SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_013235
Gene Symbol: DROSHA
Description: Homo sapiens drosha, ribonuclease type III (DROSHA), transcript variant 2, mRNA.
Gene Location: chr5(-):31400601-31532282
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.31400621T>C COSN2102286 RK023_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1303 ttatcagccTCTCTAAgtg
 4
 UUUAGAGA m7b (m7b->m6b) -0.082000 -0.047000 0.310000
hsa-miR-185-3p ttatCAGCCCCTctaagtg
 0 AGGGGCUG m8a Created no TS -0.302000 -1.950000
hsa-miR-3184-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.312000 -2.890000
hsa-miR-3929 ttaTCAGCCTCtctaagtg
 1
 GAGGCUGA m8a Disrupted -0.223000 no TS 0.110000
hsa-miR-423-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.322000 -2.890000
hsa-miR-4419b ttaTCAGCCTCtctaagtg
 1
 GAGGCUGA m8a Disrupted -0.233000 no TS 1.260000
hsa-miR-4478 ttaTCAGCCTCtctaagtg
 1
 GAGGCUGA m8a Disrupted -0.223000 no TS 0.020000
hsa-miR-4656 ttaTCAGCCCctctaagtg
 0 UGGGCUGA m7b (m6c->m7b) no TS -0.265000 No effect
hsa-miR-485-5p ttatCAGCCTCTctaagtg
 1
 AGAGGCUG m8a Disrupted -0.239000 no TS 5.580000
hsa-miR-877-5p ttatcagccCCTCTAagtg
 0 GUAGAGGA m6b Created no TS -0.102000 -0.620000
hsa-miR-1303 ttatcagccTCTCTAAgtg
 0 UUUAGAGA m7b (m7b->m6b) -0.082 -0.047 0.31
hsa-miR-185-3p ttatCAGCCCCTctaagtg
 0 AGGGGCUG m8a Created no TS -0.302 -1.95
hsa-miR-3184-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.312 -2.89
hsa-miR-3929 ttaTCAGCCTCtctaagtg
 0 GAGGCUGA m8a Disrupted -0.223 no TS 0.11
hsa-miR-423-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.322 -2.89
hsa-miR-4419b ttaTCAGCCTCtctaagtg
 0 GAGGCUGA m8a Disrupted -0.233 no TS 1.26
hsa-miR-4478 ttaTCAGCCTCtctaagtg
 0 GAGGCUGA m8a Disrupted -0.223 no TS 0.02
hsa-miR-4656 ttaTCAGCCCctctaagtg
 0 UGGGCUGA m7b (m6c->m7b) no TS -0.265 No effect
hsa-miR-485-5p ttatCAGCCTCTctaagtg
 0 AGAGGCUG m8a Disrupted -0.239 no TS 5.58
hsa-miR-877-5p ttatcagccCCTCTAagtg
 0 GUAGAGGA m6b Created no TS -0.102 -0.62

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31400633C>A COSN7937588 8053200 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3163 ggtttatagATTTTATcag
 0 UAUAAAAU m7b (m6b->m7b) no TS 0.127000 -0.080000
hsa-miR-320a ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-320b ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.093000 -0.093000 No effect
hsa-miR-320c ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-320d ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-4429 ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-4668-3p ggtttataGATTTTatcag
 2
 GAAAAUCC m6b Created -0.100000 -0.074000 -2.210000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31400988C>T COSN9949482 C0059T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-320a ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.570000
hsa-miR-320b ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.093000 -0.121000 0.550000
hsa-miR-320c ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.590000
hsa-miR-320d ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.590000
hsa-miR-4429 ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.590000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401033A>G COSN6293987 RK190_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5683 gtaaCATCTGTcctttttc
 0 UACAGAUG m7b Created -0.078000 -0.215000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401176T>C COSN5160688 PD3945a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1276 tttGCTCTTTAaataataa
 4
 UAAAGAGC m8a Disrupted -0.369000 no TS 4.000000
hsa-miR-4311 tttgCTCTTTaaataataa
 4
 GAAAGAGA m6b Disrupted -0.076000 no TS 1.120000
hsa-miR-4709-3p tttgCTCTTCAAataataa
 0 UUGAAGAG m8a Created no TS -0.293000 -1.650000
hsa-miR-583 tttgCTCTTTaaataataa
 4
 CAAAGAGG m6b Disrupted -0.084000 no TS 0.390000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401285G>T COSN5272709 SNUH_G26_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5694 tgttttaATGATCTGtttt
 0 CAGAUCAU m8a Disrupted -0.205000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401340T>C COSN15330778 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-664-3p gacAATGAATgaagtgtgc
 0 UAUUCAUU m7b (m7b->m6c) -0.033000 no TS 0.520000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401345A>G COSN6293988 RK162_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1208 ctgcagACAGTGAatgaag
 0 UCACUGUU m7a Created no TS -0.136000 -2.620000
hsa-miR-181b-3p ctgcagaCAGTGAatgaag
 0 CUCACUGA m6b Created no TS -0.111000 -0.770000
hsa-miR-3120-5p ctgCAGACAGtgaatgaag
 0 CCUGUCUG m7b (m6c->m7b) no TS -0.172000 -6.340000
hsa-miR-4288 ctGCAGACAAtgaatgaag
 0 UUGUCUGC m8a (m8a->m7b) -0.411000 -0.215000 0.840000
hsa-miR-4289 ctgcagACAATGaatgaag
 0 GCAUUGUG m6b Disrupted -0.089000 no TS 9.020000
hsa-miR-4420 ctgcagaCAGTGAatgaag
 0 GUCACUGA m6b Created no TS -0.107000 -0.630000
hsa-miR-664-3p ctgcagacAATGAATgaag
 0 UAUUCAUU m7b Disrupted -0.033000 no TS 0.350000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
31400991 rs28527453 T T hsa-miR-320a
hsa-miR-320b
hsa-miR-320c
hsa-miR-320d
hsa-miR-4429
8
8
8
8
8
 ttCAGCTTTcatc
ttCAGCTTTcatc
ttCAGCTTTcatc
ttCAGCTTTcatc
ttCAGCTTTcatc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.074
-0.093
-0.074
-0.074
-0.074
C hsa-miR-3929
hsa-miR-4419b
hsa-miR-4478
hsa-miR-4493
hsa-miR-605-3p
hsa-miR-6126
8
8
8
11
11
11
 tTCAGCCTtcatc
tTCAGCCTtcatc
tTCAGCCTtcatc
ttcaGCCTTCAtc
ttcaGCCTTCAtc
ttcaGCCTTCAtc
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.176
-0.167
-0.139
-0.122
-0.097
-0.134
31401285 rs150603393 G G hsa-miR-1288-5p
hsa-miR-5694
2
2
 tttaaTGATCTGt
tttaATGATCTgt
 Disrupted
Disrupted
N
N
 -0.267
-0.205
31401393 rs72547276 A A hsa-miR-935
3
 ctcaGTAACTGtg
 Disrupted
N
 -0.153
G hsa-miR-181b-3p
hsa-miR-4420
hsa-miR-4704-3p
2
2
3
 cTCAGTGActgtg
cTCAGTGActgtg
ctcaGTGACTGtg
 Created
Created
Created
N
N
N
 -0.14
-0.149
-0.21

Genome Browser