SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005228
Gene Symbol: EGFR
Description: Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA.
Gene Location: chr7(+):55086724-55275031
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.55205983G>A COSN9994282 AOCS-152-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.55206199T>G 9_113483 CRC-9-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4722-3p caTGGCAGGTacagtagga
 15
 ACCUGCCA m8a (m8a->m7a) -0.176 -0.149 -2.35

Mutation Mutation ID Sample Name Cancer Type
chr7:g.55206294C>T cosmic_v64_1760519 Leukemia/T-ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-132-5p atgtccCCACGGTacttac
 0 ACCGUGGC m7a Disrupted 0 0 0.08
hsa-miR-491-5p atgTCCCCACggtacttac
 0 AGUGGGGA m7b (m7b->m6b) -0.276 -0.164 -3.71
hsa-miR-624-5p atgtccccaTGGTACTtac
 0 UAGUACCA m7b (m6c->m7b) no TS -0.121 -0.4

Mutation Mutation ID Sample Name Cancer Type
chr7:g.55206521G>C COSN8029069 8067180 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-362-5p aatacctAAGGATagcacc
 1
 AAUCCUUG m6b Disrupted 0.019000 no TS 3.350000
hsa-miR-500b aatacctAAGGATagcacc
 1
 AAUCCUUG m6b Disrupted 0.023000 no TS No effect
hsa-miR-501-5p aatacctAAGGATagcacc
 1
 AAUCCUUU m6b Disrupted 0.032000 no TS 0.290000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.55206531G>A COSN9994283 AOCS-108-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1250 gatAGCACCGcttttgttc
 1
 ACGGUGCU m7b (m7b->m6b) -0.256000 no TS 7.180000
hsa-miR-4746-3p gataGCACCGCTtttgttc
 1
 AGCGGUGC m8a Disrupted -0.313000 no TS 3.950000
hsa-miR-4796-3p gatagcaCCACTTTtgttc
 0 UAAAGUGG m7b Created no TS -0.070000 -1.490000
hsa-miR-548t-5p gatagcacCACTTTTGttc
 0 CAAAAGUG m8a Created no TS 0.063000 -0.170000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.55206679G>A COSN8029070 8031146 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374c-5p ttagttTGTATTActtatg
 0 AUAAUACA m7b Created no TS -0.063000 0.440000
hsa-miR-655 ttagttTGTATTActtatg
 0 AUAAUACA m7b Created no TS -0.063000 0.440000
hsa-miR-802 ttagtttgTGTTACTtatg
 1
 CAGUAACA m7b Disrupted -0.069000 no TS 2.740000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.55206898G>A COSN2229449 RK019_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3692-3p agtagTGTGGAAttcaggt
 4
 GUUCCACA m7b Disrupted -0.219000 -0.088000 5.040000
hsa-miR-377-3p agtaGTGTGAaattcaggt
 0 AUCACACA m6b Created no TS -0.098000 No effect
hsa-miR-4452 agtagtgtgGAATTCAggt
 0 UUGAAUUC m7b (m7b->m6c) -0.029000 no TS 0.070000
hsa-miR-3692-3p agtagTGTGGAAttcaggt
 4
 GUUCCACA m7b Disrupted -0.219000 -0.088000 5.040000
hsa-miR-377-3p agtaGTGTGAaattcaggt
 0 AUCACACA m6b Created no TS -0.098000 No effect
hsa-miR-4452 agtagtgtgGAATTCAggt
 0 UUGAAUUC m7b (m7b->m6c) -0.029000 no TS 0.070000
hsa-miR-3692-3p agtagTGTGGAAttcaggt
 4
 GUUCCACA m7b Disrupted -0.219 -0.088 5.04
hsa-miR-377-3p agtaGTGTGAaattcaggt
 0 AUCACACA m6b Created no TS -0.098 No effect
hsa-miR-4452 agtagtgtgGAATTCAggt
 0 UUGAAUUC m7b (m7b->m6c) -0.029 no TS 0.07

Mutation Mutation ID Sample Name Cancer Type
chr7:g.55206942G>T COSN15372586 AOCS-093-3-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p attgataATTCTTTcacaa
 0 CAAAGAAU m7b Created no TS -0.067000 -5.890000
hsa-miR-4422 attgataATGCTTTcacaa
 3
 AAAAGCAU m7b Disrupted -0.113000 no TS 0.100000
hsa-miR-186-5p attgataATTCTTTcacaa
 0 CAAAGAAU m7b Created no TS -0.067000 -5.890000
hsa-miR-4422 attgataATGCTTTcacaa
 3
 AAAAGCAU m7b Disrupted -0.113000 no TS 0.100000
hsa-miR-186-5p attgataATTCTTTcacaa
 0 CAAAGAAU m7b Created no TS -0.067000 -5.890000
hsa-miR-4422 attgataATGCTTTcacaa
 3
 AAAAGCAU m7b Disrupted -0.113000 no TS 0.100000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
55205652 rs17290755 C C hsa-miR-5007-5p
4
 tccAGACTCTttc
 Disrupted
N
 -0.175
T hsa-miR-186-5p
2
 tccagATTCTTTc
 Created
N
 -0.001
55206181 rs192601649 G G hsa-miR-101-3p
hsa-miR-144-3p
8
21
 gGTACTGTAtcaa
ggTACTGTAtcaa
 Disrupted
Disrupted
N
N
 -0.124
0.001
A hsa-miR-624-5p
6
 GGTACTAtatcaa
 Created
N
 -0.106
55206526 rs1063486 G G hsa-miR-1250-5p
hsa-miR-4746-3p
1
1
 aggatAGCACCGc
aggataGCACCGC
 Disrupted
Disrupted
N
N
 -0.256
-0.313
A hsa-miR-4694-5p
1
 aggaTAACACCgc
 Created
N
 -0.077
55206869 rs141571614 C C hsa-miR-1298-5p
hsa-miR-6804-3p
21
2
 caggtgCGAATGA
CAGGTGCgaatga
 Disrupted
Disrupted
N
N
 -0.067
-0.235
T hsa-miR-1228-3p
hsa-miR-377-3p
2
2
 cAGGTGTGAatga
cagGTGTGAAtga
 Created
Created
N
N
 -0.315
-0.081
55206897 rs35473039 - G hsa-miR-3692-3p
4
 tagTGTGGAAttc
 Unknown
N
 -0.131
- hsa-miR-216b-3p
hsa-miR-377-3p
3
3
 tAGTGTGAattc
taGTGTGAAttc
 Unknown
Unknown
N
N
 -0.092
-0.093

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