SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001202521
Gene Symbol:	DDR1
Description:	Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 4, mRNA.
Gene Location:	chr6(+):30856464-30867933
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.30897395C>C			ICGC_55486		TCGA-DK-A3IT-01A-31D-A20D-08		BladderUrothelialCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1306-5p	ttcctgaaaGAGGTGaaga	0	CCACCUCC	m6b	Disrupted	-0.181	-0.02	No effect
hsa-miR-130b-5p	ttcctGAAAGAGgtgaaga	0	ACUCUUUC	m7b	Disrupted	1.162	1.261	No effect
hsa-miR-30a-3p	ttcCTGAAAGaggtgaaga	0	CUUUCAGU	m7a	(m7a->m6a)	NA	NA	No effect
hsa-miR-30d-3p	ttcCTGAAAGaggtgaaga	0	CUUUCAGU	m7a	(m7a->m6a)	NA	NA	No effect
hsa-miR-30e-3p	ttcCTGAAAGaggtgaaga	0	CUUUCAGU	m7a	(m7a->m6a)	NA	NA	No effect
hsa-miR-3622a-3p	ttcctgaaaCAGGTGAaga	0	UCACCUGA	m7a	(m6b->m7a)	no TS	-0.153	-0.38
hsa-miR-3622b-3p	ttcctgaaaCAGGTGAaga	0	UCACCUGA	m7a	(m6b->m7a)	no TS	-0.146	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.30897579C>T			ICGC_1341002		TCGA-D1-A0ZO-01A-11D-A122-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1539	ggcaggctGCGCAGGggcc	0	UCCUGCGC	m7b	Disrupted	-0.263	-0.079	0.09

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.30897582A>T			ICGC_ssm_v3_53455		HCC119T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1539	aggctGCGCAGGggcccac	0	UCCUGCGC	m7b	Disrupted	-0.263	-0.079	0.12
hsa-miR-4738-5p	aggctGCGCTGGggcccac	0	ACCAGCGC	m7b	Created	-0.42	-0.597	-0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.30899394C>T			ICGC_ssm_v3_9482		BN24T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-149-3p	ttcCCCTCCCgacagccca	0	AGGGAGGG	m7b	(m7b->m6b)	-0.203	-0.119	0.32
hsa-miR-4433-3p	ttcccCTCCTGacagccca	0	ACAGGAGU	m6b	Created	no TS	0.009	5.79
hsa-miR-4459	ttccCCTCCTGacagccca	0	CCAGGAGG	m7b	Created	no TS	-0.092	-0.46
hsa-miR-4695-5p	ttccCCTCCTGacagccca	0	CAGGAGGC	m7a	Created	NA	NA	-11.99
hsa-miR-4728-5p	ttcCCCTCCCgacagccca	0	UGGGAGGG	m7b	(m7b->m6b)	-0.248	-0.155	0.16
hsa-miR-4768-3p	ttcccCTCCTGacagccca	0	CCAGGAGA	m6b	Created	no TS	0.015	8.35
hsa-miR-4779	ttcCCCTCCTgacagccca	0	UAGGAGGG	m7b	(m6b->m7b)	-0.073	-0.103	11.48

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
30897580	rs148278902	G	G	hsa-miR-1539 hsa-miR-6801-3p hsa-miR-6810-3p	7 7 7	ggctGCGCAGGgg ggctgcGCAGGGG ggctgcGCAGGGG	Disrupted Disrupted Disrupted	N N N	-0.184 -0.115 -0.105
			A	hsa-miR-143-5p hsa-miR-1914-5p hsa-miR-3944-5p hsa-miR-7156-3p	11 7 11 10	ggCTGCACAgggg ggctGCACAGGgg gGCTGCACAgggg GGCTGCAcagggg	Created Created Created Created	N N N N	-0.042 -0.119 -0.237 -0.099

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