| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_000795 |
|---|---|
| Gene Symbol: | DRD2 |
| Description: | Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. |
| Gene Location: | chr11(-):113280316-113346001 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr11:g.113409948C>T | COSN1514440 | RK092_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-193a-3p |
gctGGCCAGTctggggcct |
0 | AACUGGCC | m7b | (m6c->m7b) | no TS | -0.172000 |
-0.220000 |
|
| hsa-miR-193b-3p |
gctGGCCAGTctggggcct |
0 | AACUGGCC | m7b | (m6c->m7b) | no TS | -0.172000 |
-0.160000 |
|
| hsa-miR-4463 |
gctggCCAGTCTggggcct |
0 | GAGACUGG | m7b | Created | no TS | -0.035000 |
-2.570000 |
|
| hsa-miR-4494 |
gctggcCAGTCTGGggcct |
0 | CCAGACUG | m8a | Created | no TS | -0.007000 | No effect | |
| hsa-miR-193a-3p |
gctGGCCAGTctggggcct |
0 | AACUGGCC | m7b | (m6c->m7b) | no TS | -0.172 |
-0.22 |
|
| hsa-miR-193b-3p |
gctGGCCAGTctggggcct |
0 | AACUGGCC | m7b | (m6c->m7b) | no TS | -0.172 |
-0.16 |
|
| hsa-miR-4463 |
gctggCCAGTCTggggcct |
0 | GAGACUGG | m7b | Created | no TS | -0.035 |
-2.57 |
|
| hsa-miR-4494 |
gctggcCAGTCTGGggcct |
0 | CCAGACUG | m8a | Created | no TS | -0.007 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr11:g.113410158C>T | COSN8732583 | AOCS-134-3-9 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-342-5p |
ctcccGCACCCCgatgtgg |
0 | AGGGGUGC | m7b | Disrupted | -0.126000 | no TS |
1.540000 |
|
| hsa-miR-4466 |
ctcCCGCACCCcgatgtgg |
0 | GGGUGCGG | m8a | Disrupted | -0.179000 | no TS |
1.870000 |
|
| hsa-miR-4651 |
ctcccgCACCCCGatgtgg |
0 | CGGGGUGG | m7a | Disrupted | NA | NA |
0.320000 |
|
| hsa-miR-4664-5p |
ctcccGCACCCCgatgtgg |
0 | UGGGGUGC | m7b | Disrupted | -0.126000 | no TS |
2.690000 |
|
| hsa-miR-675-5p |
ctcCCGCACCccgatgtgg |
0 | UGGUGCGG | m7b | (m7b->m6c) | -0.207000 | no TS |
2.220000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr11:g.113410162G>A | COSN6985996 | 8067246 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-30b-3p |
ctcCCTCCCAcaccccgat |
1 |
CUGGGAGG | m7b | (m6c->m7b) | -0.059000 | -0.157000 |
-0.020000 |
|
| hsa-miR-342-5p |
ctccctcccGCACCCCgat |
0 | AGGGGUGC | m7b | (m7b->m6b) | -0.126000 | no TS |
0.940000 |
|
| hsa-miR-3689a-3p |
ctcCCTCCCAcaccccgat |
1 |
CUGGGAGG | m7b | (m6c->m7b) | -0.078000 | -0.157000 |
-0.070000 |
|
| hsa-miR-3689b-3p |
ctcCCTCCCAcaccccgat |
1 |
CUGGGAGG | m7b | (m6c->m7b) | -0.078000 | -0.157000 |
-0.030000 |
|
| hsa-miR-3689c |
ctcCCTCCCAcaccccgat |
1 |
CUGGGAGG | m7b | (m6c->m7b) | -0.078000 | -0.157000 |
-0.030000 |
|
| hsa-miR-4455 |
ctccctccCACACCCcgat |
3 |
AGGGUGUG | m7b | Created | -0.282000 | -0.331000 |
-0.020000 |
|
| hsa-miR-4466 |
ctccctcCCGCACCCcgat |
0 | GGGUGCGG | m8a | Disrupted | -0.179000 | no TS |
3.560000 |
|
| hsa-miR-4664-5p |
ctccctcccGCACCCCgat |
0 | UGGGGUGC | m7b | (m7b->m6b) | -0.126000 | no TS |
3.070000 |
|
| hsa-miR-4728-5p |
ctCCCTCCCAcaccccgat |
0 | UGGGAGGG | m8a | (m7b->m8a) | -0.397000 | -0.556000 | No effect | |
| hsa-miR-4769-5p |
ctcccTCCCACaccccgat |
0 | GGUGGGAU | m6b | Created | no TS | -0.091000 |
-0.030000 |
|
| hsa-miR-675-5p |
ctccctcCCGCACCccgat |
0 | UGGUGCGG | m7b | Disrupted | -0.207000 | no TS |
6.000000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr11:g.113410184C>T | COSN14504035 | 8070208 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr11:g.113410452C>T | COSN8338600 | 0007_CRUK_PC_0007_T3_DNA | [prostate][NS][carcinoma][adenocarcinoma] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-1321 |
cctccagtCTCCCTatcct |
7 |
CAGGGAGG | m6b | Created | -0.118000 | -0.209000 |
-0.090000 |
| hsa-miR-135a-3p |
cctccagtcTCCCTATcct |
0 | UAUAGGGA | m7b | (m6b->m7b) | no TS | -0.122000 |
-0.700000 |
| hsa-miR-3162-5p |
cctccagtCTCCCTAtcct |
0 | UUAGGGAG | m7b | Created | no TS | -0.192000 |
-5.040000 |
| hsa-miR-3199 |
cctcCAGTCCCcctatcct |
0 | AGGGACUG | m7b | Disrupted | -0.148000 | no TS |
0.010000 |
| hsa-miR-4278 |
cctccagtCCCCCTAtcct |
2 |
CUAGGGGG | m7b | Disrupted | -0.200000 | no TS |
2.800000 |
| hsa-miR-4463 |
cctCCAGTCTCcctatcct |
0 | GAGACUGG | m8a | Created | no TS | -0.154000 |
-6.760000 |
| hsa-miR-4515 |
cctCCAGTCCccctatcct |
0 | AGGACUGG | m7b | (m7b->m6c) | -0.151000 | no TS | No effect |
| hsa-miR-4652-5p |
cctccAGTCCCCctatcct |
0 | AGGGGACU | m7b | Disrupted | -0.271000 | -0.134000 |
2.500000 |
| hsa-miR-4716-3p |
cctccagTCCCCCTatcct |
1 |
AAGGGGGA | m7b | Disrupted | -0.364000 | no TS |
2.810000 |
| hsa-miR-4739 |
cctccagtCTCCCTatcct |
7 |
AAGGGAGG | m6b | Created | -0.137000 | -0.228000 | No effect |
| hsa-miR-4756-5p |
cctccagtCTCCCTatcct |
7 |
CAGGGAGG | m6b | Created | -0.127000 | -0.204000 |
-0.240000 |
| hsa-miR-5010-5p |
cctccagTCCCCCTatcct |
0 | AGGGGGAU | m7a | Disrupted | NA | NA |
0.520000 |
| hsa-miR-625-5p |
cctccagTCCCCCTatcct |
0 | AGGGGGAA | m7a | Disrupted | NA | NA |
3.500000 |
| hsa-miR-873-3p |
cctcCAGTCTCCctatcct |
0 | GGAGACUG | m8a | Created | no TS | -0.076000 |
-4.600000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 113410097 | rs201729901 | C | C |
hsa-miR-1343-5p hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-3175 hsa-miR-3614-5p hsa-miR-450a-2-3p hsa-miR-6763-5p hsa-miR-6810-5p hsa-miR-6825-5p hsa-miR-6857-5p hsa-miR-939-5p |
4 1 1 4 1 1 1 1 4 1 4 |
GCTCCCCAagtgg gcTCCCCAAgtgg gCTCCCCAAgtgg gCTCCCCAagtgg gctccCCAAGTGg gcTCCCCAAgtgg gCTCCCCAAgtgg gcTCCCCAAgtgg gCTCCCCAagtgg gcTCCCCAAgtgg GCTCCCCAagtgg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N N |
-0.394 -0.087 -0.245 -0.124 -0.049 -0.059 -0.277 -0.089 -0.109 -0.098 -0.373 |
| T |
hsa-miR-1321 hsa-miR-3162-5p hsa-miR-4739 hsa-miR-4756-5p hsa-miR-6760-5p |
4 1 4 4 4 |
gCTCCCTAagtgg gCTCCCTAAgtgg gCTCCCTAagtgg gCTCCCTAagtgg gCTCCCTAagtgg |
Created Created Created Created Created |
N N N N N |
-0.089 -0.267 -0.093 -0.086 -0.095 |
|||
| 113410133 | rs202236974 | G | G |
hsa-miR-1254 hsa-miR-3116 hsa-miR-4293 hsa-miR-596 |
1 1 1 1 |
tTCCAGGCtagtc tTCCAGGCtagtc ttcCAGGCTAgtc ttcCAGGCTAgtc |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.19 -0.209 -0.091 -0.097 |
| T |
hsa-miR-151a-3p hsa-miR-4463 hsa-miR-4499 |
1 1 1 |
ttcCAGTCTAgtc ttCCAGTCTAgtc ttcCAGTCTAgtc |
Created Created Created |
N N N |
-0.054 -0.246 -0.058 |
|||
| 113410155 | rs199695073 | A | |||||||
| A |
hsa-miR-3170 hsa-miR-342-5p hsa-miR-4651 hsa-miR-4664-5p hsa-miR-5572 hsa-miR-608 hsa-miR-6737-5p hsa-miR-6747-5p hsa-miR-6812-5p hsa-miR-6819-5p hsa-miR-6855-5p |
0 |
cACCCCAAtgtgg CACCCCAatgtgg CACCCCAatgtgg CACCCCAatgtgg cACCCCAAtgtgg CACCCCAatgtgg CACCCCAAtgtgg CACCCCAatgtgg CACCCCAAtgtgg CACCCCAAtgtgg cACCCCAAtgtgg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N N |
-0.09 -0.182 -0.107 -0.182 -0.064 -0.114 -0.231 -0.125 -0.273 -0.242 -0.09 |
|||
| 113410159 | rs200282737 | C | C |
hsa-miR-342-5p hsa-miR-4466 hsa-miR-4664-5p hsa-miR-675-5p |
0 |
cccGCACCCCgat cCCGCACCccgat cccGCACCCCgat cCCGCACCccgat |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.126 -0.179 -0.126 -0.207 |
| A |
hsa-miR-125b-1-3p |
3 |
cccgcAACCCGAt |
Created |
N |
-0.171 |
|||
| 113410162 | rs190267578 | A | G |
hsa-miR-342-5p hsa-miR-4466 hsa-miR-4664-5p hsa-miR-675-5p |
0 |
cctcccGCACCCC cctcCCGCACCcc cctcccGCACCCC cctcCCGCACCcc |
Created Created Created Created |
N N N N |
-0.126 -0.179 -0.126 -0.207 |
| A |
hsa-miR-1233-5p hsa-miR-1273h-5p hsa-miR-149-3p hsa-miR-30b-3p hsa-miR-3689a-3p hsa-miR-3689b-3p hsa-miR-3689c hsa-miR-4455 hsa-miR-4648 hsa-miR-4654 hsa-miR-4728-5p hsa-miR-4769-5p hsa-miR-6747-5p hsa-miR-6778-5p hsa-miR-6779-5p hsa-miR-6780a-5p hsa-miR-6785-5p hsa-miR-6799-5p hsa-miR-6883-5p hsa-miR-7106-5p |
0 |
cCTCCCACAcccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc cctccCACACCCc ccTCCCACAcccc ccTCCCACAcccc CCTCCCAcacccc ccTCCCACAcccc cctcccACACCCC cCTCCCACAcccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc CCTCCCAcacccc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N N N N N N N N N N N |
-0.192 -0.089 -0.158 -0.098 -0.079 -0.079 -0.079 -0.049 -0.081 -0.088 -0.159 -0.091 -0.119 -0.223 -0.117 -0.079 -0.155 -0.098 -0.158 -0.082 |
|||
| 113410163 | rs199516692 | C | C |
hsa-miR-149-3p hsa-miR-4466 hsa-miR-4728-5p hsa-miR-675-5p hsa-miR-6785-5p hsa-miR-6883-5p |
4 0 4 14 4 4 |
CCCTCCCgcaccc ccctcCCGCACCc CCCTCCCgcaccc ccctcCCGCACCc CCCTCCCgcaccc CCCTCCCgcaccc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.124 -0.179 -0.134 -0.207 -0.106 -0.124 |
| T |
hsa-miR-1286 hsa-miR-4459 hsa-miR-4722-5p hsa-miR-4779 |
0 |
cccTCCTGCAccc cCCTCCTGcaccc ccCTCCTGCAccc CCCTCCTgcaccc |
Created Created Created Created |
N N N N |
-0.065 -0.082 -0.19 -0.136 |
|||
| 113410167 | rs200800026 | C | C |
hsa-miR-149-3p hsa-miR-4300 hsa-miR-4419a hsa-miR-4510 hsa-miR-4728-5p hsa-miR-5591-5p hsa-miR-6127 hsa-miR-6129 hsa-miR-6130 hsa-miR-6133 hsa-miR-6726-5p hsa-miR-6785-5p hsa-miR-6797-5p hsa-miR-6883-5p hsa-miR-920 |
4 3 4 4 4 3 4 4 4 4 3 7 3 4 3 |
agctCCCTCCCgc AGCTCCCtcccgc agCTCCCTCccgc agCTCCCTCccgc agctCCCTCCCgc AGCTCCCtcccgc agCTCCCTCccgc agCTCCCTCccgc agCTCCCTCccgc agCTCCCTCccgc AGCTCCCtcccgc agctCCCTCCCgc agcTCCCTCCcgc agctCCCTCCCgc AGCTCCCtcccgc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N N N N N N |
-0.124 -0.154 -0.056 -0.074 -0.134 -0.173 -0.074 -0.084 -0.074 -0.102 -0.163 -0.106 -0.069 -0.124 -0.163 |
| T |
hsa-miR-28-5p hsa-miR-3139 hsa-miR-4533 hsa-miR-4747-5p hsa-miR-5196-5p hsa-miR-708-5p |
3 3 3 4 4 3 |
AGCTCCTtcccgc AGCTCCTtcccgc agcTCCTTCCcgc agctCCTTCCCgc agctCCTTCCCgc AGCTCCTtcccgc |
Created Created Created Created Created Created |
N N N N N N |
-0.135 -0.126 -0.009 -0.1 -0.109 -0.126 |
|||
| 113410299 | rs199924485 | C | C |
hsa-miR-1909-3p hsa-miR-4455 hsa-miR-6132 hsa-miR-6722-3p hsa-miR-6836-5p |
4 3 8 8 8 |
ttcacaCCCTGCA ttCACACCCtgca ttcacaCCCTGCA ttcacaCCCTGCA ttcacaCCCTGCA |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.106 -0.171 -0.108 -0.106 -0.105 |
| A |
hsa-miR-3611 hsa-miR-3665 hsa-miR-657 |
3 15 6 |
TTCACAAcctgca ttcacaACCTGCA ttcacAACCTGCA |
Created Created Created |
N N N |
No Change -0.072 -0.228 |
|||
| 113410382 | rs200963966 | C | C |
hsa-miR-3155a hsa-miR-3155b hsa-miR-484 hsa-miR-510-5p |
1 1 1 1 |
ctgGAGCCTGAgt ctgGAGCCTGAgt ctgGAGCCTGAgt ctggagCCTGAGT |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.267 -0.267 -0.309 -0.092 |
| T |
hsa-miR-4494 hsa-miR-499b-5p hsa-miR-508-5p |
1 1 2 |
ctggAGTCTGAgt ctggAGTCTGAgt CTGGAGTctgagt |
Created Created Created |
N N N |
-0.053 -0.046 -0.051 |
|||
| 113410472 | rs199666125 | C | C |
hsa-miR-4652-5p hsa-miR-6795-5p hsa-miR-6887-5p |
6 21 21 |
tagAGTCCCCcct tagagTCCCCCCt tagagTCCCCCCt |
Disrupted Disrupted Disrupted |
N N N |
-0.127 -0.249 -0.212 |
| A |
hsa-miR-5684 hsa-miR-6732-5p hsa-miR-6835-5p |
2 2 21 |
TAGAGTAccccct tagagtACCCCCT tagagTACCCCCt |
Created Created Created |
N N N |
-0.032 -0.204 -0.168 |
|||
| 113410562 | rs201700158 | - | C |
hsa-miR-147b hsa-miR-4455 hsa-miR-6804-5p |
2 9 10 |
cCCGCACAccctc cccgCACACCCtc cccgcaCACCCTC |
Unknown Unknown Unknown |
N N N |
-0.185 -0.111 -0.246 |
| 113410610 | rs200147005 | - | G |
hsa-miR-4763-5p |
6 |
caccccGGCAGGC |
Unknown |
N |
-0.12 |
| A |
hsa-miR-342-5p hsa-miR-3692-5p hsa-miR-370-3p hsa-miR-4651 hsa-miR-4664-5p hsa-miR-4731-5p hsa-miR-5589-5p hsa-miR-608 hsa-miR-6737-5p hsa-miR-6747-5p hsa-miR-6812-5p hsa-miR-6819-5p hsa-miR-6893-3p hsa-miR-7155-5p |
3 8 8 3 3 4 5 3 3 3 3 3 8 3 |
CACCCCAgcaggc caccCCAGCAGgc cacccCAGCAGGc CACCCCAgcaggc CACCCCAgcaggc caCCCCAGCAggc cacCCCAGCAggc CACCCCAgcaggc CACCCCAgcaggc CACCCCAgcaggc CACCCCAgcaggc CACCCCAgcaggc cacccCAGCAGGc cACCCCAGcaggc |
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown |
N N N N N N N N N N N N N N |
-0.141 -0.107 -0.105 -0.134 -0.147 -0.38 -0.12 -0.134 -0.19 -0.159 -0.208 -0.19 -0.068 -0.156 |
|||
| 113410617 | rs201110531 | - | T |
hsa-miR-4709-3p |
2 |
tcCTCTTCAcccc |
Unknown |
N |
0.004 |
| C |
hsa-miR-185-5p hsa-miR-363-5p hsa-miR-4306 hsa-miR-4644 hsa-miR-4651 hsa-miR-5192 hsa-miR-608 hsa-miR-6745 hsa-miR-6880-5p |
2 3 2 2 3 2 3 3 3 |
tcCTCTCCAcccc tcctcTCCACCCc tcCTCTCCAcccc tcCTCTCCAcccc tcctctCCACCCC tcCTCTCCAcccc tcctctCCACCCC tcctcTCCACCCc tcctCTCCACCcc |
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown |
N N N N N N N N N |
-0.069 -0.102 -0.069 -0.066 -0.189 -0.09 -0.189 -0.112 -0.153 |
|||
| 113410690 | rs9282673 | C | C |
hsa-miR-1321 hsa-miR-3689d hsa-miR-4270 hsa-miR-4441 hsa-miR-4739 hsa-miR-4756-5p hsa-miR-6134 hsa-miR-6754-5p hsa-miR-6799-5p hsa-miR-6851-5p |
11 6 10 10 11 11 6 10 4 6 |
tcccaCCTCCCTg tccCACCTCCctg tcccacCTCCCTG tcccacCTCCCTG tcccaCCTCCCTg tcccaCCTCCCTg tcCCACCTCcctg tcccacCTCCCTG tcccACCTCCCtg tccCACCTCCctg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N |
-0.118 -0.109 -0.12 -0.064 -0.137 -0.127 -0.09 -0.082 -0.12 -0.128 |
| A |
hsa-miR-1233-5p hsa-miR-299-3p hsa-miR-4648 hsa-miR-4654 hsa-miR-4764-5p hsa-miR-4769-5p hsa-miR-6757-5p hsa-miR-6778-5p |
4 4 4 4 6 4 10 4 |
TCCCACAtccctg tCCCACATccctg TCCCACAtccctg TCCCACAtccctg tccCACATCCctg TCCCACAtccctg tcccaCATCCCTg TCCCACAtccctg |
Created Created Created Created Created Created Created Created |
N N N N N N N N |
-0.125 -0.129 -0.137 -0.151 -0.086 -0.137 -0.13 -0.125 |