SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001202523
Gene Symbol:	DDR1
Description:	Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 4, mRNA.
Gene Location:	chr6(+):30852756-30867933
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.30899321T>G			COSN2159336		RK091_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-125a-5p	gcccctccCTCAGGGAgcg	0	UCCCUGAG	m8a	Disrupted	-0.299000	no TS	2.720000
hsa-miR-125b-5p	gcccctccCTCAGGGAgcg	0	UCCCUGAG	m8a	Disrupted	-0.288000	no TS	4.370000
hsa-miR-1321	gccCCTCCCTcagggagcg	2	CAGGGAGG	m7b	(m7b->m6b)	-0.133000	no TS	1.070000
hsa-miR-149-3p	gcCCCTCCCTcagggagcg	2	AGGGAGGG	m8a	(m8a->m7a)	-0.373000	-0.343000	-0.090000
hsa-miR-345-3p	gcccctcccTCAGGGagcg	0	GCCCUGAA	m6b	Disrupted	-0.122000	no TS	23.220000
hsa-miR-4319	gcccctccCTCAGGGAgcg	0	UCCCUGAG	m8a	Disrupted	-0.309000	no TS	5.020000
hsa-miR-4324	gcccctccCTCAGGGagcg	0	CCCUGAGA	m7a	Disrupted	NA	NA	1.850000
hsa-miR-4419a	gcccCTCCCTCAgggagcg	2	UGAGGGAG	m8a	Disrupted	-0.305000	no TS	2.220000
hsa-miR-4510	gcccCTCCCTCAgggagcg	2	UGAGGGAG	m8a	Disrupted	-0.305000	no TS	10.870000
hsa-miR-4732-3p	gcccctcccTCAGGGagcg	0	GCCCUGAC	m6b	Disrupted	-0.106000	no TS	1.980000
hsa-miR-4734	gcccctCCCGCAGggagcg	0	GCUGCGGG	m7b	Created	no TS	-0.251000	-0.090000
hsa-miR-4739	gccCCTCCCTcagggagcg	2	AAGGGAGG	m7b	(m7b->m6b)	-0.133000	no TS	No effect
hsa-miR-4756-5p	gccCCTCCCTcagggagcg	2	CAGGGAGG	m7b	(m7b->m6b)	-0.123000	no TS	0.010000
hsa-miR-544b	gcccctcCCTCAGGgagcg	0	ACCUGAGG	m7b	Disrupted	-0.147000	no TS	8.680000
hsa-miR-670	gcccctcccTCAGGGAgcg	0	GUCCCUGA	m7b	(m7b->m6c)	-0.072000	no TS	4.390000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.30899394C>T			COSN1331063		BN24T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-149-3p	ttcCCCTCCCgacagccca	2	AGGGAGGG	m7b	(m7b->m6b)	-0.373000	-0.167000	-0.270000
hsa-miR-4433-3p	ttcccCTCCTGacagccca	0	ACAGGAGU	m6b	Created	no TS	-0.085000	0.030000
hsa-miR-4459	ttccCCTCCTGacagccca	0	CCAGGAGG	m7b	Created	no TS	-0.309000	-1.350000
hsa-miR-4695-5p	ttccCCTCCTGacagccca	0	CAGGAGGC	m7a	Created	NA	NA	-1.990000
hsa-miR-4728-5p	ttcCCCTCCCgacagccca	2	UGGGAGGG	m7b	(m7b->m6b)	-0.382000	-0.167000	-0.570000
hsa-miR-4768-3p	ttcccCTCCTGacagccca	0	CCAGGAGA	m6b	Created	no TS	-0.079000	-1.110000
hsa-miR-4779	ttcCCCTCCTgacagccca	2	UAGGAGGG	m7b	(m6b->m7b)	-0.152000	-0.304000	-0.130000
hsa-miR-149-3p	ttcCCCTCCCgacagccca	2	AGGGAGGG	m7b	(m7b->m6b)	-0.373000	-0.167000	-0.270000
hsa-miR-4433-3p	ttcccCTCCTGacagccca	0	ACAGGAGU	m6b	Created	no TS	-0.085000	0.030000
hsa-miR-4459	ttccCCTCCTGacagccca	0	CCAGGAGG	m7b	Created	no TS	-0.309000	-1.350000
hsa-miR-4695-5p	ttccCCTCCTGacagccca	0	CAGGAGGC	m7a	Created	NA	NA	-1.990000
hsa-miR-4728-5p	ttcCCCTCCCgacagccca	2	UGGGAGGG	m7b	(m7b->m6b)	-0.382000	-0.167000	-0.570000
hsa-miR-4768-3p	ttcccCTCCTGacagccca	0	CCAGGAGA	m6b	Created	no TS	-0.079000	-1.110000
hsa-miR-4779	ttcCCCTCCTgacagccca	2	UAGGAGGG	m7b	(m6b->m7b)	-0.152000	-0.304000	-0.130000
hsa-miR-149-3p	ttcCCCTCCCgacagccca	2	AGGGAGGG	m7b	(m7b->m6b)	-0.373	-0.167	-0.27
hsa-miR-4433-3p	ttcccCTCCTGacagccca	0	ACAGGAGU	m6b	Created	no TS	-0.085	0.03
hsa-miR-4459	ttccCCTCCTGacagccca	0	CCAGGAGG	m7b	Created	no TS	-0.309	-1.35
hsa-miR-4695-5p	ttccCCTCCTGacagccca	0	CAGGAGGC	m7a	Created	NA	NA	-1.99
hsa-miR-4728-5p	ttcCCCTCCCgacagccca	2	UGGGAGGG	m7b	(m7b->m6b)	-0.382	-0.167	-0.57
hsa-miR-4768-3p	ttcccCTCCTGacagccca	0	CCAGGAGA	m6b	Created	no TS	-0.079	-1.11
hsa-miR-4779	ttcCCCTCCTgacagccca	0	UAGGAGGG	m7b	(m6b->m7b)	-0.152	-0.304	-0.13

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
30899323	rs201879795	A	A	hsa-miR-125a-5p hsa-miR-125b-5p hsa-miR-3126-5p hsa-miR-345-3p hsa-miR-4319 hsa-miR-4419a hsa-miR-4510 hsa-miR-4732-3p hsa-miR-544b hsa-miR-6127 hsa-miR-6129 hsa-miR-6130 hsa-miR-6133 hsa-miR-670-5p hsa-miR-6834-5p hsa-miR-6875-5p hsa-miR-7106-3p hsa-miR-7113-3p	6 6 2 6 6 2 2 6 6 2 2 2 2 6 2 2 22 9	tccCTCAGGGAgc tccCTCAGGGAgc TCCCTCAgggagc tcccTCAGGGAgc tccCTCAGGGAgc TCCCTCAgggagc TCCCTCAgggagc tcccTCAGGGAgc tcCCTCAGGgagc TCCCTCAgggagc TCCCTCAgggagc TCCCTCAgggagc TCCCTCAgggagc tcccTCAGGGAgc TCCCTCAgggagc TCCCTCAgggagc tccctcAGGGAGC tccctCAGGGAGc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N N N	-0.299 -0.288 -0.11 -0.122 -0.309 -0.202 -0.202 -0.106 -0.147 -0.201 -0.2 -0.2 -0.202 -0.072 -0.091 -0.11 -0.172 -0.144
30899571	rs2524232	T	T	hsa-miR-3125 hsa-miR-3916 hsa-miR-4779 hsa-miR-6804-5p hsa-miR-6859-5p hsa-miR-877-5p	1 1 2 1 1 1	ccacccTCCTCTA ccacccTCCTCTA ccaCCCTCCTcta cCACCCTCctcta ccacccTCCTCTA ccacccTCCTCTA	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.067 -0.047 -0.152 -0.157 -0.04 -0.046
			A	hsa-miR-1293 hsa-miR-363-5p hsa-miR-4483 hsa-miR-6134 hsa-miR-6745 hsa-miR-6748-5p hsa-miR-6756-5p hsa-miR-6766-5p hsa-miR-6769a-5p hsa-miR-6769b-5p	1 1 1 2 1 1 1 1 1 1	CCACCCAcctcta CCACCCAcctcta CCACCCAcctcta ccacCCACCTCta CCACCCAcctcta cCACCCACctcta CCACCCAcctcta CCACCCAcctcta ccACCCACCtcta ccACCCACCtcta	Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N	-0.134 -0.163 -0.113 -0.133 -0.162 -0.164 -0.111 -0.118 -0.182 -0.182

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