SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_004717
Gene Symbol: DGKI
Description: Homo sapiens diacylglycerol kinase, iota (DGKI), mRNA.
Gene Location: chr7(-):137074384-137531609
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390032T>C COSN5649142 RK118_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548aa gttttTGGTTTTcattact
 0 AAAAACCA m7b Disrupted -0.171000 -0.071000 0.070000
hsa-miR-548ap-3p gttttTGGTTTTcattact
 0 AAAAACCA m7b Disrupted -0.171000 -0.071000 No effect
hsa-miR-548t-3p gttttTGGTTTTcattact
 0 AAAAACCA m7b Disrupted -0.171000 -0.071000 0.070000
hsa-miR-570-3p gtttttgGTTTTCattact
 10
 CGAAAACA m6b Disrupted -0.022000 no TS 0.530000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390157T>A COSN7962899 8058330 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-489 agcaacatATGTCAacata
 11
 GUGACAUC m6b Disrupted -0.100000 -0.030000 1.300000
hsa-miR-5580-3p agcaaCATATGTcaacata
 2
 CACAUAUG m7b Disrupted -0.164000 -0.088000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390335G>C COSN2204263 RK126_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273g-5p tagtttgcaCAACCACtca
 0 GGUGGUUG m7b (m6b->m7b) no TS -0.164000 No effect
hsa-miR-19a-3p tagTTTGCACAaccactca
 6
 UGUGCAAA m8a Created -0.088000 -0.201000 -0.140000
hsa-miR-19b-3p tagTTTGCACAaccactca
 6
 UGUGCAAA m8a Created -0.088000 -0.201000 No effect
hsa-miR-2276 tagtTTGCAGAaccactca
 6
 UCUGCAAG m7a Disrupted -0.100000 -0.065000 0.110000
hsa-miR-323b-5p tagtttgcACAACCactca
 0 AGGUUGUC m6b Created no TS -0.080000 -0.580000
hsa-miR-4772-3p tagtTTGCAGaaccactca
 6
 CCUGCAAC m6b Disrupted -0.091000 -0.054000 3.720000
hsa-miR-518a-5p tagTTTGCAGaaccactca
 0 CUGCAAAG m7a (m7a->m6b) NA NA No effect
hsa-miR-527 tagTTTGCAGaaccactca
 0 CUGCAAAG m7a (m7a->m6b) NA NA No effect
hsa-miR-544a tagttTGCAGAAccactca
 11
 AUUCUGCA m7b Disrupted -0.306000 -0.189000 1.090000
hsa-miR-548aw tagTTTGCACaaccactca
 0 GUGCAAAA m7a (m6b->m7a) NA NA 0.720000
hsa-miR-1273g-5p tagtttgcaCAACCACtca
 0 GGUGGUUG m7b (m6b->m7b) no TS -0.164 No effect
hsa-miR-19a-3p tagTTTGCACAaccactca
 0 UGUGCAAA m8a Created -0.088 -0.201 -0.14
hsa-miR-19b-3p tagTTTGCACAaccactca
 0 UGUGCAAA m8a Created -0.088 -0.201 No effect
hsa-miR-2276 tagtTTGCAGAaccactca
 0 UCUGCAAG m7a Disrupted -0.1 -0.065 0.11
hsa-miR-323b-5p tagtttgcACAACCactca
 0 AGGUUGUC m6b Created no TS -0.08 -0.58
hsa-miR-4772-3p tagtTTGCAGaaccactca
 0 CCUGCAAC m6b Disrupted -0.091 -0.054 3.72
hsa-miR-518a-5p tagTTTGCAGaaccactca
 0 CUGCAAAG m7a (m7a->m6b) NA NA No effect
hsa-miR-527 tagTTTGCAGaaccactca
 0 CUGCAAAG m7a (m7a->m6b) NA NA No effect
hsa-miR-544a tagttTGCAGAAccactca
 0 AUUCUGCA m7b Disrupted -0.306 -0.189 1.09
hsa-miR-548aw tagTTTGCACaaccactca
 0 GUGCAAAA m7a (m6b->m7a) NA NA 0.72

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390409G>T COSN6515567 HX30T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1283 actgcctaTTTGTAGccat
 0 UCUACAAA m7b Created no TS 0.012000 -0.260000
hsa-miR-187-5p actgcctatTTGTAGCCat
 0 GGCUACAA m8a (m7a->m8a) no TS -0.106000 -0.620000
hsa-miR-4643 actgcctATGTGTagccat
 8
 GACACAUG m6b Disrupted 0.052000 no TS 2.300000
hsa-miR-466 actgcctATGTGTAgccat
 8
 AUACACAU m7b Disrupted 0.015000 no TS 5.120000
hsa-miR-4789-3p actgccTATGTGTagccat
 7
 CACACAUA m7b Disrupted 0.034000 no TS 4.630000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390480G>C 0_275 Lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4530 gcccaggCTGCTGGGctgt
 9
 CCCAGCAG m8a Disrupted -0.024 no TS No effect
hsa-miR-665 gcccaggCTCCTGGgctgt
 11
 ACCAGGAG m7b Created no TS -0.026 -0.29

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390494G>T COSN14594453 8052598 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-331-3p taacCCAGGGGtcagccca
 0 GCCCCUGG m7b Disrupted -0.137000 no TS 5.270000
hsa-miR-4292 taaCCCAGGGGtcagccca
 0 CCCCUGGG m8a Disrupted -0.167000 no TS -0.780000
hsa-miR-331-3p taacCCAGGGGtcagccca
 0 GCCCCUGG m7b Disrupted -0.137000 no TS 5.270000
hsa-miR-4292 taaCCCAGGGGtcagccca
 0 CCCCUGGG m8a Disrupted -0.167000 no TS -0.780000
hsa-miR-331-3p taacCCAGGGGtcagccca
 0 GCCCCUGG m7b Disrupted -0.137000 no TS 5.270000
hsa-miR-4292 taaCCCAGGGGtcagccca
 0 CCCCUGGG m8a Disrupted -0.167000 no TS -0.780000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390633C>T COSN7962901 8058336 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-5p cccctcaCCTGCCAaccct
 6
 UGGCAGGG m7a Created -0.168000 -0.260000 -5.410000
hsa-miR-125a-3p ccccTCACCTGccaaccct
 15
 ACAGGUGA m7b Created -0.231000 -0.257000 -2.470000
hsa-miR-1908 cccctcaCCCGCCaaccct
 0 CGGCGGGG m6b Disrupted -0.169000 no TS 4.390000
hsa-miR-3656 cccctCACCCGCCaaccct
 0 GGCGGGUG m8a Disrupted -0.254000 no TS 2.830000
hsa-miR-3665 cccctCACCTGCcaaccct
 0 AGCAGGUG m7b Created no TS -0.137000 -14.780000
hsa-miR-4710 ccCCTCACCCgccaaccct
 1
 GGGUGAGG m8a (m8a->m7b) -0.059000 -0.086000 0.310000
hsa-miR-4730 cccctcacCCGCCAaccct
 0 CUGGCGGA m6b Disrupted -0.199000 no TS 9.000000
hsa-miR-4736 cccctcACCTGCCaaccct
 2
 AGGCAGGU m7b Created -0.450000 -0.708000 -1.820000
hsa-miR-4763-3p cccctcaCCTGCCaaccct
 6
 AGGCAGGG m6b Created -0.168000 -0.247000 -4.670000
hsa-miR-657 cccctcACCTGCCaaccct
 2
 GGCAGGUU m7a Created -0.191000 -0.191000 -0.890000
hsa-miR-663a cccctcaCCCGCCaaccct
 0 AGGCGGGG m6b Disrupted -0.179000 no TS 11.000000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390890A>C COSN15009175 LP6005409-DNA_A02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4659a-5p gttcgtataCATGGCActg
 0 CUGCCAUG m7b (m6b->m7b) no TS -0.215000 -3.640000
hsa-miR-4659b-5p gttcgtataCATGGCActg
 0 UUGCCAUG m7b (m6b->m7b) no TS -0.215000 -3.640000
hsa-miR-4729 gttcgtATAAATGgcactg
 8
 UCAUUUAU m7b Disrupted 0.051000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137390981A>C COSN7962902 8061178 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2113 gagttcCACAAAatttgat
 0 AUUUGUGC m6b Disrupted -0.065000 no TS No effect
hsa-miR-3165 gagtTCCACCaaatttgat
 0 AGGUGGAU m6b Created no TS -0.178000 No effect
hsa-miR-3190-3p gagTTCCACAaaatttgat
 10
 UGUGGAAG m7a (m7a->m6b) -0.126000 no TS No effect
hsa-miR-4752 gagtTCCACAAaatttgat
 13
 UUGUGGAU m7a Disrupted -0.140000 no TS 0.040000
hsa-miR-5002-5p gagttccACCAAATTtgat
 2
 AAUUUGGU m8a Created -0.068000 -0.132000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.137391101A>T COSN8314910 TCGA-AC-A3W6-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376a-5p cctgcaaGAATCTACctga
 3
 GUAGAUUC m8a Disrupted -0.156000 -0.059000 3.400000
hsa-miR-4650-3p cctgcaagaTTCTACCTga
 0 AGGUAGAA m8a (m7a->m8a) no TS -0.179000 -2.180000


Mutation Mutation ID Sample Name Cancer Type
chr7:g.137391159G>T COSN8515525 202_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.137391199G>A COSN8515526 4095_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3909 gggcaaAGAGGACAtgagc
 1
 UGUCCUCU m8a Disrupted -0.419000 no TS 1.810000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
137389799 rs200308792 - - hsa-miR-376a-5p
3
 ttgGAATCTAgcc
 Unknown
N
 -0.059
A
137390474 rs202223501 T C hsa-miR-4690-3p
hsa-miR-548v
hsa-miR-5685
hsa-miR-6856-3p
8
3
8
2
 gcTGGGCTGtagc
gctgggCTGTAGC
gcTGGGCTGtagc
gctGGGCTGTAgc
 Created
Created
Created
Created
N
N
N
N
 -0.078
-0.006
-0.068
-0.236
T hsa-miR-187-5p
3
 gctgggTTGTAGC
 Disrupted
N
 0.008
137391101 rs1731951 T A hsa-miR-376a-2-5p
hsa-miR-376a-5p
2
7
 gcaagAATCTACc
gcaaGAATCTAcc
 Created
Created
N
N
 -0.096
-0.097
T hsa-miR-4650-3p
9
 gcaagaTTCTACC
 Disrupted
N
 -0.179

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