| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_001122742 |
|---|---|
| Gene Symbol: | ESR1 |
| Description: | Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1, mRNA. |
| Gene Location: | chr6(+):152011630-152424408 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.152100144C>G | COSN6308977 | RK128_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-186-3p |
cgcattgccCTTTGGGggt |
0 | GCCCAAAG | m7b | (m7b->m6c) | 0.120000 | no TS |
2.670000 |
|
| hsa-miR-4445-3p |
cgcaTTGCCGTttgggggt |
0 | CACGGCAA | m7b | Created | -0.211000 | -0.270000 | No effect | |
| hsa-miR-548al |
cgcaTTGCCGTTtgggggt |
0 | AACGGCAA | m8a | Created | -0.180000 | -0.248000 |
-3.040000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.152101919T>C | COSN9497603 | AOCS-091-3-0 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1251 |
cttcagttCTAGAGaagaa |
0 | ACUCUAGC | m6b | Disrupted | -0.025000 | -0.017000 | No effect | |
| hsa-miR-1299 |
cttcagTTCCAGAgaagaa |
0 | UUCUGGAA | m7b | Created | no TS | 0.040000 |
-0.050000 |
|
| hsa-miR-3191-5p |
cttcagttCCAGAGAagaa |
10 |
CUCUCUGG | m7b | Created | 0.066000 | 0.004000 | No effect | |
| hsa-miR-326 |
cttcagttCCAGAGaagaa |
0 | CCUCUGGG | m6b | Created | no TS | -0.005000 |
-0.010000 |
|
| hsa-miR-330-5p |
cttcagttCCAGAGAagaa |
0 | UCUCUGGG | m7a | Created | no TS | -0.005000 |
-1.210000 |
|
| hsa-miR-4684-5p |
cttcagttcTAGAGAagaa |
2 |
CUCUCUAC | m6b | Disrupted | -0.030000 | -0.076000 | No effect | |
| hsa-miR-517-5p |
cttcagtTCTAGAGaagaa |
0 | CCUCUAGA | m7b | Disrupted | -0.103000 | -0.011000 |
0.490000 |
|
| hsa-miR-518c-5p |
cttcagtTCCAGAGAagaa |
0 | UCUCUGGA | m8a | Created | no TS | -0.113000 |
-3.380000 |
|
| hsa-miR-518d-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.160000 |
|
| hsa-miR-518e-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.450000 |
|
| hsa-miR-518f-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.300000 |
|
| hsa-miR-519a-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.450000 |
|
| hsa-miR-519b-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.450000 |
|
| hsa-miR-519c-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.450000 |
|
| hsa-miR-520c-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.160000 |
|
| hsa-miR-522-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.450000 |
|
| hsa-miR-523-5p |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.450000 |
|
| hsa-miR-526a |
cttcagtTCTAGAGaagaa |
0 | CUCUAGAG | m7a | Disrupted | NA | NA |
0.160000 |
|
| hsa-miR-875-3p |
cttcagTTCCAGagaagaa |
0 | CCUGGAAA | m6b | Created | no TS | 0.037000 |
-0.840000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr6:g.152101993T>C | COSN14778636 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1285-3p |
gccatTGCCCAGcttgccg |
0 | UCUGGGCA | m7b | Created | no TS | -0.060000 |
-0.500000 |
|
| hsa-miR-3187-5p |
gccatTGCCCAGcttgccg |
0 | CCUGGGCA | m7b | Created | no TS | -0.079000 |
-0.030000 |
|
| hsa-miR-320e |
gccattgcCCAGCTTgccg |
0 | AAAGCUGG | m7b | Created | no TS | 0.026000 |
-0.010000 |
|
| hsa-miR-5189 |
gccatTGCCCAGcttgccg |
0 | UCUGGGCA | m7b | Created | no TS | -0.088000 |
-3.410000 |
|
| hsa-miR-612 |
gccatTGCCCAGCttgccg |
0 | GCUGGGCA | m8a | Created | no TS | -0.060000 |
-0.030000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr6:g.152103185G>A | COSN4953484 | SS6003131 | [oesophagus][NS][carcinoma][adenocarcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-106a-5p |
acctcttttGCACTTTgaa |
0 | AAAAGUGC | m7b | (m7b->m6c) | -0.387000 | -0.199000 | No effect |
| hsa-miR-106b-5p |
acctcttttGCACTTTgaa |
0 | UAAAGUGC | m7b | (m7b->m6c) | -0.387000 | -0.199000 |
0.030000 |
| hsa-miR-130a-3p |
acctcttTTGCACTttgaa |
2 |
CAGUGCAA | m7b | Disrupted | -0.553000 | -0.340000 |
0.230000 |
| hsa-miR-130b-3p |
acctcttTTGCACTttgaa |
2 |
CAGUGCAA | m7b | Disrupted | -0.582000 | -0.351000 |
0.020000 |
| hsa-miR-17-5p |
acctcttttGCACTTTGaa |
0 | CAAAGUGC | m8a | (m8a->m7b) | -0.387000 | -0.199000 | No effect |
| hsa-miR-19a-3p |
acctctTTTGCACtttgaa |
17 |
UGUGCAAA | m7b | Disrupted | -0.364000 | -0.160000 |
4.690000 |
| hsa-miR-19b-3p |
acctctTTTGCACtttgaa |
17 |
UGUGCAAA | m7b | Disrupted | -0.364000 | -0.160000 |
4.390000 |
| hsa-miR-20a-5p |
acctcttttGCACTTTgaa |
0 | UAAAGUGC | m7b | (m7b->m6c) | -0.377000 | -0.189000 |
0.010000 |
| hsa-miR-20b-5p |
acctcttttGCACTTTGaa |
0 | CAAAGUGC | m8a | (m8a->m7b) | -0.377000 | -0.189000 |
0.370000 |
| hsa-miR-301a-3p |
acctcttTTGCACTttgaa |
2 |
CAGUGCAA | m7b | Disrupted | -0.589000 | -0.358000 |
0.450000 |
| hsa-miR-301b |
acctcttTTGCACTttgaa |
2 |
CAGUGCAA | m7b | Disrupted | -0.589000 | -0.358000 |
2.430000 |
| hsa-miR-3666 |
acctcttTTGCACTttgaa |
2 |
CAGUGCAA | m7b | Disrupted | -0.567000 | -0.326000 |
0.010000 |
| hsa-miR-4295 |
acctcttTTGCACTttgaa |
2 |
CAGUGCAA | m7b | Disrupted | -0.540000 | -0.309000 |
0.020000 |
| hsa-miR-454-3p |
acctcttTTGCACTttgaa |
2 |
UAGUGCAA | m7b | Disrupted | -0.567000 | -0.326000 |
0.200000 |
| hsa-miR-519a-3p |
acctctttTGCACTTTgaa |
2 |
AAAGUGCA | m8a | Disrupted | -0.282000 | -0.028000 |
0.070000 |
| hsa-miR-519b-3p |
acctctttTGCACTTTgaa |
2 |
AAAGUGCA | m8a | Disrupted | -0.282000 | -0.028000 |
0.580000 |
| hsa-miR-519c-3p |
acctctttTGCACTTTgaa |
2 |
AAAGUGCA | m8a | Disrupted | -0.282000 | -0.028000 |
0.740000 |
| hsa-miR-519d |
acctcttttGCACTTTGaa |
0 | CAAAGUGC | m8a | (m8a->m7b) | -0.384000 | -0.177000 |
0.070000 |
| hsa-miR-526b-3p |
acctcttttGCACTTTgaa |
0 | GAAAGUGC | m7b | (m7b->m6c) | -0.406000 | -0.199000 | No effect |
| hsa-miR-548aj-5p |
acctCTTTTGCActttgaa |
15 |
UGCAAAAG | m8a | Disrupted | -0.327000 | -0.077000 |
0.190000 |
| hsa-miR-548aw |
acctcTTTTGCACtttgaa |
17 |
GUGCAAAA | m8a | Disrupted | -0.213000 | -0.130000 |
0.590000 |
| hsa-miR-548g-5p |
acctCTTTTGCActttgaa |
15 |
UGCAAAAG | m8a | Disrupted | -0.327000 | -0.077000 |
0.190000 |
| hsa-miR-548x-5p |
acctCTTTTGCActttgaa |
15 |
UGCAAAAG | m8a | Disrupted | -0.327000 | -0.077000 |
0.190000 |
| hsa-miR-93-5p |
acctcttttGCACTTTGaa |
0 | CAAAGUGC | m8a | (m8a->m7b) | -0.377000 | -0.189000 |
0.090000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 152101510 | rs143354689 | G | G |
hsa-miR-18a-3p hsa-miR-1913 hsa-miR-2117 hsa-miR-3191-5p hsa-miR-324-3p hsa-miR-4273 hsa-miR-6728-3p hsa-miR-7156-5p |
13 13 8 10 13 8 11 8 |
tGGGCAGAgaaca tGGGCAGAgaaca tgggcAGAGAACA tgggCAGAGAAca tGGGCAGAgaaca tgggcaGAGAACA tggGCAGAGAaca tgggcaGAGAACA |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
LT N N N N N N N |
-0.031 -0.036 0.085 0.066 -0.036 0.048 0.006 0.057 |
| A |
hsa-miR-2116-5p hsa-miR-22-5p hsa-miR-4677-5p hsa-miR-6844 |
8 8 8 10 |
tgggcaAAGAACA tgggcaAAGAACA tgggcaAAGAACA tgggCAAAGAAca |
Created Created Created Created |
N LT N N |
0.113 0.105 0.074 0.111 |
|||
| 152101993 | rs9341077 | T | |||||||
| C |
hsa-miR-1285-3p hsa-miR-3187-5p hsa-miR-320e hsa-miR-5189-5p hsa-miR-612 hsa-miR-6860 |
6 6 10 6 6 6 |
atTGCCCAGcttg atTGCCCAGcttg attgcCCAGCTTg atTGCCCAGcttg atTGCCCAGcttg atTGCCCAGcttg |
Created Created Created Created Created Created |
N N N N N N |
-0.06 -0.079 0.026 -0.088 -0.06 -0.06 |