SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000137
Gene Symbol: FAH
Description: Homo sapiens fumarylacetoacetate hydrolase (fumarylacetoacetase) (FAH), mRNA.
Gene Location: chr15(+):80445232-80478924
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr15:g.80186258C>- ICGC_ssm_v3_77576 HCC139T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-296-3p ccctttCAACCCTgtgact
0 GAGGGUUG m7b Disrupted -0.211000 no TS 1.800000
hsa-miR-513a-5p ccctttcaaCCTGTGAct
0 UUCACAGG m7b (m6c->m7b) -0.114000 -0.149000 2.100000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.80186347G>A COSN1685525 RK065_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-34a-5p tgCACTGCCAcagatgcag
0 UGGCAGUG m8a (m7a->m8a) -0.144000 -0.342000 0.130000
hsa-miR-3688-5p tgcacTGCCACagatgcag
0 AGUGGCAA m6b Created no TS -0.145000 -0.700000
hsa-miR-449a tgCACTGCCAcagatgcag
0 UGGCAGUG m8a (m7a->m8a) -0.135000 -0.332000 0.130000
hsa-miR-4734 tgcactgCCGCAGatgcag
0 GCUGCGGG m6b Disrupted -0.215000 no TS 1.650000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
80186258 rs200464452 - C hsa-miR-296-3p
hsa-miR-6823-5p
2
2
tttCAACCCTgtg
tttcAACCCTGtg
Unknown
Unknown
N
N
-0.211
-0.197
-

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