SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_005239
Gene Symbol: ETS2
Description: Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (ETS2), transcript variant 1, mRNA.
Gene Location: chr21(+):40177848-40196878
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr21:g.38823346A>G COSN9158611 AOCS-130-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p agtTTGTATAtattattat
0 CUAUACAA m7b (m7b->m6b) -0.272000 -0.153000 0.500000
hsa-let-7b-3p agtTTGTATAtattattat
0 CUAUACAA m7b (m7b->m6b) -0.253000 -0.134000 0.540000
hsa-let-7f-1-3p agtTTGTATAtattattat
0 CUAUACAA m7b (m7b->m6b) -0.224000 -0.115000 0.540000
hsa-miR-1185-1-3p agttTGTATATattattat
0 AUAUACAG m7a Disrupted NA NA 0.050000
hsa-miR-1185-2-3p agttTGTATATattattat
0 AUAUACAG m7a Disrupted NA NA 0.410000
hsa-miR-1277-5p agtttgtATATATTattat
7
AAAUAUAU m7b Disrupted -0.039000 no TS 0.200000
hsa-miR-369-3p agtttgtatGTATTATTat
3
AAUAAUAC m8a (m7b->m8a) -0.051000 -0.149000 -0.600000
hsa-miR-374c-5p agtttgtaTGTATTATtat
6
AUAAUACA m8a Created -0.081000 -0.234000 -1.510000
hsa-miR-5011-5p agtttgTATATATtattat
11
UAUAUAUA m7b Disrupted -0.014000 no TS 0.260000
hsa-miR-5692b agtttgtatATATTATTat
3
AAUAAUAU m8a (m8a->m7b) -0.015000 0.058000 -0.080000
hsa-miR-5692c agtttgtatATATTATTat
3
AAUAAUAU m8a (m8a->m7b) -0.015000 0.058000 -0.020000
hsa-miR-655 agtttgtaTGTATTATtat
6
AUAAUACA m8a Created -0.091000 -0.244000 -2.510000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.38823684T>C COSN5136317 PD3904a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3973 caaggACTTTGTacatttg
0 ACAAAGUA m7a Disrupted NA NA 0.010000
hsa-miR-520d-5p caaggaCTTTGTAcatttg
10
CUACAAAG m7b Disrupted 0.031000 0.027000 0.140000
hsa-miR-520g caaggACTTTGTacatttg
0 ACAAAGUG m7a Disrupted NA NA 2.840000
hsa-miR-520h caaggACTTTGTacatttg
0 ACAAAGUG m7a Disrupted NA NA 3.890000
hsa-miR-524-5p caaggaCTTTGTAcatttg
10
CUACAAAG m7b Disrupted 0.043000 0.020000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr21:g.38823695G>A COSN4783778 tumor_4170686 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-150-5p tacatTTGGGAGtttttat
2
UCUCCCAA m7b Disrupted -0.200000 no TS 0.220000
hsa-miR-186-3p tacaTTTGGGagtttttat
8
GCCCAAAG m6b Disrupted -0.010000 no TS -0.200000
hsa-miR-5582-3p tacatttggAAGTTTTtat
0 UAAAACUU m7b (m6c->m7b) no TS 0.043000 -0.190000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
38823353 rs530 T T hsa-miR-369-3p
hsa-miR-374a-5p
hsa-miR-374b-5p
hsa-miR-5692b
hsa-miR-5692c
3
3
3
3
3
tatTATTATAatc
tatTATTATAAtc
tatTATTATAAtc
tatTATTATAatc
tatTATTATAatc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
0.005
0.003
0.024
0.027
0.027
A hsa-miR-126-5p
hsa-miR-4795-3p
4
4
tattaTAATAATc
tattATAATAAtc
Created
Created
N
N
-0.054
0.024
38823695 rs184055024 G G hsa-miR-150-5p
hsa-miR-186-3p
2
8
atTTGGGAGtttt
aTTTGGGAgtttt
Disrupted
Disrupted
N
N
-0.2
-0.01

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