SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_001012957
Gene Symbol: DISC1
Description: Homo sapiens disrupted in schizophrenia 1 (DISC1), transcript variant Lv, mRNA.
Gene Location: chr1(+):231762560-232177019
Browse Associations

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr1:g.232037208G>A COSN6026767 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4684-3p tgcTGCAACAaaaatattt
0 UGUUGCAA m7a (m6a->m7a) no TS -0.129000 -0.100000
hsa-miR-744-3p tgctGCAACAaaaatattt
0 CUGUUGCC m6b Created no TS -0.106000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038383A>G COSN8447943 AOCS-055-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3667-3p cactgAGGAAGGTggcccc
0 ACCUUCCU m8a Disrupted -0.057000 -0.148000 0.050000
hsa-miR-4667-3p cactgAGGAGGGtggcccc
1
UCCCUCCU m7b Created -0.197000 -0.148000 -0.090000
hsa-miR-5193 cactGAGGAGGgtggcccc
0 UCCUCCUC m7b Created no TS 0.014000 -1.320000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038465T>C COSN15447231 AOCS-150-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4678 accatAATACCTgcttgga
0 AAGGUAUU m7b Created no TS 0.063000 -0.050000
hsa-miR-656 accATAATATctgcttgga
2
AAUAUUAU m7b (m7b->m6b) 0.242000 no TS 0.010000
hsa-miR-4678 accatAATACCTgcttgga
0 AAGGUAUU m7b Created no TS 0.063000 -0.050000
hsa-miR-656 accATAATATctgcttgga
2
AAUAUUAU m7b (m7b->m6b) 0.242000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038484T>C COSN1435640 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-210 gaaccacaACGCACAttag
0 CUGUGCGU m7b Created no TS -0.113000 -2.020000
hsa-miR-33a-5p gaaccaCAATGCACattag
0 GUGCAUUG m8a Disrupted 0.122000 0.099000 No effect
hsa-miR-33b-5p gaaccaCAATGCACattag
0 GUGCAUUG m8a Disrupted 0.122000 0.099000 No effect
hsa-miR-4289 gaacCACAATGCacattag
0 GCAUUGUG m8a Disrupted 0.064000 no TS 0.080000
hsa-miR-210 gaaccacaACGCACAttag
0 CUGUGCGU m7b Created no TS -0.113 -2.02
hsa-miR-33a-5p gaaccaCAATGCACattag
0 GUGCAUUG m8a Disrupted 0.122 0.099 -9.49
hsa-miR-33b-5p gaaccaCAATGCACattag
0 GUGCAUUG m8a Disrupted 0.122 0.099 9.5
hsa-miR-4289 gaacCACAATGCacattag
0 GCAUUGUG m8a Disrupted 0.064 no TS 0.08

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232038595T>C COSN8447945 AOCS-166-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4653-3p tcatgTAACTCCtattcat
2
UGGAGUUA m7b Disrupted -0.018000 no TS 4.390000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232039572C>T cosmic_v64_1732875 Medulloblastoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374b-3p cagaaagtCTGCTAAGggc
0 CUUAGCAG m8a Created no TS 0.085 -0.03
hsa-miR-4524a-5p cagaaagtCTGCTAagggc
0 AUAGCAGC m6b Created no TS 0.047 No effect
hsa-miR-4524b-5p cagaaagtCTGCTAagggc
0 AUAGCAGC m6b Created no TS 0.047 No effect
hsa-miR-4771 cagaaAGTCTGCTaagggc
0 AGCAGACU m8a Created -0.376 -0.43 -3.07
hsa-miR-499b-5p cagaAAGTCTGctaagggc
0 ACAGACUU m7b Created 0.008 0.008 -5.77

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232039676T>A COSN15357021 AOCS-034-3-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4307 tatcctcAAACATactata
0 AAUGUUUU m6b Created no TS 0.166000 0.040000
hsa-miR-4461 tatcCTCAATCatactata
1
GAUUGAGA m7a Disrupted 0.067000 0.067000 0.020000
hsa-miR-567 tatcctcaAACATACTata
0 AGUAUGUU m8a Created no TS 0.027000 0.210000
hsa-miR-4307 tatcctcAAACATactata
0 AAUGUUUU m6b Created no TS 0.166000 0.040000
hsa-miR-4461 tatcCTCAATCatactata
1
GAUUGAGA m7a Disrupted 0.067000 0.067000 0.020000
hsa-miR-567 tatcctcaAACATACTata
0 AGUAUGUU m8a Created no TS 0.027000 0.210000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040101A>C ICGC_6DBE8FCC-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-5p agctattctACTGCCTcag
0 CAGGCAGU m7b (m7b->m6c) -0.137 -0.101 No effect
hsa-miR-34b-5p agctattctACTGCCTcag
0 UAGGCAGU m7b (m7b->m6c) -0.212 -0.129 0.06
hsa-miR-449c-5p agctattctACTGCCTcag
0 UAGGCAGU m7b (m7b->m6c) -0.175 -0.111 No effect
hsa-miR-4722-5p agctattCTCCTGCCtcag
0 GGCAGGAG m8a Created 0.031 -0.029 -2.48
hsa-miR-4768-3p agctatTCTCCTGcctcag
0 CCAGGAGA m7b Created -0.163 -0.16 -0.04
hsa-miR-936 agctatTCTACTGcctcag
1
ACAGUAGA m7b Disrupted -0.021 no TS 1.5
hsa-miR-940 agctattctCCTGCCTcag
0 AAGGCAGG m7b (m6c->m7b) -0.037 -0.091 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040185C>T ICGC_6DBE949A-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10a-5p gagACAGGGTttcaccatg
0 UACCCUGU m7b (m6b->m7b) no TS -0.078 -0.93
hsa-miR-10b-5p gagACAGGGTttcaccatg
0 UACCCUGU m7b (m6b->m7b) no TS -0.078 -0.24
hsa-miR-146b-3p gagACAGGGCttcaccatg
0 UGCCCUGU m7b (m7b->m6b) -0.228 -0.12 0.01

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040263A>G ICGC_6DBE9968-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-216a aaagtgcTGAGATTAcagg
2
UAAUCUCA m8a Disrupted -0.011 -0.097 1.73
hsa-miR-216b aaagtgctGAGATTacagg
0 AAAUCUCU m6b Disrupted 0.075 no TS 0.03
hsa-miR-4530 aaagTGCTGGGattacagg
0 CCCAGCAG m7a Created 0.066 0.066 -0.13
hsa-miR-4733-5p aaagtgcTGGGATTacagg
0 AAUCCCAA m7a Created NA NA -2.02

Mutation Mutation ID Sample Name Cancer Type
chr1:g.232040629C>T COSN9061533 C0065T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p cctaaagtTTCTTTaatgt
0 CAAAGAAU m6b Created no TS 0.057000 -0.010000
hsa-miR-3133 cctaaagtTTCTTTAatgt
2
UAAAGAAC m7a Created 0.166000 0.224000 -0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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