SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001105544
Gene Symbol: ECHDC1
Description: Homo sapiens enoyl CoA hydratase domain containing 1 (ECHDC1), transcript variant 1, mRNA.
Gene Location: chr6(-):127609856-127664754
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.127289177C>T COSN9295913 AOCS-091-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1244 aaacAACTACTgttgatgt
 2
 AAGUAGUU m7b Disrupted -0.124000 no TS No effect
hsa-miR-199a-3p aaacaACTACTGTtgatgt
 2
 ACAGUAGU m8a Disrupted -0.200000 no TS 0.750000
hsa-miR-199b-3p aaacaACTACTGTtgatgt
 2
 ACAGUAGU m8a Disrupted -0.200000 no TS 0.750000
hsa-miR-3129-5p aaacaACTACTGttgatgt
 2
 GCAGUAGU m7b Disrupted -0.200000 no TS 0.220000
hsa-miR-421 aaacaactaCTGTTGATgt
 2
 AUCAACAG m8a (m8a->m7a) -0.332000 -0.175000 -0.660000
hsa-miR-4703-3p aaaCAACTACtgttgatgt
 2
 UGUAGUUG m7b (m7b->m6c) -0.212000 no TS 0.250000
hsa-miR-4709-5p aaacaactACTGTTGatgt
 2
 ACAACAGU m7b Disrupted -0.547000 -0.283000 1.200000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.127289745T>G COSN1324630 HCC98T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-132-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.110000 -0.930000
hsa-miR-212-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.114000 -0.320000
hsa-miR-548a-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.290000 -0.220000 0.040000
hsa-miR-548ab agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.309000 -0.220000 -0.240000
hsa-miR-548ak agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.270000 -0.191000 0.730000
hsa-miR-548am-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548ap-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.279000 -0.200000 2.220000
hsa-miR-548aq-5p agacTTACTTTtaatcatt
 2
 GAAAGUAA m7b Disrupted -0.291000 -0.202000 1.010000
hsa-miR-548ar-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.309000 -0.220000 0.470000
hsa-miR-548as-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.252000 -0.182000 0.030000
hsa-miR-548au-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.240000
hsa-miR-548av-5p agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.190000
hsa-miR-548b-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.271000 -0.201000 0.020000
hsa-miR-548c-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548d-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.271000 -0.201000 -0.410000
hsa-miR-548h-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.010000
hsa-miR-548i agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.299000 -0.210000 0.650000
hsa-miR-548j agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.279000 -0.200000 2.160000
hsa-miR-548k agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.230000
hsa-miR-548l agactTACTTTTaatcatt
 0 AAAAGUAU m7a Disrupted NA NA No effect
hsa-miR-548n agactTACTTTTaatcatt
 2
 CAAAAGUA m7b Disrupted -0.294000 -0.143000 -0.040000
hsa-miR-548o-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548t-5p agacttACTTTTaatcatt
 0 CAAAAGUG m6b Disrupted -0.286000 -0.268000 0.630000
hsa-miR-548w agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.270000 -0.191000 2.050000
hsa-miR-548y agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.291000 -0.202000 0.930000
hsa-miR-559 agacTTACTTTtaatcatt
 2
 UAAAGUAA m7b Disrupted -0.261000 -0.154000 2.650000
hsa-miR-132-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.110000 -0.930000
hsa-miR-212-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.114000 -0.320000
hsa-miR-548a-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.290000 -0.220000 0.040000
hsa-miR-548ab agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.309000 -0.220000 -0.240000
hsa-miR-548ak agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.270000 -0.191000 0.730000
hsa-miR-548am-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548ap-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.279000 -0.200000 2.220000
hsa-miR-548aq-5p agacTTACTTTtaatcatt
 2
 GAAAGUAA m7b Disrupted -0.291000 -0.202000 1.010000
hsa-miR-548ar-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.309000 -0.220000 0.470000
hsa-miR-548as-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.252000 -0.182000 0.030000
hsa-miR-548au-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.240000
hsa-miR-548av-5p agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.190000
hsa-miR-548b-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.271000 -0.201000 0.020000
hsa-miR-548c-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548d-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.271000 -0.201000 -0.410000
hsa-miR-548h-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.010000
hsa-miR-548i agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.299000 -0.210000 0.650000
hsa-miR-548j agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.279000 -0.200000 2.160000
hsa-miR-548k agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.230000
hsa-miR-548l agactTACTTTTaatcatt
 0 AAAAGUAU m7a Disrupted NA NA No effect
hsa-miR-548n agactTACTTTTaatcatt
 2
 CAAAAGUA m7b Disrupted -0.294000 -0.143000 -0.040000
hsa-miR-548o-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548t-5p agacttACTTTTaatcatt
 0 CAAAAGUG m6b Disrupted -0.286000 -0.268000 0.630000
hsa-miR-548w agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.270000 -0.191000 2.050000
hsa-miR-548y agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.291000 -0.202000 0.930000
hsa-miR-559 agacTTACTTTtaatcatt
 2
 UAAAGUAA m7b Disrupted -0.261000 -0.154000 2.650000
hsa-miR-132-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.110000 -0.930000
hsa-miR-212-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.114000 -0.320000
hsa-miR-548a-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.290000 -0.220000 0.040000
hsa-miR-548ab agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.309000 -0.220000 -0.240000
hsa-miR-548ak agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.270000 -0.191000 0.730000
hsa-miR-548am-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548ap-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.279000 -0.200000 2.220000
hsa-miR-548aq-5p agacTTACTTTtaatcatt
 2
 GAAAGUAA m7b Disrupted -0.291000 -0.202000 1.010000
hsa-miR-548ar-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.309000 -0.220000 0.470000
hsa-miR-548as-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.252000 -0.182000 0.030000
hsa-miR-548au-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.240000
hsa-miR-548av-5p agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.190000
hsa-miR-548b-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.271000 -0.201000 0.020000
hsa-miR-548c-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548d-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.271000 -0.201000 -0.410000
hsa-miR-548h-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.010000
hsa-miR-548i agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.299000 -0.210000 0.650000
hsa-miR-548j agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.279000 -0.200000 2.160000
hsa-miR-548k agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.230000
hsa-miR-548l agactTACTTTTaatcatt
 0 AAAAGUAU m7a Disrupted NA NA No effect
hsa-miR-548n agactTACTTTTaatcatt
 2
 CAAAAGUA m7b Disrupted -0.294000 -0.143000 -0.040000
hsa-miR-548o-5p agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.261000 -0.191000 0.570000
hsa-miR-548t-5p agacttACTTTTaatcatt
 0 CAAAAGUG m6b Disrupted -0.286000 -0.268000 0.630000
hsa-miR-548w agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.270000 -0.191000 2.050000
hsa-miR-548y agacTTACTTTTaatcatt
 2
 AAAAGUAA m8a Disrupted -0.291000 -0.202000 0.930000
hsa-miR-559 agacTTACTTTtaatcatt
 2
 UAAAGUAA m7b Disrupted -0.261000 -0.154000 2.650000
hsa-miR-132-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.11 -0.93
hsa-miR-212-3p agacttACTGTTAatcatt
 0 UAACAGUC m7a Created no TS -0.114 -0.32
hsa-miR-548a-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.29 -0.22 0.04
hsa-miR-548ab agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.309 -0.22 -0.24
hsa-miR-548ak agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.27 -0.191 0.73
hsa-miR-548am-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.261 -0.191 0.57
hsa-miR-548ap-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.279 -0.2 2.22
hsa-miR-548aq-5p agacTTACTTTtaatcatt
 0 GAAAGUAA m7b Disrupted -0.291 -0.202 1.01
hsa-miR-548ar-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.309 -0.22 0.47
hsa-miR-548as-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.252 -0.182 0.03
hsa-miR-548au-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.261 -0.191 0.24
hsa-miR-548av-5p agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.19
hsa-miR-548b-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.271 -0.201 0.02
hsa-miR-548c-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.261 -0.191 0.57
hsa-miR-548d-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.271 -0.201 -0.41
hsa-miR-548h-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.261 -0.191 0.01
hsa-miR-548i agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.299 -0.21 0.65
hsa-miR-548j agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.279 -0.2 2.16
hsa-miR-548k agactTACTTTTaatcatt
 0 AAAAGUAC m7a Disrupted NA NA 0.23
hsa-miR-548l agactTACTTTTaatcatt
 0 AAAAGUAU m7a Disrupted NA NA No effect
hsa-miR-548n agactTACTTTTaatcatt
 0 CAAAAGUA m7b Disrupted -0.294 -0.143 -0.04
hsa-miR-548o-5p agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.261 -0.191 0.57
hsa-miR-548t-5p agacttACTTTTaatcatt
 0 CAAAAGUG m6b Disrupted -0.286 -0.268 0.63
hsa-miR-548w agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.27 -0.191 2.05
hsa-miR-548y agacTTACTTTTaatcatt
 0 AAAAGUAA m8a Disrupted -0.291 -0.202 0.93
hsa-miR-559 agacTTACTTTtaatcatt
 0 UAAAGUAA m7b Disrupted -0.261 -0.154 2.65

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
127289172 rs113257155 G G hsa-miR-421
hsa-miR-4709-5p
hsa-miR-499a-3p
hsa-miR-499b-3p
2
2
2
2
 aCTGTTGAtgtag
ACTGTTGAtgtag
actgtTGATGTAg
actgtTGATGTAg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.157
-0.264
-0.063
-0.063

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