SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_022073
Gene Symbol: EGLN3
Description: Homo sapiens egl nine homolog 3 (C. elegans) (EGLN3), mRNA.
Gene Location: chr14(-):34393420-34420284
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr14:g.33924537TA>- ICGC_sm126046 RK024_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-7-5p tatatatataGTCTTCCAaga
 0 UGGAAGAC m8a (m8a->m7a) -0.397000 no TS 0.700000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33924729C>A COSN1645581 RK034_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1205 gcttctactCCTGCAGtaa
 0 UCUGCAGG m7b (m7b->m6b) -0.598000 -0.386000 0.030000
hsa-miR-17-3p gcttctactACTGCAGTaa
 0 ACUGCAGU m8a (m7a->m8a) -0.109000 -0.266000 -0.010000
hsa-miR-199a-3p gcttctACTACTGcagtaa
 4
 ACAGUAGU m7b Created -0.051000 -0.162000 -0.130000
hsa-miR-199b-3p gcttctACTACTGcagtaa
 4
 ACAGUAGU m7b Created -0.051000 -0.162000 -0.130000
hsa-miR-3129-5p gcttctACTACTGCagtaa
 4
 GCAGUAGU m8a Created -0.054000 -0.174000 -0.770000
hsa-miR-4433-3p gcttctACTCCTGcagtaa
 0 ACAGGAGU m7b Disrupted -0.115000 no TS No effect
hsa-miR-4722-5p gcttctaCTCCTGCagtaa
 4
 GGCAGGAG m7b Disrupted -0.516000 -0.205000 No effect
hsa-miR-1205 gcttctactCCTGCAGtaa
 0 UCUGCAGG m7b (m7b->m6b) -0.598000 -0.386000 0.030000
hsa-miR-17-3p gcttctactACTGCAGTaa
 0 ACUGCAGU m8a (m7a->m8a) -0.109000 -0.266000 -0.010000
hsa-miR-199a-3p gcttctACTACTGcagtaa
 4
 ACAGUAGU m7b Created -0.051000 -0.162000 -0.130000
hsa-miR-199b-3p gcttctACTACTGcagtaa
 4
 ACAGUAGU m7b Created -0.051000 -0.162000 -0.130000
hsa-miR-3129-5p gcttctACTACTGCagtaa
 4
 GCAGUAGU m8a Created -0.054000 -0.174000 -0.770000
hsa-miR-4433-3p gcttctACTCCTGcagtaa
 0 ACAGGAGU m7b Disrupted -0.115000 no TS No effect
hsa-miR-4722-5p gcttctaCTCCTGCagtaa
 4
 GGCAGGAG m7b Disrupted -0.516000 -0.205000 No effect
hsa-miR-1205 gcttctactCCTGCAGtaa
 0 UCUGCAGG m7b (m7b->m6b) -0.598 -0.386 0.03
hsa-miR-17-3p gcttctactACTGCAGTaa
 0 ACUGCAGU m8a (m7a->m8a) -0.109 -0.266 -0.01
hsa-miR-199a-3p gcttctACTACTGcagtaa
 0 ACAGUAGU m7b Created -0.051 -0.162 -0.13
hsa-miR-199b-3p gcttctACTACTGcagtaa
 0 ACAGUAGU m7b Created -0.051 -0.162 -0.13
hsa-miR-3129-5p gcttctACTACTGCagtaa
 0 GCAGUAGU m8a Created -0.054 -0.174 -0.77
hsa-miR-4433-3p gcttctACTCCTGcagtaa
 0 ACAGGAGU m7b Disrupted -0.115 no TS No effect
hsa-miR-4722-5p gcttctaCTCCTGCagtaa
 0 GGCAGGAG m7b Disrupted -0.516 -0.205 No effect

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33925158A>T COSN8152030 PCSI_0281_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4777-5p agctaaaaATCTAGAcatt
 15
 UUCUAGAU m7b Created -0.046000 -0.144000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33925222G>A COSN6541808 ICGC_MB127 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4423-5p ataaagatGGCAACacaat
 2
 AGUUGCCU m6b Disrupted -0.142000 no TS 2.170000
hsa-miR-4659a-5p ataaagATGGCAacacaat
 2
 CUGCCAUG m6b Disrupted -0.120000 no TS 0.440000
hsa-miR-4776-3p ataaagATGGCAAcacaat
 2
 CUUGCCAU m7b Disrupted -0.116000 no TS 1.840000
hsa-miR-744-3p ataaagatGGCAACAcaat
 2
 CUGUUGCC m7b Disrupted -0.211000 no TS 1.850000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33925428C>T COSN8588573 381_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1299 gaacaatTTCCAGAtgttc
 12
 UUCUGGAA m7b Disrupted -0.484000 -0.317000 0.030000
hsa-miR-5093 gaacaATTTCCagatgttc
 12
 AGGAAAUG m6b Disrupted -0.035000 -0.035000 No effect
hsa-miR-875-3p gaacaaTTTCCAGatgttc
 12
 CCUGGAAA m7b Disrupted -0.454000 -0.245000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33925518G>A COSN8152031 PCSI_0083_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-335-3p gttTGAAAAAaaaaaaatg
 0 UUUUUCAU m7a (m6b->m7a) no TS 0.018000 -0.050000

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33925554G>A COSN8588574 2275_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-142-5p gcACTTTATGtatacttcc
 20
 CAUAAAGU m8a (m8a->m7b) -0.005000 -0.076000 No effect
hsa-miR-340-5p gcaCTTTATAtatacttcc
 5
 UUAUAAAG m7b (m6c->m7b) 0.118000 0.088000 No effect
hsa-miR-410 gcactTTATATatacttcc
 0 AAUAUAAC m6b Created no TS 0.063000 No effect
hsa-miR-5011-5p gcacttTATATATActtcc
 2
 UAUAUAUA m8a Created -0.251000 -0.275000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr14:g.33925828C>T COSN8588575 2275_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p tcttaaATTCTTTGagatc
 2
 CAAAGAAU m8a Disrupted -0.064000 no TS 0.580000
hsa-miR-3613-3p tcttaaaTTTTTTGagatc
 0 ACAAAAAA m7b Created no TS -0.073000 No effect
hsa-miR-371b-5p tcttaaattTTTTGAGatc
 2
 ACUCAAAA m7b (m6b->m7b) 0.021000 -0.133000 -0.370000
hsa-miR-373-5p tcttaaattTTTTGAGatc
 2
 ACUCAAAA m7b (m6b->m7b) 0.028000 -0.137000 -0.080000
hsa-miR-4282 tcttAAATTTTttgagatc
 0 UAAAAUUU m7b Created no TS -0.026000 -0.050000
hsa-miR-616-5p tcttaaattTTTTGAGatc
 2
 ACUCAAAA m7b (m6b->m7b) 0.004000 -0.164000 -1.090000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
33924537 rs71433636 - - hsa-miR-7-5p
2
 atatataGTCTTCCA
 Unknown
N
 0.004
TA hsa-miR-190a-3p
hsa-miR-5011-5p
2
2
 atATATATAgtcttcca
aTATATATAgtcttcca
 Unknown
Unknown
N
N
 -0.128
-0.12
33924538 rs72393904 - - hsa-miR-190a-3p
hsa-miR-5011-5p
2
2
 tATATATAgtcttcc
TATATATAgtcttcc
 Unknown
Unknown
N
N
 -0.034
0.036
TA hsa-miR-1277-5p
hsa-miR-889-3p
2
2
 tATATATTAagtcttcc
tatATATTAAgtcttcc
 Unknown
Unknown
N
N
 -0.152
0.021
33924539 rs72055657 - - hsa-miR-5011-5p
2
 aTATATATAgtcttc
 Unknown
N
 -0.037
AT hsa-miR-190a-3p
hsa-miR-944
2
2
 ATATATAAttagtcttc
atatATAATTAgtcttc
 Unknown
Unknown
N
N
 0.013
0.039
33924543 rs8021406 T T hsa-miR-190a-3p
hsa-miR-5011-5p
6
5
 tATATATAtatag
TATATATAtatag
 Disrupted
Disrupted
N
N
 -0.27
-0.261
C hsa-miR-3924
21
 tatATACATAtag
 Created
N
 -0.123
33924552 rs35808198 - - hsa-miR-190a-3p
hsa-miR-3678-5p
hsa-miR-4800-3p
hsa-miR-5011-5p
0 tgtacggATATATAt
TGTACGGAtatatat
tgtACGGATAtatat
tgtacggATATATAt
 Unknown
Unknown
Unknown
Unknown
N
N
N
N
 0.128
0.001
0.002
0.12
AT
33925041 rs2383536 C C hsa-miR-199a-3p
hsa-miR-199b-3p
hsa-miR-222-5p
hsa-miR-3129-5p
hsa-miR-3684
hsa-miR-411-5p
hsa-miR-936
4
4
4
4
2
3
4
 ctaggtCTACTGA
ctaggtCTACTGA
ctaggtCTACTGA
ctaggtCTACTGA
ctAGGTCTActga
ctagGTCTACTga
ctaggTCTACTGA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.051
-0.051
-0.112
-0.054
-0.133
-0.11
-0.139
T hsa-miR-545-5p
4
 ctaggTTTACTGA
 Created
N
 -0.019
33925235 rs2383537 C C hsa-miR-506-5p
hsa-miR-892c-5p
2
2
 gactttCTGAATA
gacttTCTGAATA
 Disrupted
Disrupted
N
N
 -0.036
-0.146
T hsa-miR-3613-3p
hsa-miR-4272
8
2
 gacTTTTTGAata
gactttTTGAATA
 Created
Created
N
N
 0.087
0.005
33925271 rs1384373 C C hsa-miR-1827
hsa-miR-1910-3p
hsa-miR-6511a-5p
13
12
14
 gattttCTGCCTC
gatttTCTGCCTc
gatttTCTGCCTc
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.18
-0.143
-0.133
T hsa-miR-3613-3p
hsa-miR-548c-3p
3
3
 gaTTTTTTGcctc
GATTTTTtgcctc
 Created
Created
N
N
 0.146
0.159

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