SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005233
Gene Symbol: EPHA3
Description: Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA.
Gene Location: chr3(+):89156673-89531284
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.89479529G>C COSN1283268 BN23T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-198 ctTCTGGACCgaagtggtg
 0 GGUCCAGA m8a (m7a->m8a) -0.228000 -0.228000 No effect
hsa-miR-4746-5p cttctGGACCGaagtggtg
 0 CCGGUCCC m6b Created no TS -0.265000 -8.860000
hsa-miR-198 ctTCTGGACCgaagtggtg
 0 GGUCCAGA m8a (m7a->m8a) -0.228000 -0.228000 No effect
hsa-miR-4746-5p cttctGGACCGaagtggtg
 0 CCGGUCCC m6b Created no TS -0.265000 -8.860000
hsa-miR-198 ctTCTGGACCgaagtggtg
 0 GGUCCAGA m8a (m7a->m8a) -0.228 -0.228 No effect
hsa-miR-4746-5p cttctGGACCGaagtggtg
 0 CCGGUCCC m6b Created no TS -0.265 -8.86


Mutation Mutation ID Sample Name Cancer Type
chr3:g.89479530G>T COSN1283269 BN23T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.89480017T>A COSN1971587 RK075_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-577 tctctTTTATCTgtttaaa
 12
 UAGAUAAA m7b Disrupted -0.050000 no TS No effect
hsa-miR-577 tctctTTTATCTgtttaaa
 12
 UAGAUAAA m7b Disrupted -0.05 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89480453A>C COSN9578138 AOCS-142-3-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1262 ggatttTCACCCAgataac
 0 AUGGGUGA m7b Created no TS -0.140000 -0.120000
hsa-miR-29b-1-5p ggattttcAACCAGataac
 0 GCUGGUUU m6b Disrupted -0.048000 no TS 0.010000
hsa-miR-4701-3p ggatttTCACCCAgataac
 0 AUGGGUGA m7b Created no TS -0.158000 -0.010000
hsa-miR-563 ggatttTCAACCagataac
 0 AGGUUGAC m6b Disrupted -0.080000 no TS 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89480620->A ICGC_ssm_v2_74207 HX13T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2681-5p tgcatgaGTAAAAaaaaaa
 1
 GUUUUACC m6b Disrupted 0.094000 0.092000 -0.100000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89480870G>T COSN8489689 2296_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1297 gaattTACTTGAcataaca
 0 UUCAAGUA m7b Created no TS -0.056000 -3.990000
hsa-miR-145-5p gaatttACTGGACataaca
 0 GUCCAGUU m7a Disrupted NA NA 6.500000
hsa-miR-198 gaatttaCTGGACataaca
 0 GGUCCAGA m6b Disrupted -0.228000 -0.148000 5.020000
hsa-miR-26a-5p gaattTACTTGAcataaca
 0 UUCAAGUA m7b Created no TS -0.037000 -2.230000
hsa-miR-26b-5p gaattTACTTGAcataaca
 0 UUCAAGUA m7b Created no TS -0.056000 -3.110000
hsa-miR-4465 gaattTACTTGAcataaca
 0 CUCAAGUA m7b Created no TS -0.019000 -0.010000
hsa-miR-545-5p gaaTTTACTGgacataaca
 2
 UCAGUAAA m7b (m7b->m6b) 0.030000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89480873C>G COSN8489690 J30_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-145-5p tttACTGGACataacattt
 0 GUCCAGUU m7a (m7a->m6a) NA NA 1.790000
hsa-miR-198 tttaCTGGACataacattt
 0 GGUCCAGA m6b Disrupted -0.228000 -0.148000 5.020000
hsa-miR-3925-3p tttACTGGAGataacattt
 10
 ACUCCAGU m7b (m6b->m7b) -0.267000 -0.457000 -1.320000
hsa-miR-766-3p tttaCTGGAGataacattt
 10
 ACUCCAGC m6b Created -0.141000 -0.187000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481033A>T COSN1971588 RK049_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4661-5p tatctAGCTAGTaatatat
 2
 AACUAGCU m7b Disrupted -0.245000 no TS 0.090000
hsa-miR-4661-5p tatctAGCTAGTaatatat
 2
 AACUAGCU m7b Disrupted -0.245 no TS 0.09

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481126T>C COSN5545437 RK156_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4800-3p tcactagaACGGATaaaat
 0 CAUCCGUC m6b Created no TS -0.157000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481173G>A COSN7716447 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3591-5p aaatggaACACTAAtgaaa
 4
 UUUAGUGU m7b Created -0.068000 -0.121000 No effect
hsa-miR-4255 aaatgGAACACTaatgaaa
 0 CAGUGUUC m7b Created no TS -0.131000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481197G>A COSN8369101 tumor_4188900 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-450a-5p cttacaaTCGCAAAtcaaa
 0 UUUUGCGA m7b Disrupted -0.186000 no TS 4.800000
hsa-miR-508-3p ctTACAATCAcaaatcaaa
 4
 UGAUUGUA m8a (m7a->m8a) -0.034000 -0.093000 -0.430000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481244A>T EPHA3_E17_UTR_3 SJHYPO026_D Hypodiploid_ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1264 tagtgtaatAAGACTTaga
 0 CAAGUCUU m7b (m7b->m6c) -0.206 -0.135 4.26
hsa-miR-4735-5p tagtgtAATTAGacttaga
 0 CCUAAUUU m6b Created no TS 0.085 -0.17
hsa-miR-556-3p tagtGTAATAagacttaga
 10
 AUAUUACC m6b Disrupted 0.05 no TS 0.13


Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481305T>A COSN1971589 RK189_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481437T>A COSN14607523 8012342 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481606C>G COSN6784001 RK077_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4724-5p tctatTTCAGTTattttgg
 3
 AACUGAAC m7a Created -0.059000 -0.059000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481636T>C COSN1971590 RK050_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-138-1-3p atctgaAAGTAGaggttgt
 0 GCUACUUC m6b Disrupted -0.026000 no TS 0.330000
hsa-miR-3160-5p atctGAAAGCagaggttgt
 0 GGCUUUCU m6b Created no TS -0.032000 -0.030000
hsa-miR-138-1-3p atctgaAAGTAGaggttgt
 0 GCUACUUC m6b Disrupted -0.026000 no TS 0.330000
hsa-miR-3160-5p atctGAAAGCagaggttgt
 0 GGCUUUCU m6b Created no TS -0.032000 -0.030000
hsa-miR-138-1-3p atctgaAAGTAGaggttgt
 0 GCUACUUC m6b Disrupted -0.026 no TS 0.33
hsa-miR-3160-5p atctGAAAGCagaggttgt
 0 GGCUUUCU m6b Created no TS -0.032 -0.03

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481730C>T COSN14953830 LP6005409-DNA_E01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-2-3p taccCTGTACAtatgtaaa
 8
 CUGUACAG m7b Disrupted -0.238000 -0.095000 No effect
hsa-let-7f-2-3p taccCTGTATAtatgtaaa
 13
 CUAUACAG m7b Created -0.031000 -0.123000 No effect
hsa-let-7g-3p taccCTGTACAtatgtaaa
 8
 CUGUACAG m7b Disrupted -0.239000 -0.105000 0.050000
hsa-miR-1185-1-3p taccCTGTATATatgtaaa
 13
 AUAUACAG m8a Created -0.031000 -0.142000 -4.100000
hsa-miR-1185-2-3p taccCTGTATATatgtaaa
 13
 AUAUACAG m8a Created -0.031000 -0.142000 -4.090000
hsa-miR-5011-5p taccctgTATATATgtaaa
 8
 UAUAUAUA m7b Created 0.109000 0.153000 -3.310000
hsa-miR-5580-3p taccctgtaCATATGTaaa
 18
 CACAUAUG m7b (m7b->m6c) -0.156000 0.015000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.89481961G>A COSN7768423 PCSI_0048_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7a-3p tcaagccaTGTATAaatgt
 13
 CUAUACAA m6b Disrupted -0.035000 -0.012000 No effect
hsa-let-7b-3p tcaagccaTGTATAaatgt
 13
 CUAUACAA m6b Disrupted -0.025000 -0.002000 No effect
hsa-let-7f-1-3p tcaagccaTGTATAaatgt
 13
 CUAUACAA m6b Disrupted -0.004000 0.026000 No effect
hsa-let-7f-2-3p tcaagccaTGTATAaatgt
 13
 CUAUACAG m6b Disrupted -0.031000 no TS No effect
hsa-miR-1185-1-3p tcaagccaTGTATAaatgt
 13
 AUAUACAG m6b Disrupted -0.031000 no TS No effect
hsa-miR-1185-2-3p tcaagccaTGTATAaatgt
 13
 AUAUACAG m6b Disrupted -0.031000 no TS No effect
hsa-miR-135a-5p tcAAGCCATAtataaatgt
 13
 UAUGGCUU m8a (m7a->m8a) -0.206000 -0.373000 No effect
hsa-miR-135b-5p tcAAGCCATAtataaatgt
 13
 UAUGGCUU m8a (m7a->m8a) -0.206000 -0.373000 No effect
hsa-miR-4666a-5p tcaagcCATGTATaaatgt
 14
 AUACAUGU m7a Disrupted -0.065000 -0.065000 0.010000
hsa-miR-4789-5p tcaagccaTGTATAaatgt
 13
 GUAUACAC m6b Disrupted -0.030000 no TS No effect
hsa-miR-5011-5p tcaagccATATATAaatgt
 8
 UAUAUAUA m7a Created 0.109000 0.150000 -0.060000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
89480510 rs186325629 G G hsa-miR-4509
hsa-miR-6837-3p
2
4
 CCTTTAGtgaagg
cctttAGTGAAGg
 Disrupted
Disrupted
N
N
 0.004
0.006
C hsa-miR-222-5p
hsa-miR-545-5p
2
2
 ccttTACTGAAgg
ccTTTACTGAagg
 Created
Created
N
N
 0.043
0.106
89480554 rs181612461 A A hsa-miR-3925-3p
hsa-miR-4768-5p
hsa-miR-6833-3p
hsa-miR-6845-3p
hsa-miR-6873-3p
hsa-miR-766-3p
hsa-miR-942-5p
2
2
2
2
2
2
1
 CTGGAGAgaagtg
ctgGAGAGAAgtg
ctgGAGAGAAgtg
ctGGAGAGAagtg
ctgGAGAGAAgtg
CTGGAGAgaagtg
ctggAGAGAAGtg
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.077
0.06
0.069
-0.021
0.009
-0.001
0.028
G hsa-miR-1470
hsa-miR-4667-3p
hsa-miR-642a-5p
2
2
2
 ctGGAGGGAagtg
ctGGAGGGAagtg
ctgGAGGGAAgtg
 Created
Created
Created
N
N
N
 -0.083
-0.059
-0.045
89480620 rs74438214 A A hsa-miR-2681-5p
1
 atgaGTAAAAAaa
 Disrupted
N
 0.094
T hsa-miR-4764-3p
hsa-miR-552-5p
hsa-miR-6750-3p
1
1
1
 atGAGTTAAaaaa
atgaGTTAAAAaa
aTGAGTTAaaaaa
 Created
Created
Created
N
N
N
 -0.005
0.088
0.004
89481197 rs73139147 A G hsa-miR-450a-5p
0 acaaTCGCAAAtc
 Created
N
 -0.186
A hsa-miR-219a-5p
hsa-miR-4445-5p
hsa-miR-4782-3p
hsa-miR-508-3p
hsa-miR-6766-3p
hsa-miR-758-3p
hsa-miR-8070
0 ACAATCAcaaatc
ACAATCAcaaatc
ACAATCAcaaatc
ACAATCAcaaatc
ACAATCAcaaatc
acaaTCACAAAtc
acAATCACAAatc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.011
-0.007
-0.011
-0.059
-0.011
-0.011
-0.097
89481806 rs73139148 G G hsa-miR-486-5p
hsa-miR-584-3p
hsa-miR-7152-5p
10
3
6
 tGTACAGGAactg
tgtacaGGAACTG
tgtACAGGAActg
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.385
-0.212
-0.14
A hsa-let-7a-2-3p
hsa-let-7c-3p
hsa-let-7g-3p
hsa-miR-4277
hsa-miR-493-5p
hsa-miR-5584-3p
hsa-miR-578
hsa-miR-643
13
13
13
3
13
6
6
10
 TGTACAAgaactg
TGTACAAgaactg
TGTACAAgaactg
tgtacaAGAACTG
TGTACAAgaactg
tgtacAAGAACTg
tgtACAAGAActg
tgTACAAGAactg
 Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
 -0.043
-0.105
-0.049
-0.17
-0.05
-0.043
-0.084
-0.073
89481898 rs189642147 C C hsa-miR-379-3p
hsa-miR-380-3p
hsa-miR-411-3p
hsa-miR-4495
5
5
5
5
 gatTTACATAtat
gatTTACATAtat
gatTTACATAtat
gaTTTACATAtat
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.072
-0.063
-0.072
-0.226
T hsa-miR-190a-3p
hsa-miR-410-3p
hsa-miR-5011-5p
11
5
6
 gatttATATATAt
gatTTATATAtat
gattTATATATAt
 Created
Created
Created
N
N
N
 -0.111
-0.012
-0.255

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