SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_001178130 |
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Gene Symbol: | EGF |
Description: | Homo sapiens epidermal growth factor (EGF), transcript variant 2, mRNA. |
Gene Location: | chr4(+):110834039-110934118 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.110011628A>C | COSN9584333 | AOCS-125-1-2 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-139-3p |
cttttaagcCGTCTCactg |
0 | GGAGACGC | m6b | Created | no TS | -0.184000 |
-9.830000 |
|
hsa-miR-3672 |
cttttaagcAGTCTCActg |
2 |
AUGAGACU | m7b | (m7b->m6c) | -0.175000 | no TS |
-0.060000 |
|
hsa-miR-4463 |
cttttaagCAGTCTCactg |
0 | GAGACUGG | m7a | Disrupted | NA | NA |
-2.410000 |
|
hsa-miR-873-3p |
cttttaagCAGTCTCactg |
2 |
GGAGACUG | m7b | Disrupted | -0.314000 | no TS |
-0.330000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.110011823G>T | COSN15358316 | 0078_CRUK_PC_0078_T1_DNA | [prostate][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4724-5p |
actggtttGTTCAGTTaca |
0 | AACUGAAC | m8a | Created | no TS | -0.215000 |
-0.010000 |
|
hsa-miR-495 |
actgGTTTGTTcagttaca |
0 | AAACAAAC | m7b | Created | no TS | -0.017000 | No effect | |
hsa-miR-5688 |
actgGTTTGTTcagttaca |
0 | UAACAAAC | m7b | Created | no TS | -0.017000 |
0.040000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.110012381T>C | COSN1285218 | HX12T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3148 |
tttttTTTTTCCggagaga |
1 |
UGGAAAAA | m7b | Disrupted | 0.016000 | 0.028000 | No effect | |
hsa-miR-4497 |
ttttttttTCCCGGAGaga |
0 | CUCCGGGA | m8a | Created | no TS | -0.281000 |
-2.920000 |
|
hsa-miR-4668-5p |
tttttTTTTCCCggagaga |
0 | AGGGAAAA | m7b | Created | -0.087000 | -0.211000 |
-2.730000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.110012383C>G | COSN1979565 | RK005_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3148 |
tttTTTTTCCggagagagg |
1 |
UGGAAAAA | m7b | (m7b->m6b) | 0.016000 | no TS |
0.010000 |
|
hsa-miR-3148 |
tttTTTTTCCggagagagg |
1 |
UGGAAAAA | m7b | (m7b->m6b) | 0.016000 | no TS |
0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.110012498C>A | COSN7723866 | 8034061 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3664-5p |
tcagcctcCAGAGTaacta |
0 | AACUCUGU | m6b | Created | no TS | -0.051000 |
-0.010000 |
|
hsa-miR-4443 |
tcaGCCTCCAgagtaacta |
0 | UUGGAGGC | m7b | (m6b->m7b) | no TS | -0.156000 |
-8.810000 |
|
hsa-miR-4714-5p |
tcagcctcCAGAGTaacta |
0 | AACUCUGA | m6b | Created | no TS | -0.062000 |
-0.410000 |
|
hsa-miR-514a-5p |
tcagcctCCAGAGTAacta |
0 | UACUCUGG | m8a | Created | no TS | -0.271000 |
-0.220000 |
|
hsa-miR-516b-5p |
tcagcCTCCAGAgtaacta |
0 | AUCUGGAG | m7b | Created | no TS | -0.066000 |
-1.690000 |
|
hsa-miR-518c-5p |
tcagccTCCAGAGtaacta |
0 | UCUCUGGA | m7b | Created | no TS | -0.095000 |
-0.820000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr4:g.110012729T>A | COSN4823922 | tumor_4133511 | [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4282 |
ttaaaaAAATTTTttaatc |
1 |
UAAAAUUU | m7b | Disrupted | -0.003000 | -0.003000 |
0.230000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
110011555 | rs56067801 | A | A |
hsa-miR-4752 hsa-miR-5186 hsa-miR-6833-5p |
2 3 2 |
TCCACAAtctcta tccaCAATCTCta TCCACAAtctcta |
Disrupted Disrupted Disrupted |
N N N |
-0.147 -0.181 -0.166 |
G |
hsa-miR-4318 hsa-miR-7114-5p hsa-miR-873-3p |
3 2 3 |
tCCACAGTctcta TCCACAGtctcta tccaCAGTCTCta |
Created Created Created |
N N N |
-0.22 -0.207 -0.205 |
|||
110011737 | rs112146341 | C | C |
hsa-miR-3136-5p hsa-miR-4439 hsa-miR-5002-3p hsa-miR-93-3p hsa-miR-943 |
2 2 2 2 2 |
cttcagCAGTCAA cttcagCAGTCAA cttcaGCAGTCAa ctTCAGCAGtcaa cttcagCAGTCAA |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.144 -0.14 -0.195 -0.241 -0.143 |
T |
hsa-miR-4724-5p |
3 |
cTTCAGTAgtcaa |
Created |
N |
-0.068 |
|||
110012384 | rs112147938 | G | G |
hsa-miR-6845-3p |
1 |
ttttccGGAGAGA |
Disrupted |
N |
-0.078 |
A |
hsa-miR-1299 hsa-miR-3148 hsa-miR-3191-5p hsa-miR-326 hsa-miR-330-5p hsa-miR-518c-5p hsa-miR-6124 hsa-miR-6128 hsa-miR-6764-3p hsa-miR-6817-3p hsa-miR-6824-3p hsa-miR-6873-3p hsa-miR-7110-3p hsa-miR-875-3p |
1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
ttTTCCAGAgaga TTTTCCAgagaga ttttCCAGAGAga ttttCCAGAGAga ttttCCAGAGAga tttTCCAGAGAga TTTTCCAgagaga ttTTCCAGAgaga ttttCCAGAGAga ttttcCAGAGAGA ttttCCAGAGAga ttttccAGAGAGA ttttccAGAGAGA tTTTCCAGAgaga |
Created Created Created Created Created Created Created Created Created Created Created Created Created Created |
N N N N N N N N N N N N N N |
-0.13 -0.038 -0.142 -0.086 -0.086 -0.289 0.016 -0.071 -0.102 -0.165 -0.098 -0.026 -0.101 -0.149 |