SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_018662
Gene Symbol: DISC1
Description: Homo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant Lv, mRNA.
Gene Location: chr1(+):231762560-232177019
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.232037208G>A COSN6026767 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4684-3p tgcTGCAACAaaaatattt
 0 UGUUGCAA m7a (m6a->m7a) no TS -0.129000 -0.100000
hsa-miR-744-3p tgctGCAACAaaaatattt
 0 CUGUUGCC m6b Created no TS -0.106000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038383A>G COSN8447943 AOCS-055-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3667-3p cactgAGGAAGGTggcccc
 0 ACCUUCCU m8a Disrupted -0.057000 -0.148000 0.050000
hsa-miR-4667-3p cactgAGGAGGGtggcccc
 1
 UCCCUCCU m7b Created -0.197000 -0.148000 -0.090000
hsa-miR-5193 cactGAGGAGGgtggcccc
 0 UCCUCCUC m7b Created no TS 0.014000 -1.320000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038465T>C COSN15447231 AOCS-150-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4678 accatAATACCTgcttgga
 0 AAGGUAUU m7b Created no TS 0.063000 -0.050000
hsa-miR-656 accATAATATctgcttgga
 2
 AAUAUUAU m7b (m7b->m6b) 0.242000 no TS 0.010000
hsa-miR-4678 accatAATACCTgcttgga
 0 AAGGUAUU m7b Created no TS 0.063000 -0.050000
hsa-miR-656 accATAATATctgcttgga
 2
 AAUAUUAU m7b (m7b->m6b) 0.242000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038484T>C COSN1435640 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-210 gaaccacaACGCACAttag
 0 CUGUGCGU m7b Created no TS -0.113000 -2.020000
hsa-miR-33a-5p gaaccaCAATGCACattag
 0 GUGCAUUG m8a Disrupted 0.122000 0.099000 No effect
hsa-miR-33b-5p gaaccaCAATGCACattag
 0 GUGCAUUG m8a Disrupted 0.122000 0.099000 No effect
hsa-miR-4289 gaacCACAATGCacattag
 0 GCAUUGUG m8a Disrupted 0.064000 no TS 0.080000
hsa-miR-210 gaaccacaACGCACAttag
 0 CUGUGCGU m7b Created no TS -0.113 -2.02
hsa-miR-33a-5p gaaccaCAATGCACattag
 0 GUGCAUUG m8a Disrupted 0.122 0.099 No effect
hsa-miR-33b-5p gaaccaCAATGCACattag
 0 GUGCAUUG m8a Disrupted 0.122 0.099 9.5
hsa-miR-4289 gaacCACAATGCacattag
 0 GCAUUGUG m8a Disrupted 0.064 no TS 0.08

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038595T>C COSN8447945 AOCS-166-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4653-3p tcatgTAACTCCtattcat
 2
 UGGAGUUA m7b Disrupted -0.018000 no TS 4.390000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232039572C>T cosmic_v64_1732875 Medulloblastoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374b-3p cagaaagtCTGCTAAGggc
 0 CUUAGCAG m8a Created no TS 0.085 -0.03
hsa-miR-4524a-5p cagaaagtCTGCTAagggc
 0 AUAGCAGC m6b Created no TS 0.047 No effect
hsa-miR-4524b-5p cagaaagtCTGCTAagggc
 0 AUAGCAGC m6b Created no TS 0.047 No effect
hsa-miR-4771 cagaaAGTCTGCTaagggc
 0 AGCAGACU m8a Created -0.376 -0.43 -3.07
hsa-miR-499b-5p cagaAAGTCTGctaagggc
 0 ACAGACUU m7b Created 0.008 0.008 -5.77

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232039676T>A COSN15357021 AOCS-034-3-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4307 tatcctcAAACATactata
 0 AAUGUUUU m6b Created no TS 0.166000 0.040000
hsa-miR-4461 tatcCTCAATCatactata
 1
 GAUUGAGA m7a Disrupted 0.067000 0.067000 0.020000
hsa-miR-567 tatcctcaAACATACTata
 0 AGUAUGUU m8a Created no TS 0.027000 0.210000
hsa-miR-4307 tatcctcAAACATactata
 0 AAUGUUUU m6b Created no TS 0.166000 0.040000
hsa-miR-4461 tatcCTCAATCatactata
 1
 GAUUGAGA m7a Disrupted 0.067000 0.067000 0.020000
hsa-miR-567 tatcctcaAACATACTata
 0 AGUAUGUU m8a Created no TS 0.027000 0.210000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040101A>C ICGC_6DBE8FCC-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-5p agctattctACTGCCTcag
 0 CAGGCAGU m7b (m7b->m6c) -0.137 -0.101 No effect
hsa-miR-34b-5p agctattctACTGCCTcag
 0 UAGGCAGU m7b (m7b->m6c) -0.212 -0.129 0.06
hsa-miR-449c-5p agctattctACTGCCTcag
 0 UAGGCAGU m7b (m7b->m6c) -0.175 -0.111 No effect
hsa-miR-4722-5p agctattCTCCTGCCtcag
 0 GGCAGGAG m8a Created 0.031 -0.029 -2.48
hsa-miR-4768-3p agctatTCTCCTGcctcag
 0 CCAGGAGA m7b Created -0.163 -0.16 -0.04
hsa-miR-936 agctatTCTACTGcctcag
 1
 ACAGUAGA m7b Disrupted -0.021 no TS 1.5
hsa-miR-940 agctattctCCTGCCTcag
 0 AAGGCAGG m7b (m6c->m7b) -0.037 -0.091 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040185C>T ICGC_6DBE949A-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10a-5p gagACAGGGTttcaccatg
 0 UACCCUGU m7b (m6b->m7b) no TS -0.078 -0.93
hsa-miR-10b-5p gagACAGGGTttcaccatg
 0 UACCCUGU m7b (m6b->m7b) no TS -0.078 -0.24
hsa-miR-146b-3p gagACAGGGCttcaccatg
 0 UGCCCUGU m7b (m7b->m6b) -0.228 -0.12 0.01

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040263A>G ICGC_6DBE9968-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-216a aaagtgcTGAGATTAcagg
 2
 UAAUCUCA m8a Disrupted -0.011 -0.097 1.73
hsa-miR-216b aaagtgctGAGATTacagg
 0 AAAUCUCU m6b Disrupted 0.075 no TS 0.03
hsa-miR-4530 aaagTGCTGGGattacagg
 0 CCCAGCAG m7a Created 0.066 0.066 -0.13
hsa-miR-4733-5p aaagtgcTGGGATTacagg
 0 AAUCCCAA m7a Created NA NA -2.02

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040629C>T COSN9061533 C0065T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p cctaaagtTTCTTTaatgt
 0 CAAAGAAU m6b Created no TS 0.057000 -0.010000
hsa-miR-3133 cctaaagtTTCTTTAatgt
 2
 UAAAGAAC m7a Created 0.166000 0.224000 -0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
232036851 rs112807868 G G hsa-miR-1470
hsa-miR-4469
hsa-miR-4667-3p
1
1
1
 gggGGAGGGAggt
ggggGAGGGAGgt
gggGGAGGGAggt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.136
-0.098
-0.133
232037446 rs142965400 T T hsa-miR-488-3p
hsa-miR-5681a
hsa-miR-6730-5p
3
3
2
 ccaCCTTTCAAtt
ccaCCTTTCAatt
ccACCTTTCAatt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.167
-0.036
-0.117
C hsa-miR-4461
hsa-miR-6134
2
2
 ccaccTCTCAATt
CCACCTCtcaatt
 Created
Created
N
N
 -0.03
-0.161
232037464 rs139283763 G G hsa-miR-3064-3p
hsa-miR-4317
hsa-miR-4715-3p
5
2
5
 ttTGTGGCAAtga
tttgtGGCAATGA
tttGTGGCAAtga
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.332
-0.3
-0.128
A hsa-miR-4289
hsa-miR-4719
3
3
 tttgtgACAATGA
TTTGTGAcaatga
 Created
Created
N
N
 -0.027
0.022
232038286 rs199803540 G G hsa-miR-214-3p
hsa-miR-3619-5p
hsa-miR-4530
hsa-miR-4722-5p
hsa-miR-6165
hsa-miR-761
3
3
3
3
3
3
 gctCCTGCTGggc
gctCCTGCTGggc
gctcCTGCTGGgc
gCTCCTGCtgggc
gcTCCTGCTgggc
gctCCTGCTGggc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.046
0.027
0.061
0.031
0.095
0.027
A hsa-miR-28-5p
hsa-miR-3139
hsa-miR-708-5p
3
3
3
 GCTCCTActgggc
GCTCCTActgggc
GCTCCTActgggc
 Created
Created
Created
N
N
N
 -0.004
-0.017
-0.01
232038307 rs9661748 A A hsa-miR-1207-3p
hsa-miR-4640-5p
hsa-miR-4726-5p
hsa-miR-6508-3p
3
3
3
3
 tggcCCAGCTGgg
TGGCCCAgctggg
TGGCCCAgctggg
TGGCCCAgctggg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 0.071
-0.042
-0.028
-0.031
T hsa-miR-214-3p
hsa-miR-3619-5p
hsa-miR-3918
hsa-miR-4530
hsa-miR-6132
hsa-miR-6510-5p
hsa-miR-6836-5p
hsa-miR-6895-5p
hsa-miR-761
3
3
3
5
3
3
3
3
3
 tggcCCTGCTGgg
tggcCCTGCTGgg
tGGCCCTGctggg
tggccCTGCTGGg
tgGCCCTGCtggg
tggCCCTGCTggg
tgGCCCTGCtggg
TGGCCCTgctggg
tggcCCTGCTGgg
 Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
 0.069
0.069
-0.065
0.066
-0.027
0.025
-0.046
-0.063
0.069
232039402 rs151172119 C C hsa-miR-2682-5p
hsa-miR-34b-5p
hsa-miR-3714
hsa-miR-3922-5p
hsa-miR-449c-5p
hsa-miR-548au-3p
hsa-miR-561-5p
2
2
2
2
2
2
5
 taACTGCCTtgaa
taACTGCCTtgaa
taaCTGCCTTgaa
taactGCCTTGAa
taACTGCCTtgaa
tAACTGCCttgaa
taactgCCTTGAA
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.101
-0.129
-0.06
-0.026
-0.111
-0.148
-0.008
232040106 rs191369449 C C hsa-miR-1827
hsa-miR-2682-5p
hsa-miR-34b-5p
hsa-miR-449c-5p
hsa-miR-4649-3p
hsa-miR-7160-5p
1
1
1
1
2
2
 taCTGCCTCAgcc
tACTGCCTcagcc
tACTGCCTcagcc
tACTGCCTcagcc
tactGCCTCAGcc
tactgCCTCAGCc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.118
-0.036
-0.083
-0.064
-0.018
-0.001
232041152 rs192765612 C C hsa-miR-8080
2
 tttTGTCCTTtga
 Disrupted
N
 -0.256
T hsa-miR-3133
2
 ttttGTTCTTTga
 Created
N
 -0.17

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