SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001040458
Gene Symbol: ERAP1
Description: Homo sapiens endoplasmic reticulum aminopeptidase 1 (ERAP1), transcript variant 2, mRNA.
Gene Location: chr5(-):96110187-96143892
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.96774920T>G COSN5080862 HX34T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5591-3p attgatgATGGGTAcgaaa
 0 AUACCCAU m7b Created no TS -0.136000 -8.280000


Mutation Mutation ID Sample Name Cancer Type
chr5:g.96774922A>G COSN1321362 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr5:g.96775399C>G COSN4853412 tumor_4112512 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-520d-5p ttacaaTTTGTAactaact
 0 CUACAAAG m6b Created no TS 0.082000 -0.410000
hsa-miR-524-5p ttacaaTTTGTAactaact
 0 CUACAAAG m6b Created no TS 0.082000 -0.120000
hsa-miR-5680 ttacaATTTCTaactaact
 0 GAGAAAUG m6b Disrupted 0.081000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.96776098C>T COSN6587614 ICGC_MB86 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4462 ttaagcacCCGTGTCcaaa
 0 UGACACGG m7b Disrupted -0.249000 no TS 2.310000
hsa-miR-552 ttaagCACCTGTgtccaaa
 0 AACAGGUG m7b Created no TS -0.164000 -0.840000
hsa-miR-602 ttaagcaCCCGTGTCcaaa
 0 GACACGGG m8a Disrupted -0.293000 no TS 2.310000
hsa-miR-764 ttaaGCACCTGtgtccaaa
 7
 GCAGGUGC m7b Created -0.133000 -0.372000 -0.510000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.96776378G>C COSN8892427 B85-0-Tumor [urinary_tract][bladder][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-221-5p ccctTGCCAGGTtcctgtt
 5
 ACCUGGCA m8a Disrupted 0.000000 no TS No effect
hsa-miR-3128 cccTTGCCAGgttcctgtt
 4
 UCUGGCAA m7b (m7b->m6c) 0.000000 no TS No effect
hsa-miR-3688-5p cccTTGCCACgttcctgtt
 3
 AGUGGCAA m7b (m6c->m7b) -0.623000 0.000000 No effect
hsa-miR-3914 cccttgccaGGTTCCTgtt
 9
 AAGGAACC m7b (m7b->m6b) -0.240000 no TS 0.020000
hsa-miR-490-3p cccttgCCAGGTTcctgtt
 3
 CAACCUGG m7b Disrupted -0.170000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.96776379A>C COSN8871193 SNUH_G10_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-221-5p tccctTGCCAGGTtcctgt
 5
 ACCUGGCA m8a Disrupted 0.000000 no TS No effect
hsa-miR-3128 tcccTTGCCAGgttcctgt
 4
 UCUGGCAA m7b Disrupted 0.000000 no TS No effect
hsa-miR-490-3p tcccttgCCAGGTTcctgt
 3
 CAACCUGG m7b Disrupted -0.170000 no TS No effect
hsa-miR-221-5p tccctTGCCAGGTtcctgt
 5
 ACCUGGCA m8a Disrupted 0.000000 no TS No effect
hsa-miR-3128 tcccTTGCCAGgttcctgt
 4
 UCUGGCAA m7b Disrupted 0.000000 no TS No effect
hsa-miR-490-3p tcccttgCCAGGTTcctgt
 3
 CAACCUGG m7b Disrupted -0.170000 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
96776097 rs148692674 - - hsa-miR-4462
hsa-miR-602
0 agcacCCGTGTCcaa
agcaCCCGTGTccaa
 Unknown
Unknown
N
N
 -0.249
-0.293
CA hsa-miR-342-5p
hsa-miR-4651
hsa-miR-4664-5p
hsa-miR-608
hsa-miR-6737-5p
hsa-miR-6747-5p
hsa-miR-6757-3p
hsa-miR-6812-5p
hsa-miR-6819-5p
hsa-miR-7155-5p
0 aGCACCCCAgtgtccaa
agCACCCCAgtgtccaa
aGCACCCCAgtgtccaa
agCACCCCAgtgtccaa
agCACCCCAgtgtccaa
agCACCCCAgtgtccaa
agcaccCCAGTGTccaa
agCACCCCAgtgtccaa
agCACCCCAgtgtccaa
agcACCCCAGtgtccaa
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
N
N
N
 -0.484
-0.17
-0.495
-0.166
-0.208
-0.194
-0.149
-0.171
-0.208
-0.184
96776098 rs113677417 C C hsa-miR-4462
hsa-miR-602
3
2
 agcacCCGTGTCc
agcaCCCGTGTcc
 Disrupted
Disrupted
N
N
 -0.249
-0.293
A hsa-miR-3907
hsa-miR-548q
hsa-miR-6757-3p
0 AGCACCAgtgtcc
aGCACCAGtgtcc
agcaCCAGTGTcc
 Created
Created
Created
N
N
N
 -0.166
-0.29
-0.196
96776379 rs1065407 A A hsa-miR-221-5p
hsa-miR-3128
hsa-miR-31-5p
hsa-miR-490-3p
hsa-miR-6809-5p
hsa-miR-8073
5
4
5
3
5
5
 ctTGCCAGGttcc
cTTGCCAGgttcc
CTTGCCAggttcc
cttgCCAGGTTcc
CTTGCCAggttcc
ctTGCCAGGttcc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 No Change
No Change
No Change
-0.17
No Change
No Change

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