGCGC m6b Disrupted -0.080000 no TS 8.190000
hsa-miR-518b aacgcaggcCGCTTTattc
 0 CAAAGCGC m6b Disrupted -0.080000 no TS 7.450000
hsa-miR-518c-3p aacgcaggcCGCTTTattc
 0 CAAAGCGC m6b Disrupted -0.080000 no TS 4.610000
hsa-miR-518d-3p aacgcaggcCGCTTTattc
 0 CAAAGCGC m6b Disrupted -0.080000 no TS 3.240000
hsa-miR-518f-3p aacgcaggcCGCTTTattc
 0 GAAAGCGC m6b Disrupted -0.080000 no TS 3.040000
hsa-miR-596 aacGCAGGCTgctttattc
 0 AAGCCUGC m7b (m6b->m7b) no TS -0.116000 -1.440000


Mutation Mutation ID Sample Name Cancer Type
chr22:g.48751037G>A COSN14583288 8067507 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr22:g.48751240C>T COSN8566780 tumor_4120193 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4529-5p gccagttGATGGCCcttct
 0 AGGCCAUC m7b Created no TS -0.148000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr22:g.48751245C>A COSN8612872 J13_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3154 ttgacggCCCTTCTcccca
 0 CAGAAGGG m7b Disrupted 0.034000 no TS No effect
hsa-miR-4434 ttgacggccCTTCTCCcca
 1
 AGGAGAAG m7b (m7b->m6c) -0.003000 -0.057000 0.010000
hsa-miR-4516 ttgacggccCTTCTCCCca
 1
 GGGAGAAG m8a (m8a->m7b) 0.009000 -0.054000 0.290000
hsa-miR-5703 ttgacggccCTTCTCCcca
 1
 AGGAGAAG m7b (m7b->m6c) 0.000000 -0.054000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr22:g.48751450C>A COSN8612873 J30_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1269a cctatgAGTCCAattaaca
 12
 CUGGACUG m6b Disrupted -0.150000 no TS 0.130000
hsa-miR-1269b cctatgAGTCCAattaaca
 12
 CUGGACUG m6b Disrupted -0.147000 no TS 0.550000
hsa-miR-4529-3p cctatgAGTCCAATtaaca
 12
 AUUGGACU m8a Disrupted -0.175000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr22:g.48751750C>A COSN10031921 C0092T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2467-3p cagCCTCTGCcagccagcg
 0 AGCAGAGG m7b (m7b->m6b) -0.063000 no TS No effect
hsa-miR-3652 cagcctctgCCAGCCagcg
 0 CGGCUGGA m6b Disrupted -0.214000 -0.116000 No effect
hsa-miR-4430 cagcctctgCCAGCCagcg
 0 AGGCUGGA m6b Disrupted -0.211000 -0.116000 No effect
hsa-miR-4505 cagcctctgCCAGCCagcg
 0 AGGCUGGG m6b Disrupted -0.215000 -0.125000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
48750116 rs131959 C C hsa-miR-185-3p
hsa-miR-3178
hsa-miR-4486
hsa-miR-4492
hsa-miR-4498
hsa-miR-4505
hsa-miR-5001-5p
hsa-miR-5787
hsa-miR-762
3
1
1
2
2
1
9
1
2
 cgcgccCAGCCCC
CGCGCCCAgcccc
cgCGCCCAGcccc
cgcgcCCAGCCCc
cgcgcCCAGCCCc
cgcgCCCAGCCcc
cgcgcCCAGCCCc
cgcgCCCAGCCcc
cgcgcCCAGCCCc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 -0.054
-0.439
-0.073
-0.084
-0.056
-0.049
-0.074
-0.067
-0.084
A hsa-miR-4634
2
 CGCGCCAagcccc
 Created
N
 -0.228
48750261 rs201071872 C C hsa-miR-4695-5p
hsa-miR-6089
hsa-miR-7106-5p
hsa-miR-765
3
1
1
2
 cgGCCTCCTcccg
CGGCCTCctcccg
cggccTCCTCCCg
cggcCTCCTCCcg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.044
-0.132
-0.066
-0.041
T hsa-miR-4434
hsa-miR-4493
hsa-miR-4516
hsa-miR-5703
hsa-miR-6746-5p
hsa-miR-6770-5p
hsa-miR-6878-5p
2
2
2
2
14
3
1
 cggcCTTCTCCcg
cGGCCTTCtcccg
cggcCTTCTCCcg
cggcCTTCTCCcg
cggcctTCTCCCG
cggCCTTCTCccg
cggccTTCTCCCg
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 0.036
-0.098
0.018
0.027
-0.168
-0.03
-0.008
48750487 rs695689 G G hsa-miR-2277-5p
hsa-miR-4479
1
1
 cCCCGCGCAccct
ccCCGCGCAccct
 Disrupted
Disrupted
N
N
 -0.426
-0.21
A hsa-miR-147b
hsa-miR-4455
hsa-miR-4706
hsa-miR-4749-5p
hsa-miR-744-5p
1
1
1
1
1
 ccCCGCACAccct
ccccgCACACCCt
CCCCGCAcaccct
CCCCGCAcaccct
CCCCGCAcaccct
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.121
-0.009
-0.157
-0.147
-0.141
48751453 rs16999841 A A hsa-miR-1269a
hsa-miR-1269b
hsa-miR-2053
hsa-miR-4529-3p
hsa-miR-5009-5p
hsa-miR-569
hsa-miR-8058
12
12
14
12
12
14
12
 AGTCCAAttaaca
AGTCCAAttaaca
agtccaATTAACA
AGTCCAAttaaca
AGTCCAAttaaca
agtccaATTAACA
AGTCCAAttaaca
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.15
-0.147
-0.056
-0.175
-0.151
0.015
-0.148
G hsa-miR-3654
hsa-miR-378a-3p
hsa-miR-378b
hsa-miR-378c
hsa-miR-378d
hsa-miR-378e
hsa-miR-378f
hsa-miR-378h
hsa-miR-378i
hsa-miR-422a
hsa-miR-582-3p
14
12
12
12
12
12
12
12
12
12
14
 aGTCCAGTtaaca
AGTCCAGttaaca
AGTCCAGttaaca
AGTCCAGttaaca
AGTCCAGttaaca
AGTCCAGttaaca
AGTCCAGttaaca
AGTCCAGttaaca
AGTCCAGttaaca
AGTCCAGttaaca
agtCCAGTTAaca
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
 -0.245
-0.193
-0.203
-0.193
-0.193
-0.193
-0.184
-0.193
-0.193
-0.203
-0.09

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