SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_133503
Gene Symbol:	DCN
Description:	Homo sapiens decorin (DCN), transcript variant A1, mRNA.
Gene Location:	chr12(-):91539034-91573359
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91145300C>G			COSN5331426		RK298_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-10a-3p	ctgatgtttGAATTTaccc	0	CAAAUUCG	m6b	Created	no TS	-0.022000	-6.480000
hsa-miR-4760-3p	ctgatgttTGAATTTaccc	0	AAAUUCAU	m7a	Created	NA	NA	-2.730000
hsa-miR-494	ctgATGTTTCAatttaccc	2	UGAAACAU	m8a	Disrupted	-0.196000	no TS	4.470000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91145332C>T			COSN5331427		RK125_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1277-5p	caaagcATATATTTcctga	0	AAAUAUAU	m8a	Created	no TS	0.045000	-0.060000
hsa-miR-5093	caaagcataCATTTCCTga	0	AGGAAAUG	m8a	(m8a->m7a)	-0.291000	-0.125000	1.590000
hsa-miR-675-3p	caaaGCATACAtttcctga	0	CUGUAUGC	m7b	Disrupted	-0.260000	no TS	0.500000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.91145627G>A			COSN9084881		8051715		[pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3923	atcatTACTAGTaaagcct	0	AACUAGUA	m7b	Created	no TS	-0.358000	-2.370000
hsa-miR-628-3p	atcaTTACTAGtaaagcct	1	UCUAGUAA	m7b	Created	-0.110000	-0.275000	-2.320000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
91145738	rs3138290	C	C	hsa-miR-1343-3p hsa-miR-3690 hsa-miR-4254 hsa-miR-5093 hsa-miR-6783-3p hsa-miR-875-3p	6 6 6 4 6 4	taatttCCAGGAA taattTCCAGGAa taattTCCAGGAa taATTTCCAggaa taatttCCAGGAA taaTTTCCAGgaa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.17 -0.205 -0.187 -0.057 -0.177 -0.206
			T	hsa-miR-1200 hsa-miR-3140-5p hsa-miR-378a-5p	6 6 6	taatttTCAGGAA taattTTCAGGAa taatttTCAGGAA	Created Created Created	N N N	-0.164 -0.173 -0.153

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