SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_001012957 |
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Gene Symbol: | DISC1 |
Description: | Homo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant Lv, mRNA. |
Gene Location: | chr1(+):231762560-232177019 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232037208G>A | COSN6026767 | RK308_C01 | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4684-3p |
tgcTGCAACAaaaatattt |
0 | UGUUGCAA | m7a | (m6a->m7a) | no TS | -0.129000 |
-0.100000 |
hsa-miR-744-3p |
tgctGCAACAaaaatattt |
0 | CUGUUGCC | m6b | Created | no TS | -0.106000 |
-0.040000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232038383A>G | COSN8447943 | AOCS-055-1-7 | [ovary][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-3667-3p |
cactgAGGAAGGTggcccc |
0 | ACCUUCCU | m8a | Disrupted | -0.057000 | -0.148000 |
0.050000 |
hsa-miR-4667-3p |
cactgAGGAGGGtggcccc |
1 |
UCCCUCCU | m7b | Created | -0.197000 | -0.148000 |
-0.090000 |
hsa-miR-5193 |
cactGAGGAGGgtggcccc |
0 | UCCUCCUC | m7b | Created | no TS | 0.014000 |
-1.320000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232038465T>C | COSN15447231 | AOCS-150-8-X | [ovary][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4678 |
accatAATACCTgcttgga |
0 | AAGGUAUU | m7b | Created | no TS | 0.063000 |
-0.050000 |
hsa-miR-656 |
accATAATATctgcttgga |
2 |
AAUAUUAU | m7b | (m7b->m6b) | 0.242000 | no TS |
0.010000 |
hsa-miR-4678 |
accatAATACCTgcttgga |
0 | AAGGUAUU | m7b | Created | no TS | 0.063000 |
-0.050000 |
hsa-miR-656 |
accATAATATctgcttgga |
2 |
AAUAUUAU | m7b | (m7b->m6b) | 0.242000 | no TS |
0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232038484T>C | COSN1435640 | RK027_C01 | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-210 |
gaaccacaACGCACAttag |
0 | CUGUGCGU | m7b | Created | no TS | -0.113000 |
-2.020000 |
hsa-miR-33a-5p |
gaaccaCAATGCACattag |
0 | GUGCAUUG | m8a | Disrupted | 0.122000 | 0.099000 | No effect |
hsa-miR-33b-5p |
gaaccaCAATGCACattag |
0 | GUGCAUUG | m8a | Disrupted | 0.122000 | 0.099000 | No effect |
hsa-miR-4289 |
gaacCACAATGCacattag |
0 | GCAUUGUG | m8a | Disrupted | 0.064000 | no TS |
0.080000 |
hsa-miR-210 |
gaaccacaACGCACAttag |
0 | CUGUGCGU | m7b | Created | no TS | -0.113 |
-2.02 |
hsa-miR-33a-5p |
gaaccaCAATGCACattag |
0 | GUGCAUUG | m8a | Disrupted | 0.122 | 0.099 |
-9.49 |
hsa-miR-33b-5p |
gaaccaCAATGCACattag |
0 | GUGCAUUG | m8a | Disrupted | 0.122 | 0.099 |
9.5 |
hsa-miR-4289 |
gaacCACAATGCacattag |
0 | GCAUUGUG | m8a | Disrupted | 0.064 | no TS |
0.08 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232038595T>C | COSN8447945 | AOCS-166-1-2 | [ovary][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4653-3p |
tcatgTAACTCCtattcat |
2 |
UGGAGUUA | m7b | Disrupted | -0.018000 | no TS |
4.390000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232039572C>T | cosmic_v64_1732875 | Medulloblastoma | ||||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-374b-3p |
cagaaagtCTGCTAAGggc |
0 | CUUAGCAG | m8a | Created | no TS | 0.085 |
-0.03 |
hsa-miR-4524a-5p |
cagaaagtCTGCTAagggc |
0 | AUAGCAGC | m6b | Created | no TS | 0.047 | No effect |
hsa-miR-4524b-5p |
cagaaagtCTGCTAagggc |
0 | AUAGCAGC | m6b | Created | no TS | 0.047 | No effect |
hsa-miR-4771 |
cagaaAGTCTGCTaagggc |
0 | AGCAGACU | m8a | Created | -0.376 | -0.43 |
-3.07 |
hsa-miR-499b-5p |
cagaAAGTCTGctaagggc |
0 | ACAGACUU | m7b | Created | 0.008 | 0.008 |
-5.77 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232039676T>A | COSN15357021 | AOCS-034-3-8 | [ovary][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4307 |
tatcctcAAACATactata |
0 | AAUGUUUU | m6b | Created | no TS | 0.166000 |
0.040000 |
hsa-miR-4461 |
tatcCTCAATCatactata |
1 |
GAUUGAGA | m7a | Disrupted | 0.067000 | 0.067000 |
0.020000 |
hsa-miR-567 |
tatcctcaAACATACTata |
0 | AGUAUGUU | m8a | Created | no TS | 0.027000 |
0.210000 |
hsa-miR-4307 |
tatcctcAAACATactata |
0 | AAUGUUUU | m6b | Created | no TS | 0.166000 |
0.040000 |
hsa-miR-4461 |
tatcCTCAATCatactata |
1 |
GAUUGAGA | m7a | Disrupted | 0.067000 | 0.067000 |
0.020000 |
hsa-miR-567 |
tatcctcaAACATACTata |
0 | AGUAUGUU | m8a | Created | no TS | 0.027000 |
0.210000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232040101A>C | ICGC_6DBE8FCC-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-2682-5p |
agctattctACTGCCTcag |
0 | CAGGCAGU | m7b | (m7b->m6c) | -0.137 | -0.101 | No effect |
hsa-miR-34b-5p |
agctattctACTGCCTcag |
0 | UAGGCAGU | m7b | (m7b->m6c) | -0.212 | -0.129 |
0.06 |
hsa-miR-449c-5p |
agctattctACTGCCTcag |
0 | UAGGCAGU | m7b | (m7b->m6c) | -0.175 | -0.111 | No effect |
hsa-miR-4722-5p |
agctattCTCCTGCCtcag |
0 | GGCAGGAG | m8a | Created | 0.031 | -0.029 |
-2.48 |
hsa-miR-4768-3p |
agctatTCTCCTGcctcag |
0 | CCAGGAGA | m7b | Created | -0.163 | -0.16 |
-0.04 |
hsa-miR-936 |
agctatTCTACTGcctcag |
1 |
ACAGUAGA | m7b | Disrupted | -0.021 | no TS |
1.5 |
hsa-miR-940 |
agctattctCCTGCCTcag |
0 | AAGGCAGG | m7b | (m6c->m7b) | -0.037 | -0.091 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232040185C>T | ICGC_6DBE949A-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-10a-5p |
gagACAGGGTttcaccatg |
0 | UACCCUGU | m7b | (m6b->m7b) | no TS | -0.078 |
-0.93 |
hsa-miR-10b-5p |
gagACAGGGTttcaccatg |
0 | UACCCUGU | m7b | (m6b->m7b) | no TS | -0.078 |
-0.24 |
hsa-miR-146b-3p |
gagACAGGGCttcaccatg |
0 | UGCCCUGU | m7b | (m7b->m6b) | -0.228 | -0.12 |
0.01 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232040263A>G | ICGC_6DBE9968-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-216a |
aaagtgcTGAGATTAcagg |
2 |
UAAUCUCA | m8a | Disrupted | -0.011 | -0.097 |
1.73 |
hsa-miR-216b |
aaagtgctGAGATTacagg |
0 | AAAUCUCU | m6b | Disrupted | 0.075 | no TS |
0.03 |
hsa-miR-4530 |
aaagTGCTGGGattacagg |
0 | CCCAGCAG | m7a | Created | 0.066 | 0.066 |
-0.13 |
hsa-miR-4733-5p |
aaagtgcTGGGATTacagg |
0 | AAUCCCAA | m7a | Created | NA | NA |
-2.02 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.232040629C>T | COSN9061533 | C0065T | [kidney][NS][other][neoplasm] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-186-5p |
cctaaagtTTCTTTaatgt |
0 | CAAAGAAU | m6b | Created | no TS | 0.057000 |
-0.010000 |
hsa-miR-3133 |
cctaaagtTTCTTTAatgt |
2 |
UAAAGAAC | m7a | Created | 0.166000 | 0.224000 |
-0.010000 |