SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001164556
Gene Symbol:	DISC1
Description:	Homo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant Lv, mRNA.
Gene Location:	chr1(+):231762560-231954990
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.231818549T>C			COSN1435560		RK001_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-16-2-3p	ccggcaagATATTGatgat	1	CCAAUAUU	m6b	Disrupted	-0.004000	no TS	4.300000
hsa-miR-195-3p	ccggcaagATATTGatgat	1	CCAAUAUU	m6b	Disrupted	-0.001000	no TS	7.790000
hsa-miR-431-5p	ccgGCAAGACAttgatgat	0	UGUCUUGC	m8a	Created	no TS	-0.298000	-1.710000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.231819192C>T			COSN14564589		8064157		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3143	aataAATGTTATttactaa	0	AUAACAUU	m8a	Created	no TS	-0.184000	-0.020000
hsa-miR-3646	aataaatgTCATTTactaa	1	AAAAUGAA	m6b	Disrupted	-0.037000	no TS	0.330000
hsa-miR-543	aataAATGTTatttactaa	1	AAACAUUC	m6b	Created	-0.046000	-0.113000	-0.380000
hsa-miR-5692a	aataaatgTTATTTactaa	7	CAAAUAAU	m6b	Created	0.087000	0.112000	-2.580000
hsa-miR-3143	aataAATGTTATttactaa	0	AUAACAUU	m8a	Created	no TS	-0.184000	-0.020000
hsa-miR-3646	aataaatgTCATTTactaa	1	AAAAUGAA	m6b	Disrupted	-0.037000	no TS	0.330000
hsa-miR-543	aataAATGTTatttactaa	1	AAACAUUC	m6b	Created	-0.046000	-0.113000	-0.380000
hsa-miR-5692a	aataaatgTTATTTactaa	7	CAAAUAAU	m6b	Created	0.087000	0.112000	-2.580000
hsa-miR-3143	aataAATGTTATttactaa	0	AUAACAUU	m8a	Created	no TS	-0.184000	-0.020000
hsa-miR-3646	aataaatgTCATTTactaa	1	AAAAUGAA	m6b	Disrupted	-0.037000	no TS	0.330000
hsa-miR-543	aataAATGTTatttactaa	1	AAACAUUC	m6b	Created	-0.046000	-0.113000	-0.380000
hsa-miR-5692a	aataaatgTTATTTactaa	7	CAAAUAAU	m6b	Created	0.087000	0.112000	-2.580000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
231818845	rs199603966	C
			A	hsa-miR-3646 hsa-miR-3662 hsa-miR-4698 hsa-miR-4699-5p	8 7 8 5	atcTTCATTTtgt atctTCATTTTgt atcttCATTTTGt ATCTTCAttttgt	Created Created Created Created	N N N N	0.047 0.029 -0.015 -0.063

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