SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001424
Gene Symbol: EMP2
Description: Homo sapiens epithelial membrane protein 2 (EMP2), mRNA.
Gene Location: chr16(-):10622278-10674539
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr16:g.10529330C>A COSN7297431 8034061 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4666a-5p gcttcttACATGTAgatag
 0 AUACAUGU m7b Created no TS -0.056000 -0.140000
hsa-miR-552 gcttcttACCTGTagatag
 3
 AACAGGUG m6b Disrupted -0.020000 0.020000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10529691T>C COSN4904777 CPCG_0183_Pr_P_P2 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-149-3p cctcagCCTCCCaaagtgc
 0 AGGGAGGG m6b Created -0.163000 -0.187000 No effect
hsa-miR-30b-3p cctcagCCTCCCAaagtgc
 1
 CUGGGAGG m7b Created 0.041000 0.010000 -0.060000
hsa-miR-30c-1-3p cctcagcCTCCCAaagtgc
 1
 CUGGGAGA m6b Created 0.033000 0.056000 No effect
hsa-miR-30c-2-3p cctcagcCTCCCAaagtgc
 1
 CUGGGAGA m6b Created 0.033000 0.053000 No effect
hsa-miR-3122 cctcagccTCCCAAagtgc
 0 GUUGGGAC m6b Created no TS 0.053000 -0.050000
hsa-miR-3202 cctcagCCTTCCAaagtgc
 2
 UGGAAGGG m7a Disrupted 0.020000 no TS No effect
hsa-miR-3689a-3p cctcagCCTCCCAaagtgc
 1
 CUGGGAGG m7b Created 0.037000 0.006000 -1.520000
hsa-miR-3689b-3p cctcagCCTCCCAaagtgc
 1
 CUGGGAGG m7b Created 0.037000 0.006000 -1.230000
hsa-miR-3689c cctcagCCTCCCAaagtgc
 1
 CUGGGAGG m7b Created 0.037000 0.006000 -1.230000
hsa-miR-3929 ccTCAGCCTCccaaagtgc
 2
 GAGGCUGA m8a (m7b->m8a) 0.163000 0.190000 -0.140000
hsa-miR-4419b ccTCAGCCTCccaaagtgc
 2
 GAGGCUGA m8a (m7b->m8a) 0.135000 0.162000 No effect
hsa-miR-4478 ccTCAGCCTCccaaagtgc
 2
 GAGGCUGA m8a (m7b->m8a) 0.098000 0.125000 -0.060000
hsa-miR-4533 cctcagCCTTCCAaagtgc
 2
 UGGAAGGA m7a Disrupted 0.037000 0.020000 0.590000
hsa-miR-4728-5p cctcagCCTCCCAaagtgc
 0 UGGGAGGG m7a Created -0.135000 -0.152000 No effect
hsa-miR-485-5p cctCAGCCTCccaaagtgc
 2
 AGAGGCUG m7b (m6c->m7b) -0.021000 -0.018000 No effect
hsa-miR-149-3p cctcagCCTCCCaaagtgc
 0 AGGGAGGG m6b Created -0.163 -0.187 No effect
hsa-miR-30b-3p cctcagCCTCCCAaagtgc
 0 CUGGGAGG m7b Created 0.041 0.01 -0.06
hsa-miR-30c-1-3p cctcagcCTCCCAaagtgc
 0 CUGGGAGA m6b Created 0.033 0.056 No effect
hsa-miR-30c-2-3p cctcagcCTCCCAaagtgc
 0 CUGGGAGA m6b Created 0.033 0.053 No effect
hsa-miR-3122 cctcagccTCCCAAagtgc
 0 GUUGGGAC m6b Created no TS 0.053 -0.05
hsa-miR-3202 cctcagCCTTCCAaagtgc
 0 UGGAAGGG m7a Disrupted 0.02 no TS No effect
hsa-miR-3689a-3p cctcagCCTCCCAaagtgc
 0 CUGGGAGG m7b Created 0.037 0.006 -1.52
hsa-miR-3689b-3p cctcagCCTCCCAaagtgc
 0 CUGGGAGG m7b Created 0.037 0.006 -1.23
hsa-miR-3689c cctcagCCTCCCAaagtgc
 0 CUGGGAGG m7b Created 0.037 0.006 -1.23
hsa-miR-3929 ccTCAGCCTCccaaagtgc
 0 GAGGCUGA m8a (m7b->m8a) 0.163 0.19 -0.14
hsa-miR-4419b ccTCAGCCTCccaaagtgc
 0 GAGGCUGA m8a (m7b->m8a) 0.135 0.162 No effect
hsa-miR-4478 ccTCAGCCTCccaaagtgc
 0 GAGGCUGA m8a (m7b->m8a) 0.098 0.125 -0.06
hsa-miR-4533 cctcagCCTTCCAaagtgc
 0 UGGAAGGA m7a Disrupted 0.037 0.02 0.59
hsa-miR-4728-5p cctcagCCTCCCAaagtgc
 0 UGGGAGGG m7a Created -0.135 -0.152 No effect
hsa-miR-485-5p cctCAGCCTCccaaagtgc
 0 AGAGGCUG m7b (m6c->m7b) -0.021 -0.018 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10529717C>T COSN4764404 tumor_4194891 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-377-5p actccCAACCTCaggtgat
 1
 AGAGGUUG m7b Disrupted 0.150000 0.089000 No effect
hsa-miR-382-5p actccCAACTTCaggtgat
 0 GAAGUUGU m7a Created NA NA -0.010000
hsa-miR-4259 actCCCAACTtcaggtgat
 0 CAGUUGGG m7b (m6c->m7b) no TS -0.022000 -0.200000
hsa-miR-544b actcccaaCCTCAGGTgat
 2
 ACCUGAGG m8a Disrupted -0.021000 no TS 1.140000
hsa-miR-92a-1-5p actCCCAACCTcaggtgat
 1
 AGGUUGGG m8a Disrupted -0.067000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10529848A>G COSN8484799 AOCS-116-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-34b-3p ctgggttcaAGTGATTctc
 2
 CAAUCACU m7b (m7b->m6b) 0.101000 no TS 0.010000
hsa-miR-3614-5p ctgggttCAAGTGattctc
 2
 CCACUUGG m6b Disrupted -0.159000 -0.233000 0.010000
hsa-miR-3622a-3p ctgggtTCAGGTGAttctc
 2
 UCACCUGA m8a Created 0.038000 0.008000 No effect
hsa-miR-3622b-3p ctgggtTCAGGTGAttctc
 2
 UCACCUGA m8a Created 0.030000 0.021000 -0.070000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10530725G>T COSN8590697 J36_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4681 ggggTTCCCGTgctgcttg
 0 AACGGGAA m7b Disrupted 0.010000 no TS No effect


Mutation Mutation ID Sample Name Cancer Type
chr16:g.10530879A>C 10_4871 6408 Breast cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr16:g.10530933G>A COSN8484800 AOCS-060-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3622a-5p gctttacgCGTGCCTatta
 2
 CAGGCACG m7b Disrupted -0.119000 no TS 0.010000
hsa-miR-3622b-5p gctttacgCATGCCTatta
 1
 AGGCAUGG m7a Created -0.047000 -0.047000 0.010000
hsa-miR-4423-3p gctttacgcGTGCCTATta
 2
 AUAGGCAC m8a (m8a->m7a) -0.075000 no TS 0.860000
hsa-miR-564 gctttacgCGTGCCTatta
 1
 AGGCACGG m7a Disrupted -0.322000 -0.322000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10531607T>C ICGC_AE6AE200-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4438 ggctcatGCCTGTaatccc
 0 CACAGGCU m6b Created -0.111 -0.107 No effect
hsa-miR-4514 ggctcaTGCCTGTaatccc
 0 ACAGGCAG m7a Created NA NA No effect
hsa-miR-5095 ggctcatGCCTGTAAtccc
 0 UUACAGGC m8a Created -0.002 -0.076 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10531789T>G cosmic_v64_1629909 Lymphoma Non-Hodgkin
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4456 catCCACCAGtcattcatt
 0 CCUGGUGG m7b (m6c->m7b) no TS -0.126 -0.19
hsa-miR-4790-3p catccACCATTCAttcatt
 0 UGAAUGGU m8a Disrupted -0.006 0.046 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10531798C>A COSN6079428 RK181_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1193 cagaggacCCATCCaccat
 2
 GGGAUGGU m6b Disrupted -0.050000 -0.007000 0.030000
hsa-miR-133a cagaGGACCAAtccaccat
 15
 UUUGGUCC m7b Created -0.280000 -0.337000 -0.040000
hsa-miR-133b cagaGGACCAAtccaccat
 15
 UUUGGUCC m7b Created -0.280000 -0.346000 -0.200000
hsa-miR-3691-5p cagaggaccCATCCACcat
 5
 AGUGGAUG m7b (m7b->m6b) -0.240000 -0.217000 0.080000
hsa-miR-432-3p cagaggacCCATCCAccat
 6
 CUGGAUGG m7b Disrupted -0.158000 -0.102000 0.770000
hsa-miR-509-3p cagaggACCAATCcaccat
 0 UGAUUGGU m7b Created no TS -0.028000 -4.400000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10531899C>T COSN8484801 AOCS-113-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1252 gggtacagcTTCCTTCcca
 2
 AGAAGGAA m7b (m6b->m7b) 0.081000 0.179000 No effect
hsa-miR-3173-3p gggtacagCCTCCTTccca
 2
 AAAGGAGG m7b Disrupted 0.029000 no TS -0.030000
hsa-miR-4695-5p gggtacaGCCTCCTtccca
 2
 CAGGAGGC m7b Disrupted -0.072000 -0.003000 No effect
hsa-miR-4718 ggGTACAGCTtccttccca
 0 AGCUGUAC m8a (m7b->m8a) -0.024000 -0.051000 -0.210000
hsa-miR-485-5p gggtaCAGCCTCcttccca
 2
 AGAGGCUG m7b Disrupted -0.021000 0.024000 0.410000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10531968T>G COSN5404406 RK102_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3171 ctgtcTACATCTagggccc
 1
 AGAUGUAU m7a Disrupted -0.012000 -0.012000 No effect
hsa-miR-3668 ctgTCTACATctagggccc
 2
 AAUGUAGA m7b (m7b->m6c) 0.059000 no TS No effect
hsa-miR-4718 ctgtcTACAGCTagggccc
 0 AGCUGUAC m7a Created -0.024000 -0.024000 -0.680000
hsa-miR-576-3p ctgtctACATCTagggccc
 2
 AAGAUGUG m6b Disrupted -0.018000 -0.071000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10532113C>T 9_52378 CRC-5-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3912 cttcagATGCGTTgaagtt
 3
 UAACGCAU m7b Disrupted -0.071 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10532686G>T COSN8179700 PCSI_0048_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-205-5p actATGAAGGctggtattc
 7
 UCCUUCAU m7b (m7b->m6c) -0.200000 -0.058000 0.020000
hsa-miR-3614-3p actatGAAGGCTggtattc
 0 UAGCCUUC m7b Disrupted -0.238000 no TS 0.490000
hsa-miR-499b-5p actatgAAGTCTGgtattc
 2
 ACAGACUU m7b Created 0.059000 -0.084000 -0.010000
hsa-miR-634 actatgaagGCTGGTattc
 4
 AACCAGCA m6b Disrupted -0.186000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.10532758G>A COSN6413425 HCC110T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
10528536 rs148724239 A A hsa-miR-576-3p
2
 gatgACATCTAgg
 Disrupted
N
 -0.071
10529253 rs9931575 A A hsa-miR-3618
hsa-miR-432-3p
hsa-miR-4764-5p
hsa-miR-934
1
6
8
1
 GTAGACAtccaag
gtagaCATCCAAg
gtagACATCCAag
GTAGACAtccaag
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.099
-0.052
-0.083
-0.079
T hsa-miR-6079
6
 gtagaCTTCCAAg
 Created
N
 -0.037
10529447 rs12996 C C hsa-miR-3165
hsa-miR-3691-5p
hsa-miR-552-3p
2
2
3
 cATCCACCtgtgc
CATCCACctgtgc
catcCACCTGTgc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.047
-0.063
-0.017
T hsa-miR-3134
hsa-miR-5683
2
3
 cATCCATCtgtgc
catcCATCTGTgc
 Created
Created
N
N
 -0.019
0.035
10529447 rs199818876 - CCAC hsa-miR-3165
hsa-miR-3691-5p
hsa-miR-552-3p
2
2
3
 ccacATCCACCtgtgccat
ccaCATCCACctgtgccat
ccacatcCACCTGTgccat
 Unknown
Unknown
Unknown
N
N
N
 -0.047
-0.063
-0.017
- hsa-miR-183-5p
hsa-miR-5683
3
2
 ccacatctGTGCCAT
ccaCATCTGTgccat
 Unknown
Unknown
N
N
 -0.017
0.019
10530934 rs138204552 C C hsa-miR-3622a-5p
2
 tttacgCGTGCCT
 Disrupted
N
 -0.067
10531973 rs148033494 C C hsa-miR-3668
hsa-miR-4524b-3p
2
2
 agctgTCTACATc
agCTGTCTAcatc
 Disrupted
Disrupted
N
N
 0.059
0.013
A hsa-let-7f-2-3p
hsa-miR-1185-1-3p
hsa-miR-1185-2-3p
hsa-miR-3171
2
2
2
2
 agCTGTATAcatc
agCTGTATAcatc
agCTGTATAcatc
agctgtATACATC
 Created
Created
Created
Created
N
N
N
N
 0.06
0.079
0.079
-0.03
10532652 rs112374555 T T hsa-miR-3672
hsa-miR-653-5p
hsa-miR-6864-3p
hsa-miR-873-3p
3
2
3
7
 aaAGTCTCAAcaa
aaagtcTCAACAA
aaAGTCTCAAcaa
aaAGTCTCAacaa
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.291
-0.064
-0.291
-0.122
C hsa-miR-1302
hsa-miR-3122
hsa-miR-3147
hsa-miR-3199
hsa-miR-365a-5p
hsa-miR-365b-5p
hsa-miR-3913-5p
hsa-miR-4298
hsa-miR-4425
hsa-miR-8052
3
3
3
7
7
7
3
3
2
7
 aaaGTCCCAAcaa
aaaGTCCCAAcaa
aaagtCCCAACAa
aaAGTCCCAacaa
aAAGTCCCAacaa
aAAGTCCCAacaa
aaaGTCCCAAcaa
aaaGTCCCAAcaa
aaagTCCCAACAa
aaAGTCCCAacaa
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
 -0.165
-0.202
-0.16
-0.158
-0.433
-0.444
-0.221
-0.172
-0.353
-0.175

Genome Browser