SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_003583
Gene Symbol:	DYRK2
Description:	Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA.
Gene Location:	chr12(+):68042511-68056444
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.67659020G>A			COSN1582136		RK126_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-147a	gactgCCACACAtttacag	0	GUGUGUGG	m7b	Created	no TS	-0.171000	No effect
hsa-miR-644a	gactGCCACACatttacag	0	AGUGUGGC	m7b	Created	no TS	-0.436000	No effect
hsa-miR-147a	gactgCCACACAtttacag	0	GUGUGUGG	m7b	Created	no TS	-0.171	No effect
hsa-miR-644a	gactGCCACACatttacag	0	AGUGUGGC	m7b	Created	no TS	-0.436	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.67660302G>A			COSN9754277		C0004T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1304-3p	tggtcccCAGTGAGgccaa	12	UCUCACUG	m7b	Disrupted	0.112000	no TS	1.560000
hsa-miR-450a-3p	tggTCCCCAATgaggccaa	6	AUUGGGGA	m8a	Created	-0.209000	-0.170000	-0.100000
hsa-miR-4667-5p	tggTCCCCAGTgaggccaa	0	ACUGGGGA	m8a	Disrupted	-0.167000	-0.203000	0.030000
hsa-miR-4700-5p	tggTCCCCAGtgaggccaa	0	UCUGGGGA	m7b	(m7b->m6b)	-0.188000	-0.215000	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.67661030A>G			COSN8586572		J10_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3617	tttgagacTGTCTTTattt	19	AAAGACAU	m7a	Created	-0.004000	-0.004000	No effect
hsa-miR-4474-5p	tttGAGACTAtctttattt	1	UUAGUCUC	m7b	(m7b->m6b)	-0.100000	no TS	0.380000
hsa-miR-4662a-3p	tttgagaCTATCTTTattt	16	AAAGAUAG	m8a	Disrupted	0.062000	0.076000	0.010000
hsa-miR-548u	tttgagactGTCTTTattt	0	CAAAGACU	m6b	Created	no TS	0.069000	-0.100000
hsa-miR-641	tttgagacTGTCTTTattt	19	AAAGACAU	m7a	Created	-0.004000	-0.004000	0.160000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.67661179C>A			COSN9473898		AOCS-130-1-0		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-34a-3p	atagaGCTGATTtaataaa	2	CAAUCAGC	m7b	Created	-0.028000	-0.123000	No effect
hsa-miR-4422	atagagcTGCTTTaataaa	0	AAAAGCAU	m6b	Disrupted	-0.111000	-0.177000	No effect
hsa-miR-4660	ataGAGCTGCtttaataaa	6	UGCAGCUC	m7b	(m7b->m6b)	-0.283000	-0.108000	0.240000
hsa-miR-551b-5p	atagagcTGATTTaataaa	11	GAAAUCAA	m6b	Created	0.176000	0.303000	No effect
hsa-miR-646	atagAGCTGCTTtaataaa	7	AAGCAGCU	m8a	Disrupted	-0.077000	no TS	No effect
hsa-miR-9-3p	atagagctGCTTTAataaa	0	AUAAAGCU	m6b	Disrupted	-0.020000	-0.088000	0.190000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.67662277A>G			COSN7618556		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4708-5p	ggggcttgtGCATCTCTct	0	AGAGAUGC	m8a	(m7b->m8a)	0.053000	-0.121000	-3.250000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
67661158	rs186367036	C	C	hsa-miR-1273f hsa-miR-143-3p hsa-miR-4663 hsa-miR-4708-5p hsa-miR-4728-3p hsa-miR-4770 hsa-miR-6088 hsa-miR-7160-5p hsa-miR-8077	0	aCATCTCAgcatt aCATCTCAgcatt acatCTCAGCAtt aCATCTCAgcatt acatcTCAGCATt aCATCTCAgcatt aCATCTCAgcatt acatCTCAGCAtt acatCTCAGCAtt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	0.072 0.065 -0.028 0.053 0.004 0.062 0.072 -0.008 -0.024
			G	hsa-miR-1245b-3p hsa-miR-3934-3p hsa-miR-4330	0	aCATCTGAgcatt acatCTGAGCAtt acATCTGAGcatt	Created Created Created	N N N	0.069 -0.029 0.041

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