| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_001166049 |
|---|---|
| Gene Symbol: | ERCC1 |
| Description: | Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) (ERCC1), transcript variant 3, mRNA. |
| Gene Location: | chr19(-):45910590-45927177 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr19:g.45408924T>C | ICGC_1440095 | TCGA-AP-A0LM-01A-11D-A122-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1275 |
atggctTCCCCCAgtggct |
0 | GUGGGGGA | m7b | Created | -0.061 | -0.148 | No effect | |
| hsa-miR-3928 |
atggcTTCCTCCagtggct |
0 | GGAGGAAC | m7a | Disrupted | -0.368 | -0.368 |
1.8 |
|
| hsa-miR-4271 |
atggCTTCCCCCagtggct |
0 | GGGGGAAG | m8a | Created | no TS | -0.015 | No effect | |
| hsa-miR-4525 |
atggctTCCCCCagtggct |
0 | GGGGGGAU | m6b | Created | no TS | -0.088 | No effect | |
| hsa-miR-4665-5p |
atggctTCCCCCAGtggct |
0 | CUGGGGGA | m8a | Created | -0.061 | -0.139 | No effect | |
| hsa-miR-4725-3p |
atggCTTCCCCcagtggct |
0 | UGGGGAAG | m7b | Created | no TS | -0.015 | No effect | |
| hsa-miR-5010-5p |
atggctTCCCCCagtggct |
0 | AGGGGGAU | m6b | Created | no TS | -0.078 |
0.01 |
|
| hsa-miR-625-5p |
atggcTTCCCCCagtggct |
0 | AGGGGGAA | m7b | Created | no TS | -0.138 | No effect | |
| hsa-miR-637 |
atggcttCCCCCAGTggct |
0 | ACUGGGGG | m8a | Created | -0.435 | -0.583 | No effect | |
| hsa-miR-671-5p |
atGGCTTCCTccagtggct |
0 | AGGAAGCC | m8a | (m8a->m7b) | -0.093 | -0.066 | No effect | |
| hsa-miR-766-5p |
atggcTTCCTCCagtggct |
0 | AGGAGGAA | m7b | Disrupted | -0.065 | no TS |
0.02 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr19:g.45409063C>T | ICGC_1440096 | TCGA-AX-A0J1-01A-11W-A062-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-183-5p |
ctgttgagGTGCCATggtc |
0 | UAUGGCAC | m7b | Created | no TS | -0.039 |
-0.01 |
|
| hsa-miR-566 |
ctgttgAGGCGCCatggtc |
0 | GGGCGCCU | m7b | Disrupted | -0.409 | no TS |
0.01 |
|
| hsa-miR-593-5p |
ctgttgaGGTGCCatggtc |
0 | AGGCACCA | m6b | Created | no TS | -0.116 |
-7.62 |
|
| hsa-miR-652-3p |
ctgttgagGCGCCATggtc |
0 | AAUGGCGC | m7b | Disrupted | -0.159 | no TS |
0.12 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr19:g.45409255G>G | ICGC_64548 | TCGA-GV-A3JX-01A-11D-A20D-08 | BladderUrothelialCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4257 |
gtgACCTCTGtctttcttc |
0 | CCAGAGGU | m7b | (m6c->m7b) | -0.061 | -0.226 |
-0.06 |
|
| hsa-miR-4311 |
gtgacctcTCTCTTTCttc |
0 | GAAAGAGA | m8a | Disrupted | 0 | 0.006 |
0.07 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr19:g.45409420C>T | ICGC_1440097 | TCGA-AX-A0J1-01A-11W-A062-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-181a-2-3p |
atTCAGTGGTggccctggc |
0 | ACCACUGA | m8a | (m7b->m8a) | -0.124 | -0.151 |
-0.36 |
|
| hsa-miR-4252 |
attCAGTGGCggccctggc |
0 | GGCCACUG | m7b | (m7b->m6c) | -0.494 | -0.314 |
1.87 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr19:g.45409460G>A | ICGC_1440098 | TCGA-AP-A0LE-01A-11D-A127-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1302 |
tctTGTCCCAgcctgtggg |
0 | UUGGGACA | m7b | (m6c->m7b) | no TS | -0.124 |
-0.14 |
|
| hsa-miR-4298 |
tctTGTCCCAGcctgtggg |
0 | CUGGGACA | m8a | Created | no TS | -0.152 |
-0.39 |
|
| hsa-miR-4438 |
tcttgtcccAGCCTGTGgg |
0 | CACAGGCU | m8a | (m7a->m8a) | no TS | -0.083 |
0.15 |
|
| hsa-miR-4505 |
tcttgtCCCAGCCTgtggg |
0 | AGGCUGGG | m8a | Created | -0.377 | -0.6 |
-0.33 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr19:g.45409554G>C | COSN8973610 | AOCS-166-1-2 | [ovary][NS][other][neoplasm] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-4726-5p |
cttctggTGGCCCaggtgg |
6 |
AGGGCCAG | m6b | Disrupted | -0.155000 | no TS | No effect |
| hsa-miR-486-3p |
cttctggTGCCCCaggtgg |
0 | CGGGGCAG | m6b | Created | no TS | -0.148000 | No effect |
| hsa-miR-593-5p |
cttcTGGTGCCccaggtgg |
0 | AGGCACCA | m7b | Created | no TS | -0.182000 |
-0.130000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 45407787 | rs193096276 | A | A |
hsa-miR-3652 hsa-miR-4430 hsa-miR-4505 hsa-miR-5693 hsa-miR-5787 hsa-miR-6842-3p |
0 |
CCAGCCActgcgc CCAGCCActgcgc CCAGCCActgcgc ccaGCCACTGcgc CCAGCCActgcgc CCAGCCActgcgc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.08 -0.073 -0.072 -0.091 -0.068 -0.137 |
| 45408916 | rs200618543 | C | C |
hsa-miR-4252 hsa-miR-505-5p hsa-miR-6880-5p |
2 7 5 |
CAGTGGCtccacc cagTGGCTCCAcc cagtggCTCCACC |
Disrupted Disrupted Disrupted |
N N N |
-0.075 -0.192 -0.091 |
| 45408923 | rs143443617 | C | C |
hsa-miR-6894-5p hsa-miR-7154-3p hsa-miR-765 hsa-miR-766-5p |
2 2 2 2 |
ctTCCTCCAgtgg ctTCCTCCAgtgg ctTCCTCCAgtgg cTTCCTCCAgtgg |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.037 -0.031 -0.014 -0.065 |
| T |
hsa-miR-1252-5p hsa-miR-181a-2-3p |
2 2 |
cTTCCTTCAgtgg cttcctTCAGTGG |
Created Created |
N N |
0.021 -0.05 |
|||
| 45409061 | rs150941977 | C | C |
hsa-miR-566 hsa-miR-652-3p hsa-miR-668-5p hsa-miR-6789-3p hsa-miR-7153-3p |
1 1 1 1 1 |
gAGGCGCCAtggt gagGCGCCATggt GAGGCGCcatggt gaGGCGCCAtggt gaggcgCCATGGT |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.409 -0.159 -0.263 -0.189 0.014 |
| T |
hsa-miR-6786-3p |
1 |
gaGGCGTCAtggt |
Created |
N |
-0.175 |
|||
| 45409066 | rs140755881 | A | A |
hsa-miR-421 hsa-miR-4709-5p hsa-miR-566 hsa-miR-668-5p |
2 2 1 1 |
CTGTTGAggcgcc CTGTTGAggcgcc ctgttgAGGCGCC ctgttGAGGCGCc |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
0.071 0.03 -0.215 -0.263 |
| G |
hsa-miR-5699-5p hsa-miR-6789-3p hsa-miR-6793-3p |
2 1 2 |
ctgTTGGGGCgcc ctgttgGGGCGCC ctGTTGGGGcgcc |
Created Created Created |
N N N |
-0.109 -0.265 -0.066 |
|||
| 45409176 | rs199559014 | A | A |
hsa-miR-4257 hsa-miR-541-3p hsa-miR-6134 hsa-miR-654-5p hsa-miR-6769a-5p hsa-miR-6769b-5p hsa-miR-92a-2-5p |
16 1 5 1 1 1 1 |
cccaccACCTCTG CCCACCAcctctg cccaCCACCTCtg CCCACCAcctctg CCCACCAcctctg CCCACCAcctctg CCCACCAcctctg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.061 -0.091 -0.106 -0.091 -0.097 -0.097 -0.173 |
| G |
hsa-miR-6087 hsa-miR-6786-5p |
5 1 |
cccaCCGCCTCtg CCCACCGcctctg |
Created Created |
N N |
-0.212 -0.171 |
|||
| 45409419 | rs35448603 | G | G |
hsa-miR-3918 |
1 |
agtggcGGCCCTG |
Disrupted |
N |
-0.146 |
| A |
hsa-miR-4252 hsa-miR-4446-3p hsa-miR-6829-5p |
1 1 1 |
AGTGGCAgccctg agtggCAGCCCTg agtgGCAGCCCtg |
Created Created Created |
N N N |
-0.186 -0.136 -0.198 |
|||
| 45409420 | rs199556175 | C | C |
hsa-miR-4252 |
2 |
CAGTGGCggccct |
Disrupted |
N |
-0.18 |
| G |
hsa-miR-296-5p hsa-miR-4286 hsa-miR-7160-3p |
1 1 1 |
cagtgGGGGCCCt cAGTGGGGgccct cagtggGGGCCCT |
Created Created Created |
N N N |
-0.269 -0.102 -0.188 |