SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001100412
Gene Symbol: DROSHA
Description: Homo sapiens drosha, ribonuclease type III (DROSHA), transcript variant 2, mRNA.
Gene Location: chr5(-):31400601-31532282
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.31400621T>C COSN2102286 RK023_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1303 ttatcagccTCTCTAAgtg
 4
 UUUAGAGA m7b (m7b->m6b) -0.082000 -0.047000 0.310000
hsa-miR-185-3p ttatCAGCCCCTctaagtg
 0 AGGGGCUG m8a Created no TS -0.302000 -1.950000
hsa-miR-3184-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.312000 -2.890000
hsa-miR-3929 ttaTCAGCCTCtctaagtg
 1
 GAGGCUGA m8a Disrupted -0.223000 no TS 0.110000
hsa-miR-423-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.322000 -2.890000
hsa-miR-4419b ttaTCAGCCTCtctaagtg
 1
 GAGGCUGA m8a Disrupted -0.233000 no TS 1.260000
hsa-miR-4478 ttaTCAGCCTCtctaagtg
 1
 GAGGCUGA m8a Disrupted -0.223000 no TS 0.020000
hsa-miR-4656 ttaTCAGCCCctctaagtg
 0 UGGGCUGA m7b (m6c->m7b) no TS -0.265000 No effect
hsa-miR-485-5p ttatCAGCCTCTctaagtg
 1
 AGAGGCUG m8a Disrupted -0.239000 no TS 5.580000
hsa-miR-877-5p ttatcagccCCTCTAagtg
 0 GUAGAGGA m6b Created no TS -0.102000 -0.620000
hsa-miR-1303 ttatcagccTCTCTAAgtg
 0 UUUAGAGA m7b (m7b->m6b) -0.082 -0.047 0.31
hsa-miR-185-3p ttatCAGCCCCTctaagtg
 0 AGGGGCUG m8a Created no TS -0.302 -1.95
hsa-miR-3184-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.312 -2.89
hsa-miR-3929 ttaTCAGCCTCtctaagtg
 0 GAGGCUGA m8a Disrupted -0.223 no TS 0.11
hsa-miR-423-5p ttatcaGCCCCTCtaagtg
 0 UGAGGGGC m7b Created no TS -0.322 -2.89
hsa-miR-4419b ttaTCAGCCTCtctaagtg
 0 GAGGCUGA m8a Disrupted -0.233 no TS 1.26
hsa-miR-4478 ttaTCAGCCTCtctaagtg
 0 GAGGCUGA m8a Disrupted -0.223 no TS 0.02
hsa-miR-4656 ttaTCAGCCCctctaagtg
 0 UGGGCUGA m7b (m6c->m7b) no TS -0.265 No effect
hsa-miR-485-5p ttatCAGCCTCTctaagtg
 0 AGAGGCUG m8a Disrupted -0.239 no TS 5.58
hsa-miR-877-5p ttatcagccCCTCTAagtg
 0 GUAGAGGA m6b Created no TS -0.102 -0.62

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31400633C>A COSN7937588 8053200 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3163 ggtttatagATTTTATcag
 0 UAUAAAAU m7b (m6b->m7b) no TS 0.127000 -0.080000
hsa-miR-320a ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-320b ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.093000 -0.093000 No effect
hsa-miR-320c ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-320d ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-4429 ggtttatAGCTTTTatcag
 8
 AAAAGCUG m7a Disrupted -0.074000 -0.074000 No effect
hsa-miR-4668-3p ggtttataGATTTTatcag
 2
 GAAAAUCC m6b Created -0.100000 -0.074000 -2.210000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31400988C>T COSN9949482 C0059T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-320a ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.570000
hsa-miR-320b ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.093000 -0.121000 0.550000
hsa-miR-320c ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.590000
hsa-miR-320d ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.590000
hsa-miR-4429 ttCAGCTTTTatccggtgg
 8
 AAAAGCUG m8a (m7b->m8a) -0.074000 -0.102000 0.590000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401033A>G COSN6293987 RK190_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5683 gtaaCATCTGTcctttttc
 0 UACAGAUG m7b Created -0.078000 -0.215000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401176T>C COSN5160688 PD3945a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1276 tttGCTCTTTAaataataa
 4
 UAAAGAGC m8a Disrupted -0.369000 no TS 4.000000
hsa-miR-4311 tttgCTCTTTaaataataa
 4
 GAAAGAGA m6b Disrupted -0.076000 no TS 1.120000
hsa-miR-4709-3p tttgCTCTTCAAataataa
 0 UUGAAGAG m8a Created no TS -0.293000 -1.650000
hsa-miR-583 tttgCTCTTTaaataataa
 4
 CAAAGAGG m6b Disrupted -0.084000 no TS 0.390000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401285G>T COSN5272709 SNUH_G26_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5694 tgttttaATGATCTGtttt
 0 CAGAUCAU m8a Disrupted -0.205000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401340T>C COSN15330778 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-664-3p gacAATGAATgaagtgtgc
 0 UAUUCAUU m7b (m7b->m6c) -0.033000 no TS 0.520000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.31401345A>G COSN6293988 RK162_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1208 ctgcagACAGTGAatgaag
 0 UCACUGUU m7a Created no TS -0.136000 -2.620000
hsa-miR-181b-3p ctgcagaCAGTGAatgaag
 0 CUCACUGA m6b Created no TS -0.111000 -0.770000
hsa-miR-3120-5p ctgCAGACAGtgaatgaag
 0 CCUGUCUG m7b (m6c->m7b) no TS -0.172000 -6.340000
hsa-miR-4288 ctGCAGACAAtgaatgaag
 0 UUGUCUGC m8a (m8a->m7b) -0.411000 -0.215000 0.840000
hsa-miR-4289 ctgcagACAATGaatgaag
 0 GCAUUGUG m6b Disrupted -0.089000 no TS 9.020000
hsa-miR-4420 ctgcagaCAGTGAatgaag
 0 GUCACUGA m6b Created no TS -0.107000 -0.630000
hsa-miR-664-3p ctgcagacAATGAATgaag
 0 UAUUCAUU m7b Disrupted -0.033000 no TS 0.350000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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