SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000794
Gene Symbol: DRD1
Description: Homo sapiens dopamine receptor D1 (DRD1), mRNA.
Gene Location: chr5(-):174867674-174871163
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr5:g.175440719T>C COSN8492353 J73_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-944 taaAATAATTggccctctc
 12
 AAAUUAUU m7b (m7b->m6c) -0.039000 no TS 1.180000

Mutation Mutation ID Sample Name Cancer Type
chr5:g.175440741C>T COSN1312295 HX13T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103a-3p tatATGCTGCTttgtattt
 1
 AGCAGCAU m8a Disrupted -0.308000 no TS 0.470000
hsa-miR-107 tatATGCTGCTttgtattt
 1
 AGCAGCAU m8a Disrupted -0.308000 no TS 1.110000
hsa-miR-15a-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.449000 -0.150000 1.450000
hsa-miR-15b-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.458000 -0.150000 1.220000
hsa-miR-16-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.449000 -0.141000 1.670000
hsa-miR-195-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.449000 -0.141000 0.510000
hsa-miR-330-3p tatatgcTGCTTTGtattt
 2
 GCAAAGCA m7b Disrupted -0.174000 no TS 1.400000
hsa-miR-424-5p tataTGCTGCTttgtattt
 0 CAGCAGCA m7b Disrupted -0.468000 -0.150000 No effect
hsa-miR-497-5p tataTGCTGCTttgtattt
 0 CAGCAGCA m7b Disrupted -0.449000 -0.150000 0.340000
hsa-miR-520d-5p tatatgctgCTTTGTAttt
 12
 CUACAAAG m7b (m7b->m6b) -0.116000 no TS 1.530000
hsa-miR-524-5p tatatgctgCTTTGTAttt
 12
 CUACAAAG m7b (m7b->m6b) -0.134000 no TS 1.530000
hsa-miR-103a-3p tatATGCTGCTttgtattt
 0 AGCAGCAU m8a Disrupted -0.308 no TS 0.47
hsa-miR-107 tatATGCTGCTttgtattt
 0 AGCAGCAU m8a Disrupted -0.308 no TS 1.11
hsa-miR-15a-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.449 -0.15 1.45
hsa-miR-15b-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.458 -0.15 1.22
hsa-miR-16-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.449 -0.141 1.67
hsa-miR-195-5p tataTGCTGCTttgtattt
 0 UAGCAGCA m7b Disrupted -0.449 -0.141 0.51
hsa-miR-330-3p tatatgcTGCTTTGtattt
 0 GCAAAGCA m7b Disrupted -0.174 no TS 1.4
hsa-miR-424-5p tataTGCTGCTttgtattt
 0 CAGCAGCA m7b Disrupted -0.468 -0.15 No effect
hsa-miR-497-5p tataTGCTGCTttgtattt
 0 CAGCAGCA m7b Disrupted -0.449 -0.15 0.34
hsa-miR-520d-5p tatatgctgCTTTGTAttt
 0 CUACAAAG m7b (m7b->m6b) -0.116 no TS 1.53
hsa-miR-524-5p tatatgctgCTTTGTAttt
 0 CUACAAAG m7b (m7b->m6b) -0.134 no TS 1.53

Mutation Mutation ID Sample Name Cancer Type
chr5:g.175441553A>G COSN1312296 HCC2T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-142-3p agggACACTACAaacatgg
 1
 UGUAGUGU m8a Disrupted -0.292000 no TS 0.150000
hsa-miR-3674 agggacaCTACAAacatgg
 1
 AUUGUAGA m6b Disrupted -0.036000 no TS 7.500000
hsa-miR-557 agggacacTGCAAACatgg
 0 GUUUGCAC m7a Created NA NA -11.110000
hsa-miR-142-3p agggACACTACAaacatgg
 0 UGUAGUGU m8a Disrupted -0.292 no TS 0.15
hsa-miR-3674 agggacaCTACAAacatgg
 0 AUUGUAGA m6b Disrupted -0.036 no TS 7.5
hsa-miR-557 agggacacTGCAAACatgg
 0 GUUUGCAC m7a Created NA NA -11.11

Mutation Mutation ID Sample Name Cancer Type
chr5:g.175441697C>T COSN14792914 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4323 gctcTGGGGCTtgctatta
 0 CAGCCCCA m7b Disrupted -0.254000 no TS 2.620000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
175440746 rs116555419 T T hsa-miR-103a-3p
hsa-miR-107
hsa-miR-15a-5p
hsa-miR-15b-5p
hsa-miR-16-5p
hsa-miR-195-5p
hsa-miR-424-5p
hsa-miR-497-5p
hsa-miR-6838-5p
1
1
1
1
1
1
1
1
1
 agtatATGCTGCt
agtatATGCTGCt
agtataTGCTGCT
agtataTGCTGCT
agtataTGCTGCT
agtataTGCTGCT
agtataTGCTGCT
agtataTGCTGCT
agtataTGCTGCT
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 -0.308
-0.308
-0.299
-0.308
-0.308
-0.308
-0.318
-0.299
-0.29
C hsa-miR-503-5p
1
 agtataCGCTGCT
 Created
N
 -0.362
175441696 rs1799961 T T hsa-miR-4323
hsa-miR-451b
4
21
 TGGGGCTtgctat
tggggCTTGCTAt
 Disrupted
Disrupted
N
N
 -0.254
-0.11
C hsa-miR-4690-5p
hsa-miR-6165
hsa-miR-6510-5p
hsa-miR-874-5p
12
21
21
4
 tgggGCCTGCTAt
tggggCCTGCTAt
tggggCCTGCTAt
TGGGGCCtgctat
 Created
Created
Created
Created
N
N
N
N
 -0.416
-0.159
-0.165
-0.271
175441697 rs686 C C hsa-miR-4323
hsa-miR-451b
4
21
 cTGGGGCTtgcta
ctggggCTTGCTA
 Disrupted
Disrupted
N
N
 -0.254
-0.11
T hsa-miR-548p
hsa-miR-6771-3p
21
4
 ctggggTTTGCTA
ctGGGGTTTgcta
 Created
Created
N
N
 -0.056
-0.189

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