SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001164541
Gene Symbol:	DISC1
Description:	Homo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant Lv, mRNA.
Gene Location:	chr1(+):231762560-232145400
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.232009067G>A			COSN519655		TCGA-F4-6807-01		[large_intestine][colon][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-15a-3p	ttttcacATGGCCTccaga	0	CAGGCCAU	m7b	Disrupted	-0.154000	no TS	0.010000
hsa-miR-3607-5p	tttTCACATGgcctccaga	0	GCAUGUGA	m7b	(m7b->m6b)	-0.124000	no TS	3.770000
hsa-miR-3975	ttttcacaTAGCCTCcaga	0	UGAGGCUA	m7b	Created	no TS	-0.170000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.232009072C>T			COSN8309066		TCGA-LL-A441-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-146a-3p	acatggccTTCAGAGGgga	0	CCUCUGAA	m8a	Created	no TS	-0.025000	-1.790000
hsa-miR-3612	acatgGCCTCCagagggga	0	AGGAGGCA	m6b	Disrupted	-0.175000	no TS	0.530000
hsa-miR-4443	acatgGCCTCCAgagggga	0	UUGGAGGC	m7b	Disrupted	-0.187000	no TS	0.290000
hsa-miR-4493	acatGGCCTTCagagggga	0	AGAAGGCC	m7b	Created	no TS	-0.387000	0.030000
hsa-miR-4753-5p	acaTGGCCTTcagagggga	0	CAAGGCCA	m7b	(m6b->m7b)	no TS	-0.209000	No effect
hsa-miR-516b-5p	acatggcCTCCAGAgggga	0	AUCUGGAG	m7b	Disrupted	-0.087000	no TS	0.310000
hsa-miR-518c-5p	acatggccTCCAGAGggga	0	UCUCUGGA	m7b	Disrupted	-0.066000	no TS	0.520000
hsa-miR-650	acatgGCCTCCagagggga	0	AGGAGGCA	m6b	Disrupted	-0.171000	no TS	4.270000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.232009082C>A			COSN5738716		HCC154		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.232009435G>A			COSN6447216		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1277-5p	atacattATATATTgtatg	2	AAAUAUAU	m7b	Created	-0.474000	-0.578000	0.040000
hsa-miR-338-5p	atacattatATATTGTatg	0	AACAAUAU	m7b	(m6c->m7b)	-0.063000	-0.231000	0.020000
hsa-miR-374b-5p	atacATTATATattgtatg	0	AUAUAAUA	m7a	Created	-0.078000	-0.078000	0.090000
hsa-miR-5011-5p	atacatTATATATtgtatg	3	UAUAUAUA	m7b	Created	-0.236000	-0.323000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
232009338	rs148677963	T	T	hsa-miR-190a-3p hsa-miR-3146 hsa-miR-5011-5p	7 10 7	cATATATAgcata catataTAGCATA cATATATAgcata	Disrupted Disrupted Disrupted	N N N	0.001 -0.142 0.045
			C	hsa-miR-1537-5p hsa-miR-4718 hsa-miR-4728-3p hsa-miR-4999-5p	7 9 10 8	cataTACAGCAta cataTACAGCAta catataCAGCATA catATACAGCAta	Created Created Created Created	N N N N	-0.165 -0.175 -0.139 -0.411
232009376	rs144211779	A	A	hsa-miR-369-3p hsa-miR-374a-5p hsa-miR-374b-5p hsa-miR-5692b hsa-miR-5692c	21 21 21 21 21	gtTATTATAttca gtTATTATAttca gtTATTATAttca gtTATTATAttca gtTATTATAttca	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	No Change -0.087 -0.078 0.007 0.007
			G	hsa-miR-338-5p hsa-miR-4666a-3p	21 21	gtTATTGTAttca gttATTGTATtca	Created Created	N N	-0.035 -0.119
232009435	rs821618	A
			A	hsa-miR-1277-5p hsa-miR-338-5p hsa-miR-410-3p hsa-miR-5011-5p	0	cattATATATTgt cattatATATTGT caTTATATAttgt catTATATATtgt	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.104 -0.168 -0.002 -0.087
232009437	rs111511155	A	A	hsa-miR-338-5p hsa-miR-4666a-3p	0	ttatgTATTGTAt ttatgtATTGTAT	Disrupted Disrupted	N N	-0.063 -0.159
			G	hsa-miR-3529-3p hsa-miR-4789-3p	0	ttatgTGTTGTAt tTATGTGTtgtat	Created Created	N N	-0.114 -0.232
232009459	rs111846808	-	-	hsa-miR-410-3p hsa-miR-5011-5p	1 7	tatgatgtTTATATAttta tatgatgttTATATATtta	Unknown Unknown	N N	0.017 0.02
			AATT
232009460	rs201452489	-	-	hsa-miR-1277-5p hsa-miR-410-3p hsa-miR-5011-5p	7 1 7	atgatgtttATATATTtag atgatgtTTATATAtttag atgatgttTATATATttag	Unknown Unknown Unknown	N N N	-0.021 0.017 0.02
			ATTA
232009461	rs201442383	T	T	hsa-miR-1277-5p hsa-miR-410-3p hsa-miR-5011-5p	7 1 7	tgtttATATATTt tgtTTATATAttt tgttTATATATtt	Disrupted Disrupted Disrupted	N N N	-0.135 -0.007 -0.123
232009461	rs67970482	-	-	hsa-miR-1277-5p hsa-miR-410-3p hsa-miR-5011-5p	7 1 7	tgatgtttATATATTtaga tgatgtTTATATAtttaga tgatgttTATATATttaga	Unknown Unknown Unknown	N N N	-0.136 -0.008 -0.124
			CTTA	hsa-miR-4662a-3p hsa-miR-577	7 1	tgatgttTATCTTAatatttaga tgatgTTTATCTtaatatttaga	Unknown Unknown	N N	-0.09 -0.119
232009475	rs1772690	A	A	hsa-miR-1277-5p hsa-miR-376a-5p hsa-miR-5011-5p	5 5 3	gaatctATATATT GAATCTAtatatt gaatcTATATATt	Disrupted Disrupted Disrupted	N N N	-0.162 -0.28 -0.071
			G	hsa-let-7f-2-3p hsa-miR-10b-3p hsa-miR-1185-1-3p hsa-miR-1185-2-3p hsa-miR-5683	4 5 4 4 5	gaatCTGTATAtt GAATCTGtatatt gaatCTGTATAtt gaatCTGTATAtt gaATCTGTAtatt	Created Created Created Created Created	N N N N N	-0.228 -0.284 -0.219 -0.21 -0.12
232009476	rs1754593	T	T	hsa-miR-1277-5p hsa-miR-5011-5p	4 3	aatctATATATTA aatcTATATATta	Disrupted Disrupted	N N	-0.128 -0.071
			C	hsa-miR-3668 hsa-miR-376a-2-5p hsa-miR-3935 hsa-miR-4517 hsa-miR-5583-3p hsa-miR-7852-3p	4 5 5 10 5 4	aaTCTACATAtta AATCTACAtatta aATCTACAtatta aatctaCATATTA aatctaCATATTA aatCTACATAtta	Created Created Created Created Created Created	N N N N N N	-0.398 -0.349 -0.15 -0.053 -0.069 -0.162

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