SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_004100
Gene Symbol: EYA4
Description: Homo sapiens eyes absent homolog 4 (Drosophila) (EYA4), transcript variant 1, mRNA.
Gene Location: chr6(+):133562494-133853258
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.133528828C>T COSN14689464 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3121-3p ccggagaTCTATTTtttat
 2
 UAAAUAGA m7b Created 0.042000 -0.091000 -7.640000
hsa-miR-4694-3p ccggagaTCCATTTtttat
 0 CAAAUGGA m7b Disrupted -0.180000 no TS 1.040000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133529285T>G COSN15196148 SM-4AX84 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-323a-3p acatGTAATGTGtgtaaat
 0 CACAUUAC m8a Created no TS -0.126000 No effect
hsa-miR-329 acatgtaatGTGTGTaaat
 9
 AACACACC m6b Created 0.053000 -0.071000 No effect
hsa-miR-362-3p acatgtaatGTGTGTaaat
 9
 AACACACC m6b Created 0.060000 -0.064000 -0.020000
hsa-miR-3941 acatgtaatGTGTGTAAat
 20
 UUACACAC m8a (m7b->m8a) 0.000000 -0.201000 No effect
hsa-miR-4719 acatgtaATTTGTGtaaat
 4
 UCACAAAU m7b Disrupted -0.081000 0.045000 0.010000
hsa-miR-4801 acatgtaatTTGTGTAaat
 19
 UACACAAG m7a (m7a->m6b) -0.149000 -0.072000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133529718C>T COSN15098591 LP6005409-DNA_E02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7i-3p aactatTTGCGCAtccaac
 2
 CUGCGCAA m7b Disrupted -0.373000 -0.103000 1.830000
hsa-miR-4719 aactATTTGTGcatccaac
 4
 UCACAAAU m7b Created -0.081000 -0.054000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133529873C>G COSN6588892 ICGC_MB92 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1323 aggttgagAGTTTTGAtat
 3
 UCAAAACU m8a Created 0.105000 0.181000 0.060000
hsa-miR-3184-3p aggttGAGACTTTtgatat
 2
 AAAGUCUC m8a Disrupted -0.095000 no TS 0.448000
hsa-miR-548a-3p aggttgagAGTTTTGatat
 3
 CAAAACUG m7a Created 0.120000 0.120000 0.020000
hsa-miR-548n aggttgagACTTTTGatat
 0 CAAAAGUA m7a Disrupted NA NA 0.710000
hsa-miR-548o-3p aggttgagAGTTTTGatat
 3
 CCAAAACU m7b Created 0.105000 0.181000 -0.010000
hsa-miR-548t-5p aggttgagACTTTTGatat
 0 CAAAAGUG m7a Disrupted NA NA 1.630000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530249C>T COSN9297562 AOCS-120-3-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p acagacTTGTATAtgtttg
 11
 CUAUACAA m7b Created 0.021000 0.123000 No effect
hsa-let-7b-3p acagacTTGTATAtgtttg
 11
 CUAUACAA m7b Created 0.017000 0.138000 No effect
hsa-let-7f-1-3p acagacTTGTATAtgtttg
 11
 CUAUACAA m7b Created 0.017000 0.157000 No effect
hsa-miR-300 acagaCTTGTATAtgtttg
 0 UAUACAAG m8a Created no TS 0.115000 No effect
hsa-miR-381 acagaCTTGTATAtgtttg
 0 UAUACAAG m8a Created no TS 0.146000 No effect
hsa-miR-4666a-3p acagacTTGTATatgtttg
 8
 CAUACAAU m6b Created 0.022000 0.143000 No effect
hsa-miR-5580-3p acagacttgCATATGTttg
 17
 CACAUAUG m7b (m7b->m6c) -0.003000 -0.095000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530456G>T COSN2142357 RK112_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-298 ttttatggtTTCTGCacct
 0 AGCAGAAG m6b Created no TS 0.064000 -1.330000
hsa-miR-3166 ttttatggTGTCTGCacct
 7
 CGCAGACA m7b Disrupted -0.015000 no TS 0.030000
hsa-miR-4771 ttttatggtGTCTGCacct
 7
 AGCAGACU m6b Disrupted -0.012000 no TS 0.300000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530517G>C COSN9297563 AOCS-113-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-325 aggCTACTAGtcagtgccc
 2
 CCUAGUAG m7b (m7b->m6b) 0.045000 no TS 6.750000
hsa-miR-3923 aggcTACTAGTcagtgccc
 1
 AACUAGUA m7b Disrupted 0.123000 no TS 0.760000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133530686A>C COSN8493692 J88_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-494 gccATGTTTCtattgggta
 0 UGAAACAU m7b (m6b->m7b) 0.009000 0.149000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133531107G>A COSN14681072 CHC433T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-20a-3p agtctgtggATGCAGaaag
 3
 ACUGCAUU m6b Created 0.062000 0.041000 -6.320000
hsa-miR-3130-3p agtctgtgGGTGCAGaaag
 5
 GCUGCACC m7b Disrupted -0.334000 -0.099000 4.660000
hsa-miR-324-5p agtctgtGGATGCagaaag
 20
 CGCAUCCC m6b Created -0.152000 -0.223000 -0.760000
hsa-miR-4793-3p agtctgtggGTGCAGAaag
 7
 UCUGCACU m7a (m7a->m6b) -0.045000 no TS 0.340000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133531246C>T COSN7690067 8047835 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-136-5p caaggttgATGGAGaacag
 0 ACUCCAUU m6b Created -0.179000 -0.217000 -0.520000
hsa-miR-3605-3p caaggttgACGGAGaacag
 3
 CCUCCGUG m6b Disrupted -0.143000 no TS 17.270000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.133531661C>A COSN7690068 8050103 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1909-3p atgCCCCTGCaaaattttg
 3
 CGCAGGGG m7b (m7b->m6b) -0.454000 no TS 6.460000
hsa-miR-30a-3p atgcccCTGAAAaattttg
 6
 CUUUCAGU m6b Created 0.017000 0.001000 No effect
hsa-miR-30d-3p atgcccCTGAAAaattttg
 6
 CUUUCAGU m6b Created 0.013000 -0.003000 -0.010000
hsa-miR-30e-3p atgcccCTGAAAaattttg
 6
 CUUUCAGU m6b Created 0.017000 0.001000 No effect
hsa-miR-3127-5p atgcCCCTGAaaaattttg
 13
 AUCAGGGC m6b Created -0.233000 -0.392000 -0.010000
hsa-miR-557 atgccccTGCAAAattttg
 6
 GUUUGCAC m6b Disrupted -0.046000 no TS 0.320000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
133528828 rs3734279 C C hsa-miR-4694-3p
7
 gagaTCCATTTtt
 Disrupted
N
 -0.18
T hsa-miR-3121-3p
hsa-miR-7161-3p
7
6
 gagaTCTATTTtt
gAGATCTAttttt
 Created
Created
N
N
 -0.133
-0.119
133531107 rs41286208 G G hsa-miR-3130-3p
hsa-miR-4793-3p
7
7
 ctgtgGGTGCAGA
ctgtggGTGCAGA
 Disrupted
Disrupted
N
N
 -0.235
-0.045
A hsa-miR-20a-3p
hsa-miR-324-5p
7
1
 ctgtggATGCAGA
ctgtGGATGCAga
 Created
Created
N
N
 -0.021
-0.071
133531279 rs201389132 A A hsa-miR-2861
hsa-miR-3130-3p
hsa-miR-767-5p
4
5
5
 tggtgCAGGCCCA
tGGTGCAGgccca
TGGTGCAggccca
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.22
-0.099
-0.114
C hsa-miR-593-5p
hsa-miR-6781-5p
hsa-miR-6877-5p
5
4
4
 TGGTGCCggccca
tggtgCCGGCCCA
tggtgcCGGCCCA
 Created
Created
Created
N
N
N
 -0.106
-0.353
-0.171

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