SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000124
Gene Symbol:	ERCC6
Description:	Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6), mRNA.
Gene Location:	chr10(-):50664490-50747147
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.49457119G>A			COSN5875651		RK187_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1295b-3p	taatcattaGCCTATaagg	4	AAUAGGCC	m6b	Disrupted	-0.142000	no TS	1.510000
hsa-miR-569	taatCATTAACctataagg	0	AGUUAAUG	m7b	Created	no TS	-0.104000	-0.500000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.49457844C>G			COSN5875652		RK220_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-921	tgtttgtatCTCACTActg	1	CUAGUGAG	m7b	(m7b->m6b)	-0.108000	no TS	3.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.49458407A>G			COSN1490992		RK007_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4724-5p	acctGTTCAGTaagttcat	0	AACUGAAC	m7b	Created	no TS	-0.255000	No effect
hsa-miR-4724-5p	acctGTTCAGTaagttcat	0	AACUGAAC	m7b	Created	no TS	-0.255	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.49458583T>-			ICGC_ssm_v3_24605		HCC100T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-192-3p	ttttttttTTGGCAatcta	0	CUGCCAAU	m6b	Disrupted	-0.179000	-0.178000	-0.270000
hsa-miR-3613-3p	ttttTTTTTTGgcaatcta	0	ACAAAAAA	m7b	Disrupted	0.174000	0.176000	-0.410000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
49457119	rs192300032	G	G	hsa-miR-1295b-3p	4	tcattaGCCTATA	Disrupted	N	-0.142

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