SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_014800
Gene Symbol: ELMO1
Description: Homo sapiens engulfment and cell motility 1 (ELMO1), transcript variant 3, mRNA.
Gene Location: chr7(-):36892510-37488555
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.36853044T>G COSN8800357 SS6003115 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-196a-3p catctccTGTTGCCtgcag
 4
 CGGCAACA m7b Disrupted -0.335000 -0.203000 1.180000
hsa-miR-4269 catctcctgGTGCCTGCag
 0 GCAGGCAC m8a (m7a->m8a) no TS -0.164000 0.300000
hsa-miR-4733-3p catctCCTGGTGcctgcag
 0 CCACCAGG m7b Created no TS -0.199000 -4.710000
hsa-miR-4742-5p catctcctgTTGCCTGcag
 3
 UCAGGCAA m7b (m7b->m6b) -0.142000 no TS 0.520000
hsa-miR-4768-3p caTCTCCTGGtgcctgcag
 2
 CCAGGAGA m8a (m7b->m8a) -0.168000 -0.141000 0.100000
hsa-miR-593-5p catctccTGGTGCCTgcag
 0 AGGCACCA m8a Created no TS -0.181000 -5.690000
hsa-miR-665 catCTCCTGGTgcctgcag
 7
 ACCAGGAG m8a Created -0.095000 -0.302000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.36853408C>A COSN9987188 AOCS-163-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1246 agatccAATCCATgaaaaa
 2
 AAUGGAUU m7b Disrupted -0.066000 no TS -0.030000
hsa-miR-490-5p agatccaATCCATGaaaaa
 3
 CCAUGGAU m7b Disrupted -0.258000 no TS 0.220000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.36853843A>C COSN14550953 8066081 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3142 actggAGGCCTTatcagga
 0 AAGGCCUU m7a Created NA NA -1.970000
hsa-miR-3161 actggaggcCTTATCAGga
 0 CUGAUAAG m8a (m7a->m8a) no TS 0.072000 -0.350000
hsa-miR-4753-5p actggaGGCCTTatcagga
 0 CAAGGCCA m6b Created no TS -0.059000 -0.010000
hsa-miR-3142 actggAGGCCTTatcagga
 0 AAGGCCUU m7a Created NA NA -1.970000
hsa-miR-3161 actggaggcCTTATCAGga
 0 CUGAUAAG m8a (m7a->m8a) no TS 0.072000 -0.350000
hsa-miR-4753-5p actggaGGCCTTatcagga
 0 CAAGGCCA m6b Created no TS -0.059000 -0.010000
hsa-miR-3142 actggAGGCCTTatcagga
 0 AAGGCCUU m7a Created NA NA -1.970000
hsa-miR-3161 actggaggcCTTATCAGga
 0 CUGAUAAG m8a (m7a->m8a) no TS 0.072000 -0.350000
hsa-miR-4753-5p actggaGGCCTTatcagga
 0 CAAGGCCA m6b Created no TS -0.059000 -0.010000
hsa-miR-3142 actggAGGCCTTatcagga
 0 AAGGCCUU m7a Created NA NA -1.970000
hsa-miR-3161 actggaggcCTTATCAGga
 0 CUGAUAAG m8a (m7a->m8a) no TS 0.072000 -0.350000
hsa-miR-4753-5p actggaGGCCTTatcagga
 0 CAAGGCCA m6b Created no TS -0.059000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.36854707C>T COSN7979373 8066491 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-455-3p cctctaggaTGGACTGttg
 0 GCAGUCCA m7b (m6b->m7b) no TS -0.131000 -0.850000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.36854818A>C COSN8800358 SS6003317 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-148b-5p caggcCAGAACTgccttct
 3
 AAGUUCUG m7b Disrupted -0.029000 -0.090000 No effect
hsa-miR-2682-5p caggccagaACTGCCTtct
 2
 CAGGCAGU m7b (m7b->m6b) -0.097000 no TS No effect
hsa-miR-34b-5p caggccagaACTGCCTtct
 2
 UAGGCAGU m7b (m7b->m6b) -0.088000 no TS No effect
hsa-miR-4277 caggccAGAACTGCcttct
 2
 GCAGUUCU m8a Disrupted 0.058000 no TS No effect
hsa-miR-449c-5p caggccagaACTGCCTtct
 2
 UAGGCAGU m7b (m7b->m6b) -0.097000 no TS No effect
hsa-miR-4736 caggccagACCTGCCTtct
 0 AGGCAGGU m8a Created no TS -0.131000 -0.030000
hsa-miR-548au-3p caggccagAACTGCCttct
 2
 UGGCAGUU m7b Disrupted -0.197000 -0.139000 No effect
hsa-miR-940 caggccagaCCTGCCTTct
 0 AAGGCAGG m8a (m7a->m8a) no TS -0.096000 0.140000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
36854815 rs3807159 G G hsa-miR-2682-5p
hsa-miR-34b-5p
hsa-miR-3714
hsa-miR-4277
hsa-miR-449c-5p
hsa-miR-548au-3p
hsa-miR-605-3p
2
2
11
2
2
2
12
 agaACTGCCTtct
agaACTGCCTtct
agaaCTGCCTTct
AGAACTGccttct
agaACTGCCTtct
agAACTGCCttct
agaacTGCCTTCt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.097
-0.088
-0.069
0.058
-0.097
-0.058
-0.057
A hsa-miR-148b-5p
hsa-miR-196a-5p
hsa-miR-196b-5p
hsa-miR-3168
hsa-miR-5584-3p
hsa-miR-6874-3p
2
2
2
2
2
2
 AGAACTAccttct
agaACTACCTtct
agaACTACCTtct
AGAACTAccttct
AGAACTAccttct
AGAACTAccttct
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.075
-0.088
-0.098
0.037
0.045
-0.076

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