SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_172105
Gene Symbol: EYA4
Description: Homo sapiens eyes absent homolog 4 (Drosophila) (EYA4), transcript variant 1, mRNA.
Gene Location: chr6(+):133562494-133853258
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.133528828C>T COSN14689464 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3121-3p ccggagaTCTATTTtttat
 2
 UAAAUAGA m7b Created 0.042000 -0.091000 -7.640000
hsa-miR-4694-3p ccggagaTCCATTTtttat
 0 CAAAUGGA m7b Disrupted -0.180000 no TS 1.040000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133529285T>G COSN15196148 SM-4AX84 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-323a-3p acatGTAATGTGtgtaaat
 0 CACAUUAC m8a Created no TS -0.126000 No effect
hsa-miR-329 acatgtaatGTGTGTaaat
 9
 AACACACC m6b Created 0.053000 -0.071000 No effect
hsa-miR-362-3p acatgtaatGTGTGTaaat
 9
 AACACACC m6b Created 0.060000 -0.064000 -0.020000
hsa-miR-3941 acatgtaatGTGTGTAAat
 20
 UUACACAC m8a (m7b->m8a) 0.000000 -0.201000 No effect
hsa-miR-4719 acatgtaATTTGTGtaaat
 4
 UCACAAAU m7b Disrupted -0.081000 0.045000 0.010000
hsa-miR-4801 acatgtaatTTGTGTAaat
 19
 UACACAAG m7a (m7a->m6b) -0.149000 -0.072000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133529718C>T COSN15098591 LP6005409-DNA_E02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7i-3p aactatTTGCGCAtccaac
 2
 CUGCGCAA m7b Disrupted -0.373000 -0.103000 1.830000
hsa-miR-4719 aactATTTGTGcatccaac
 4
 UCACAAAU m7b Created -0.081000 -0.054000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133529873C>G COSN6588892 ICGC_MB92 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1323 aggttgagAGTTTTGAtat
 3
 UCAAAACU m8a Created 0.105000 0.181000 0.060000
hsa-miR-3184-3p aggttGAGACTTTtgatat
 2
 AAAGUCUC m8a Disrupted -0.095000 no TS 0.448000
hsa-miR-548a-3p aggttgagAGTTTTGatat
 3
 CAAAACUG m7a Created 0.120000 0.120000 0.020000
hsa-miR-548n aggttgagACTTTTGatat
 0 CAAAAGUA m7a Disrupted NA NA 0.710000
hsa-miR-548o-3p aggttgagAGTTTTGatat
 3
 CCAAAACU m7b Created 0.105000 0.181000 -0.010000
hsa-miR-548t-5p aggttgagACTTTTGatat
 0 CAAAAGUG m7a Disrupted NA NA 1.630000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530249C>T COSN9297562 AOCS-120-3-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p acagacTTGTATAtgtttg
 11
 CUAUACAA m7b Created 0.021000 0.123000 No effect
hsa-let-7b-3p acagacTTGTATAtgtttg
 11
 CUAUACAA m7b Created 0.017000 0.138000 No effect
hsa-let-7f-1-3p acagacTTGTATAtgtttg
 11
 CUAUACAA m7b Created 0.017000 0.157000 No effect
hsa-miR-300 acagaCTTGTATAtgtttg
 0 UAUACAAG m8a Created no TS 0.115000 No effect
hsa-miR-381 acagaCTTGTATAtgtttg
 0 UAUACAAG m8a Created no TS 0.146000 No effect
hsa-miR-4666a-3p acagacTTGTATatgtttg
 8
 CAUACAAU m6b Created 0.022000 0.143000 No effect
hsa-miR-5580-3p acagacttgCATATGTttg
 17
 CACAUAUG m7b (m7b->m6c) -0.003000 -0.095000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530456G>T COSN2142357 RK112_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-298 ttttatggtTTCTGCacct
 0 AGCAGAAG m6b Created no TS 0.064000 -1.330000
hsa-miR-3166 ttttatggTGTCTGCacct
 7
 CGCAGACA m7b Disrupted -0.015000 no TS 0.030000
hsa-miR-4771 ttttatggtGTCTGCacct
 7
 AGCAGACU m6b Disrupted -0.012000 no TS 0.300000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530517G>C COSN9297563 AOCS-113-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-325 aggCTACTAGtcagtgccc
 2
 CCUAGUAG m7b (m7b->m6b) 0.045000 no TS 6.750000
hsa-miR-3923 aggcTACTAGTcagtgccc
 1
 AACUAGUA m7b Disrupted 0.123000 no TS 0.760000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530686A>C COSN8493692 J88_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-494 gccATGTTTCtattgggta
 0 UGAAACAU m7b (m6b->m7b) 0.009000 0.149000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133531107G>A COSN14681072 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20a-3p agtctgtggATGCAGaaag
 3
 ACUGCAUU m6b Created 0.062000 0.041000 -6.320000
hsa-miR-3130-3p agtctgtgGGTGCAGaaag
 5
 GCUGCACC m7b Disrupted -0.334000 -0.099000 4.660000
hsa-miR-324-5p agtctgtGGATGCagaaag
 20
 CGCAUCCC m6b Created -0.152000 -0.223000 -0.760000
hsa-miR-4793-3p agtctgtggGTGCAGAaag
 7
 UCUGCACU m7a (m7a->m6b) -0.045000 no TS 0.340000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133531246C>T COSN7690067 8047835 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-136-5p caaggttgATGGAGaacag
 0 ACUCCAUU m6b Created -0.179000 -0.217000 -0.520000
hsa-miR-3605-3p caaggttgACGGAGaacag
 3
 CCUCCGUG m6b Disrupted -0.143000 no TS 17.270000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133531661C>A COSN7690068 8050103 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1909-3p atgCCCCTGCaaaattttg
 3
 CGCAGGGG m7b (m7b->m6b) -0.454000 no TS 6.460000
hsa-miR-30a-3p atgcccCTGAAAaattttg
 6
 CUUUCAGU m6b Created 0.017000 0.001000 No effect
hsa-miR-30d-3p atgcccCTGAAAaattttg
 6
 CUUUCAGU m6b Created 0.013000 -0.003000 -0.010000
hsa-miR-30e-3p atgcccCTGAAAaattttg
 6
 CUUUCAGU m6b Created 0.017000 0.001000 No effect
hsa-miR-3127-5p atgcCCCTGAaaaattttg
 13
 AUCAGGGC m6b Created -0.233000 -0.392000 -0.010000
hsa-miR-557 atgccccTGCAAAattttg
 6
 GUUUGCAC m6b Disrupted -0.046000 no TS 0.320000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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