SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_182644
Gene Symbol: EPHA3
Description: Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA.
Gene Location: chr3(+):89156673-89449495
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.89399574A>G COSN1283248 HCC8T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130a-5p ttttaaacaAATGTGAtac
 3
 UUCACAUU m7b (m7b->m6c) -0.197000 no TS 0.790000
hsa-miR-23a-3p ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.169000 no TS 0.390000
hsa-miR-23b-3p ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.178000 no TS 0.390000
hsa-miR-23c ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.178000 no TS 0.390000
hsa-miR-130a-5p ttttaaacaAATGTGAtac
 3
 UUCACAUU m7b (m7b->m6c) -0.197000 no TS 0.790000
hsa-miR-23a-3p ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.169000 no TS 0.390000
hsa-miR-23b-3p ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.178000 no TS 0.390000
hsa-miR-23c ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.178000 no TS 0.390000
hsa-miR-130a-5p ttttaaacaAATGTGAtac
 3
 UUCACAUU m7b (m7b->m6c) -0.197000 no TS 0.790000
hsa-miR-23a-3p ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.169000 no TS 0.390000
hsa-miR-23b-3p ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.178000 no TS 0.390000
hsa-miR-23c ttttaaacaAATGTGATac
 3
 AUCACAUU m8a (m8a->m7b) -0.178000 no TS 0.390000
hsa-miR-130a-5p ttttaaacaAATGTGAtac
 0 UUCACAUU m7b (m7b->m6c) -0.197 no TS 0.79
hsa-miR-23a-3p ttttaaacaAATGTGATac
 0 AUCACAUU m8a (m8a->m7b) -0.169 no TS 0.39
hsa-miR-23b-3p ttttaaacaAATGTGATac
 0 AUCACAUU m8a (m8a->m7b) -0.178 no TS 0.39
hsa-miR-23c ttttaaacaAATGTGATac
 0 AUCACAUU m8a (m8a->m7b) -0.178 no TS 0.39

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89399637A>G 9_106177 CRC-9-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7f-2-3p tgtCTGTATAcagtatttg
 7
 CUAUACAG m7b (m7b->m6b) -0.103 no TS 1.18
hsa-miR-1183 tgtctgtaTACAGTatttg
 0 CACUGUAG m6b Disrupted -0.096 no TS 1.64
hsa-miR-1185-1-3p tgtCTGTATAcagtatttg
 7
 AUAUACAG m7b (m7b->m6b) -0.113 no TS 1.14
hsa-miR-1185-2-3p tgtCTGTATAcagtatttg
 7
 AUAUACAG m7b (m7b->m6b) -0.113 no TS 1.14
hsa-miR-217 tgtctgtATGCAGTAtttg
 0 UACUGCAU m8a Created no TS -0.345 -6.02
hsa-miR-4418 tgtctgtaTGCAGTatttg
 0 CACUGCAG m6b Created no TS -0.133 -5.766
hsa-miR-509-3-5p tgtctgtaTGCAGTAtttg
 0 UACUGCAG m7a Created no TS -0.13 -4.54
hsa-miR-509-5p tgtctgtaTGCAGTAtttg
 0 UACUGCAG m7a Created no TS -0.13 -6.01
hsa-miR-5689 tgtcTGTATGCagtatttg
 7
 AGCAUACA m7b Created -0.409 -0.72 -2.4

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89399691C>A 0_147 Prostate cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-153 tcttgTATGCAAatcaaac
 1
 UUGCAUAG m7a Disrupted -0.153 no TS 2.93
hsa-miR-335-3p tcttgtATGAAAAtcaaac
 4
 UUUUUCAU m7b Created no TS -0.055 -0.14
hsa-miR-3680-3p tcttgtATGCAAAtcaaac
 4
 UUUUGCAU m7b Disrupted -0.202 -0.07 0.05
hsa-miR-448 tcttgTATGCAAatcaaac
 1
 UUGCAUAU m7a Disrupted -0.127 no TS 7.56
hsa-miR-485-3p tctTGTATGAaaatcaaac
 1
 GUCAUACA m7b (m6b->m7b) no TS -0.297 -2.01
hsa-miR-539-3p tctTGTATGAaaatcaaac
 1
 AUCAUACA m7b (m6b->m7b) no TS -0.339 -3.1
hsa-miR-5689 tctTGTATGCaaatcaaac
 1
 AGCAUACA m7b (m7b->m6b) -0.409 no TS 1.2

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89399700C>A COSN8369091 tumor_4116738 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4307 caaatcAAACATattctaa
 2
 AAUGUUUU m6b Disrupted -0.030000 no TS -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89399790G>C COSN5545411 RK038_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1324 acacttccaCTGTCTGtca
 3
 CCAGACAG m7b (m6c->m7b) -0.127000 -0.306000 -0.380000
hsa-miR-3190-3p acaCTTCCACtgtctgtca
 0 UGUGGAAG m7b (m6b->m7b) no TS -0.202000 -0.750000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89399815G>A COSN1283250 HCC123T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1299 ataTTCCAGAttcattgcg
 0 UUCUGGAA m7b (m6b->m7b) no TS -0.201000 -6.600000
hsa-miR-490-3p atattCCAGGTTcattgcg
 6
 CAACCUGG m7b Disrupted -0.234000 no TS -0.700000
hsa-miR-619 atatTCCAGGTtcattgcg
 6
 GACCUGGA m7b Disrupted -0.257000 no TS 3.790000
hsa-miR-1299 ataTTCCAGAttcattgcg
 0 UUCUGGAA m7b (m6b->m7b) no TS -0.201 -6.6
hsa-miR-490-3p atattCCAGGTTcattgcg
 6
 CAACCUGG m7b Disrupted -0.234 no TS -0.7
hsa-miR-619 atatTCCAGGTtcattgcg
 6
 GACCUGGA m7b Disrupted -0.257 no TS 3.79

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89399947C>T COSN9895505 C0049T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3616-5p gtgttttatCACTTCATtc
 2
 AUGAAGUG m8a (m8a->m7b) -0.209000 no TS 0.820000
hsa-miR-4795-5p gtgttttatCACTTCattc
 2
 AGAAGUGG m6b Disrupted -0.117000 no TS 0.050000
hsa-miR-548ao-5p gtgttttaTTACTTCattc
 0 AGAAGUAA m7b Created no TS -0.269000 0.400000
hsa-miR-548ax gtgttttaTTACTTCattc
 0 AGAAGUAA m7b Created no TS -0.269000 -0.070000
hsa-miR-573 gtgttttatCACTTCAttc
 2
 CUGAAGUG m7b (m7b->m6c) -0.219000 no TS 1.370000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89400066T>G COSN9895506 C0027T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181a-5p caaaTGAATGTTcttcata
 0 AACAUUCA m8a Created no TS -0.166000 -4.250000
hsa-miR-181b-5p caaaTGAATGTTcttcata
 0 AACAUUCA m8a Created no TS -0.166000 -4.280000
hsa-miR-181c-5p caaaTGAATGTTcttcata
 0 AACAUUCA m8a Created no TS -0.157000 -3.370000
hsa-miR-181d caaaTGAATGTTcttcata
 0 AACAUUCA m8a Created no TS -0.176000 -4.280000
hsa-miR-4262 caaaTGAATGTtcttcata
 0 GACAUUCA m7b Created no TS -0.139000 -2.510000
hsa-miR-4511 caaatgaatGTTCTTCata
 0 GAAGAACU m7a (m6b->m7a) NA NA -2.290000
hsa-miR-4760-3p caaATGAATTTtcttcata
 2
 AAAUUCAU m8a Disrupted -0.119000 no TS 3.160000
hsa-miR-543 caaatGAATGTTcttcata
 0 AAACAUUC m7b Created no TS -0.144000 -2.300000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89400149G>T COSN15229805 LP6005334-DNA_E03 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-382-3p ataaAATGATTagaagtta
 0 AAUCAUUC m7a Created NA NA -5.070000
hsa-miR-576-5p ataaaatgATTAGAAgtta
 0 AUUCUAAU m7b Created no TS -0.076000 -0.060000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89400217G>A ICGC_72AC9088-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3120-5p ttttgAGACAGagtcttgc
 0 CCUGUCUG m6b Created no TS -0.115 No effect
hsa-miR-340-3p ttttGAGACGGAgtcttgc
 1
 UCCGUCUC m8a Disrupted -0.495 no TS 5.241
hsa-miR-3664-5p ttttgagACAGAGTcttgc
 0 AACUCUGU m7b Created no TS -0.161 -0.21
hsa-miR-4522 ttttgagaCAGAGTCttgc
 0 UGACUCUG m7b Created no TS -0.219 -0.06

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89400304C>T COSN6575897 ICGC_MB78 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3622b-5p ctggcttCATGCCattctc
 0 AGGCAUGG m6b Created no TS -0.132000 -7.980000
hsa-miR-5197-5p ctggcttcaTGCCATTctc
 0 CAAUGGCA m7b (m6c->m7b) no TS -0.115000 -0.270000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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