SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_018127
Gene Symbol:	ELAC2
Description:	Homo sapiens elaC homolog 2 (E. coli) (ELAC2), transcript variant 3, mRNA.
Gene Location:	chr17(-):12894928-12921381
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.12992352G>T			COSN6650610		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3194-3p	tgctaCAGAGCagggtctg	2	AGCUCUGC	m6b	Disrupted	-0.058000	no TS	No effect
hsa-miR-5691	tgctaCAGAGCAgggtctg	2	UUGCUCUG	m7b	Disrupted	-0.080000	no TS	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.12992612C>T			COSN6650611		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.12992667C>G			COSN6650612		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3649	aggcttggGGTCCCacata	0	AGGGACCU	m6b	Created	no TS	-0.199000	-1.370000
hsa-miR-4648	aggcttgggGTCCCACAta	0	UGUGGGAC	m8a	(m7a->m8a)	-0.153000	-0.382000	-6.100000
hsa-miR-505-5p	aggcttgGGCTCCCacata	1	GGGAGCCA	m7a	Disrupted	-0.179000	-0.179000	1.450000
hsa-miR-711	aggcttgGGGTCCCacata	0	GGGACCCA	m7a	Created	NA	NA	-2.740000
hsa-miR-920	aggcttggGCTCCCacata	2	GGGGAGCU	m6b	Disrupted	-0.316000	-0.124000	3.410000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
12992352	rs2286341	G	G	hsa-miR-3194-3p hsa-miR-5691 hsa-miR-6805-3p	2 2 2	taCAGAGCAgggt taCAGAGCAgggt taCAGAGCAgggt	Disrupted Disrupted Disrupted	N N N	-0.058 -0.08 -0.08
12992358	rs143222193	-	TGCTGCT	hsa-miR-15a-5p hsa-miR-15b-5p hsa-miR-16-5p hsa-miR-195-5p hsa-miR-20b-3p hsa-miR-3137 hsa-miR-424-5p hsa-miR-4524a-5p hsa-miR-4524b-5p hsa-miR-497-5p hsa-miR-503-5p hsa-miR-646 hsa-miR-6838-5p	2 2 2 2 2 2 2 2 2 2 2 2 2	tcctgcTGCTGCTAcagagcagggt tcctgcTGCTGCTAcagagcagggt tcctgcTGCTGCTAcagagcagggt tcctgcTGCTGCTAcagagcagggt tcctgctgctgCTACAGAgcagggt tcctgctgctGCTACAGAgcagggt tcctgcTGCTGCTAcagagcagggt tcctgctGCTGCTAcagagcagggt tcctgctGCTGCTAcagagcagggt tcctgcTGCTGCTAcagagcagggt tcctgctGCTGCTAcagagcagggt tcctgctGCTGCTAcagagcagggt tcctgcTGCTGCTAcagagcagggt	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N N N N	-0.254 -0.254 -0.242 -0.253 -0.039 -0.269 -0.235 -0.115 -0.133 -0.254 -0.112 -0.085 -0.293
			-	hsa-miR-3194-3p hsa-miR-5691 hsa-miR-6805-3p	2 2 2	tcctgcaCAGAGCAgggt tcctgcaCAGAGCAgggt tcctgcaCAGAGCAgggt	Unknown Unknown Unknown	N N N	0.011 -0.008 0.02
12992661	rs186146754	C	C	hsa-miR-1233-5p hsa-miR-299-3p hsa-miR-4491 hsa-miR-4648 hsa-miR-4654 hsa-miR-4657 hsa-miR-4769-5p hsa-miR-6778-5p	1 1 1 1 1 1 1 1	CTCCCACAtaagc ctCCCACATAagc ctcCCACATAagc cTCCCACAtaagc cTCCCACAtaagc ctcCCACATAagc cTCCCACAtaagc CTCCCACAtaagc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.358 -0.348 -0.093 -0.153 -0.153 -0.097 -0.153 -0.347
			T	hsa-miR-6871-5p hsa-miR-8076	1 1	CTCCCATAtaagc ctcCCATATAagc	Created Created	N N	-0.299 -0.055
12992667	rs1044564	C	C	hsa-miR-1233-5p hsa-miR-4300 hsa-miR-5591-5p hsa-miR-6090 hsa-miR-6726-5p hsa-miR-6778-5p hsa-miR-6827-5p hsa-miR-920	1 1 1 1 1 1 1 1	cttgggCTCCCAC cttggGCTCCCAc cttggGCTCCCAc cttggGCTCCCAc cttggGCTCCCAc cttgggCTCCCAC cttgGGCTCCCAc cttggGCTCCCAc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.221 -0.182 -0.182 -0.203 -0.182 -0.213 -0.447 -0.192
			G	hsa-miR-3649 hsa-miR-4648	1 1	cttggGGTCCCAc cttgggGTCCCAC	Created Created	N N	-0.199 -0.229

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