SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001012959
Gene Symbol:	DISC1
Description:	Homo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant Lv, mRNA.
Gene Location:	chr1(+):231762560-232002452
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.231866646A>G			COSN15314911		SNUH_G76_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1244	cagcgctcAACTACTatta	3	AAGUAGUU	m7b	Disrupted	-0.264000	no TS	2.180000
hsa-miR-4663	cagcGCTCAGCTactatta	0	AGCUGAGC	m8a	Created	no TS	-0.228000	-1.540000
hsa-miR-4703-3p	cagcgctCAACTACtatta	3	UGUAGUUG	m7b	Disrupted	-0.182000	no TS	2.280000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
231866646	rs3082	A	A	hsa-miR-1244 hsa-miR-4703-3p hsa-miR-5708	3 3 2	cgctcAACTACTA cgctCAACTACta CGCTCAActacta	Disrupted Disrupted Disrupted	N N N	-0.264 -0.182 -0.25
			G	hsa-miR-4663	2	cGCTCAGCtacta	Created	N	-0.228

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