SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000115
Gene Symbol:	EDNRB
Description:	Homo sapiens endothelin receptor type B (EDNRB), transcript variant 1, mRNA.
Gene Location:	chr13(-):78469615-78549664
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77896139G>A			COSN7418428		8033471		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4495	agcatacTTACATTattta	4	AAUGUAAA	m7a	Created	0.002000	0.002000	-2.180000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77896433C>T			COSN5264697		SNUH_G26_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1272	attcacaCATCATatggat	0	GAUGAUGA	m6b	Created	no TS	-0.009000	-0.020000
hsa-miR-1322	attcacaCATCATatggat	0	GAUGAUGC	m6b	Created	no TS	-0.022000	-0.360000
hsa-miR-3650	attcACACACCatatggat	1	AGGUGUGU	m7b	Disrupted	-0.220000	no TS	2.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77896630T>C			COSN8587837		3093_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5705	ctttCGAAACAaattgggc	0	UGUUUCGG	m7a	Created	no TS	-0.079000	-8.770000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77896856A>T			COSN6633873		CHC197T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3185	aatttttatTTCTTCTaag	2	AGAAGAAG	m7a	(m6a->m7a)	-0.095000	-0.095000	-0.130000
hsa-miR-4699-5p	aatttttatATCTTCTaag	2	AGAAGAUU	m7a	(m7a->m6a)	-0.109000	-0.109000	0.380000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77897009C>A			COSN9471017		C0086T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5095	taacagctaCCTGTAAagc	7	UUACAGGC	m7a	(m7a->m6a)	-0.006000	no TS	No effect
hsa-miR-552	taacagctACCTGTaaagc	7	AACAGGUG	m6b	Disrupted	-0.045000	no TS	No effect
hsa-miR-582-5p	taacagctAACTGTAAagc	8	UUACAGUU	m8a	Created	-0.078000	-0.081000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77897045T>A			COSN1626461		RK024_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5585-3p	aatactatTATTCAaaatc	2	CUGAAUAG	m6b	Created	-0.166000	-0.144000	-0.030000
hsa-miR-633	aatACTATTAttcaaaatc	1	CUAAUAGU	m7b	(m6c->m7b)	-0.275000	-0.328000	-0.050000
hsa-miR-5585-3p	aatactatTATTCAaaatc	2	CUGAAUAG	m6b	Created	-0.166000	-0.144000	-0.030000
hsa-miR-633	aatACTATTAttcaaaatc	1	CUAAUAGU	m7b	(m6c->m7b)	-0.275000	-0.328000	-0.050000
hsa-miR-5585-3p	aatactatTATTCAaaatc	0	CUGAAUAG	m6b	Created	-0.166	-0.144	-0.03
hsa-miR-633	aatACTATTAttcaaaatc	0	CUAAUAGU	m7b	(m6c->m7b)	-0.275	-0.328	-0.05

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77897228A>T			COSN1626462		RK023_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5696	agatgatTAAATGAGggca	6	CUCAUUUA	m8a	Disrupted	-0.042000	-0.141000	No effect
hsa-miR-5696	agatgatTAAATGAGggca	0	CUCAUUUA	m8a	Disrupted	-0.042	-0.141	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77897539G>T			COSN8421176		AOCS-060-1-5		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-203	aaccaaCATTTCACaaaca	0	GUGAAAUG	m8a	Created	no TS	-0.030000	-0.320000
hsa-miR-3611	aaccaacatTTCACAAaca	0	UUGUGAAG	m7a	(m6a->m7a)	no TS	-0.022000	No effect
hsa-miR-409-3p	aacCAACATTtcacaaaca	0	GAAUGUUG	m7b	(m6c->m7b)	no TS	0.004000	-0.860000
hsa-miR-4504	aaccaacaTGTCACAaaca	1	UGUGACAA	m7a	Disrupted	-0.069000	no TS	No effect
hsa-miR-4781-3p	aaCCAACATTtcacaaaca	2	AAUGUUGG	m8a	(m7b->m8a)	-0.148000	-0.175000	-0.010000
hsa-miR-489	aaccaacATGTCACaaaca	0	GUGACAUC	m7a	Disrupted	NA	NA	0.280000
hsa-miR-542-3p	aaccaacaTGTCACAaaca	1	UGUGACAG	m7a	Disrupted	-0.061000	no TS	0.010000
hsa-miR-758	aaccaacatGTCACAAAca	7	UUUGUGAC	m8a	(m8a->m7a)	-0.213000	-0.053000	0.320000

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.77897989A>G			COSN1626463		RK001_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1245b-5p	aattaagAAGGCCTcgtcg	0	UAGGCCUU	m7b	Created	no TS	-0.199000	-0.120000
hsa-miR-1248	aattAAGAAGGcctcgtcg	0	ACCUUCUU	m7b	Created	no TS	-0.148000	-11.550000
hsa-miR-3142	aattaagAAGGCCTcgtcg	0	AAGGCCUU	m7b	Created	no TS	-0.189000	-0.370000
hsa-miR-3160-5p	aattaAGAAAGCCtcgtcg	14	GGCUUUCU	m8a	Disrupted	-0.230000	-0.072000	1.770000
hsa-miR-3188	aattaagaAAGCCTCgtcg	9	AGAGGCUU	m7b	Disrupted	-0.201000	no TS	2.140000
hsa-miR-1245b-5p	aattaagAAGGCCTcgtcg	0	UAGGCCUU	m7b	Created	no TS	-0.199	-0.12
hsa-miR-1248	aattAAGAAGGcctcgtcg	0	ACCUUCUU	m7b	Created	no TS	-0.148	-11.55
hsa-miR-3142	aattaagAAGGCCTcgtcg	0	AAGGCCUU	m7b	Created	no TS	-0.189	-0.37
hsa-miR-3160-5p	aattaAGAAAGCCtcgtcg	0	GGCUUUCU	m8a	Disrupted	-0.23	-0.072	-7.39
hsa-miR-3188	aattaagaAAGCCTCgtcg	0	AGAGGCUU	m7b	Disrupted	-0.201	no TS	2.14

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
77895560	rs202163485	G	G	hsa-miR-4436b-5p hsa-miR-513b-3p	4 6	cAAGTGGAcatta caagtgGACATTA	Disrupted Disrupted	N N	-0.179 -0.123
			A	hsa-miR-33a-3p hsa-miR-3614-5p hsa-miR-409-3p hsa-miR-6500-3p	6 4 6 4	caagtgAACATTA CAAGTGAacatta caagtgAACATTA CAAGTGAacatta	Created Created Created Created	N N N N	-0.053 -0.129 -0.074 -0.163
77895595	rs201073478	T	T	hsa-miR-4275	5	tacTAATTGAttg	Disrupted	N	-0.078
			A	hsa-miR-4729 hsa-miR-5696	5 5	tacTAAATGAttg tacTAAATGAttg	Created Created	N N	-0.04 -0.098
77896035	rs201086847	C	C	hsa-miR-496 hsa-miR-6869-5p hsa-miR-8055 hsa-miR-8081	2 2 2 2	tacATACTCAaaa tacaTACTCAAaa tacataCTCAAAA tacatACTCAAAa	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.099 -0.08 -0.024 -0.068
			T	hsa-miR-5585-3p	2	tacaTATTCAAaa	Created	N	-0.022
77896391	rs77041871	T	T	hsa-miR-186-5p hsa-miR-3133	0	gTTCTTTAatttc GTTCTTTAatttc	Disrupted Disrupted	N N	0.063 -0.001
			C	hsa-miR-3185 hsa-miR-4709-3p	0	gTTCTTCAatttc gtTCTTCAAtttc	Created Created	N N	0.009 -0.001
77896433	rs3027092	C	C	hsa-miR-3650 hsa-miR-6867-5p	1 1	cACACACCAtatg CACACACcatatg	Disrupted Disrupted	N N	-0.22 -0.144
			T	hsa-miR-1272 hsa-miR-1322	1 1	cacaCATCATAtg cacaCATCATAtg	Created Created	N N	-0.009 -0.022
77896435	rs184732068	C	C	hsa-miR-3650 hsa-miR-6818-5p hsa-miR-6867-5p	1 1 1	ttcACACACCAta tTCACACAccata ttCACACACcata	Disrupted Disrupted Disrupted	N N N	-0.22 -0.101 -0.144
			T	hsa-miR-4501 hsa-miR-5579-5p	1 1	tTCACATAccata ttcacaTACCATA	Created Created	N N	-0.034 -0.056
77896462	rs200248884	A
			G	hsa-miR-1237-3p hsa-miR-1248 hsa-miR-3124-3p hsa-miR-6868-3p	4 4 2 3	cCAGAAGGAaaga ccAGAAGGAaaga ccagaAGGAAAGA ccAGAAGGAAaga	Created Created Created Created	N N N N	-0.058 0.001 -0.037 -0.043
77896804	rs200238819	T
			C	hsa-miR-3160-5p	8	tGAAAGCAtgtac	Created	N	0.04
77897307	rs199926391	T
			A	hsa-miR-1257 hsa-miR-3185	11 8	ttcttCATTCACt TTCTTCAttcact	Created Created	N N	-0.117 -0.026
77897308	rs1050953	C	C	hsa-miR-3185	2	CTTCTTCtttcac	Disrupted	N	-0.095
77897311	rs200568490	C	C	hsa-miR-3185 hsa-miR-4699-5p	2 2	aatCTTCTTCttt AATCTTCttcttt	Disrupted Disrupted	N N	-0.095 -0.109
77897314	rs201833034	C	C	hsa-miR-3185 hsa-miR-4699-5p	2 2	taaaatCTTCTTC taaAATCTTCttc	Disrupted Disrupted	N N	-0.095 -0.109
77897316	rs200208379	A	A	hsa-miR-4699-5p	2	attaaAATCTTCt	Disrupted	N	-0.109
			G	hsa-miR-8087	2	attaAAGTCTTct	Created	N	-0.085
77897712	rs201895581	T
			A	hsa-miR-2053 hsa-miR-569 hsa-miR-633	1 1 1	ctATTAACAgatt ctATTAACAgatt CTATTAAcagatt	Created Created Created	N N N	-0.069 -0.001 -0.045
77897728	rs201149564	T	T	hsa-miR-5692b hsa-miR-5692c	2 2	aattaATATTATc aattaATATTATc	Disrupted Disrupted	N N	-0.03 -0.03
			C	hsa-miR-2053 hsa-miR-33a-3p hsa-miR-409-3p hsa-miR-569	3 2 2 3	aATTAACAttatc aattAACATTAtc aattAACATTAtc aATTAACAttatc	Created Created Created Created	N N N N	-0.11 -0.003 -0.028 -0.028
77897907	rs200767020	C	C	hsa-miR-595	1	acaACACTTAggc	Disrupted	N	-0.056
			T	hsa-miR-409-3p hsa-miR-5009-3p	1 1	aCAACATTtaggc acaacATTTAGGc	Created Created	N N	-0.147 -0.091
77897942	rs199934206	T	T	hsa-miR-4781-3p	2	tCAACATAgctct	Disrupted	N	-0.048
			G	hsa-miR-1267 hsa-miR-367-5p	2 2	TCAACAGAgctct tCAACAGAgctct	Created Created	N N	-0.297 -0.088
77898139	rs74845405	A	A	hsa-miR-1250-3p hsa-miR-153-5p hsa-miR-5696 hsa-miR-579-3p hsa-miR-664b-3p	7 7 7 7 7	aacAAAATGAaac aacAAAATGAaac aacaAAATGAAac aacaAAATGAAac aacaAAATGAAac	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.014 -0.01 -0.019 -0.025 -0.015
			C	hsa-miR-30a-3p hsa-miR-30d-3p hsa-miR-30e-3p hsa-miR-4328 hsa-miR-8068	7 7 7 7 7	aacaaACTGAAAc aacaaACTGAAAc aacaaACTGAAAc aacAAACTGAaac AACAAACtgaaac	Created Created Created Created Created	N N N N N	-0.203 -0.203 -0.203 -0.087 -0.179

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