| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_022836 |
|---|---|
| Gene Symbol: | DCLRE1B |
| Description: | Homo sapiens DNA cross-link repair 1B (DCLRE1B), mRNA. |
| Gene Location: | chr1(+):114447914-114456708 |
| Browse Associations | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.113912322C>T | COSN8318173 | PCSI_0083_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-128 |
tgggccCACTGTGgagcag |
0 | UCACAGUG | m7b | Created | no TS | -0.075000 |
0.420000 |
|
| hsa-miR-194-3p |
tgggCCCACTGtggagcag |
0 | CCAGUGGG | m7b | Created | no TS | -0.159000 |
-0.590000 |
|
| hsa-miR-3681-3p |
tgggccCACTGTGgagcag |
0 | ACACAGUG | m7b | Created | no TS | -0.094000 |
-0.020000 |
|
| hsa-miR-541-3p |
tggGCCCACCgtggagcag |
2 |
UGGUGGGC | m7b | (m7b->m6b) | -0.223000 | no TS |
0.200000 |
|
| hsa-miR-654-5p |
tggGCCCACCgtggagcag |
2 |
UGGUGGGC | m7b | (m7b->m6b) | -0.233000 | no TS |
2.550000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.113913146C>T | COSN14646126 | PCSI_0044_Pa_P | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1224-3p |
gccagctGGTGGGaagggg |
0 | CCCCACCU | m6b | Created | -0.187000 | -0.240000 |
-2.620000 |
|
| hsa-miR-1226-3p |
gccaGCTGGTGggaagggg |
2 |
UCACCAGC | m7b | Created | -0.240000 | -0.288000 |
-0.120000 |
|
| hsa-miR-1260a |
gccagctGGTGGGAagggg |
0 | AUCCCACC | m7b | Created | -0.496000 | -0.629000 |
-0.200000 |
|
| hsa-miR-1260b |
gccagctGGTGGGAagggg |
0 | AUCCCACC | m7b | Created | -0.496000 | -0.629000 |
-0.220000 |
|
| hsa-miR-1280 |
gccagctGGTGGGAagggg |
0 | UCCCACCG | m7a | Created | -0.213000 | -0.271000 |
-1.610000 |
|
| hsa-miR-188-3p |
gccagctgGTGGGAagggg |
0 | CUCCCACA | m6b | Created | -0.177000 | -0.195000 |
-0.060000 |
|
| hsa-miR-3156-3p |
gccagctgGTGGGAagggg |
0 | CUCCCACU | m6b | Created | -0.184000 | -0.205000 |
-0.270000 |
|
| hsa-miR-4258 |
gccagcTGGCGGGaagggg |
1 |
CCCCGCCA | m7b | Disrupted | -0.297000 | no TS |
0.850000 |
|
| hsa-miR-1224-3p |
gccagctGGTGGGaagggg |
0 | CCCCACCU | m6b | Created | -0.187000 | -0.240000 |
-2.620000 |
|
| hsa-miR-1226-3p |
gccaGCTGGTGggaagggg |
2 |
UCACCAGC | m7b | Created | -0.240000 | -0.288000 |
-0.120000 |
|
| hsa-miR-1260a |
gccagctGGTGGGAagggg |
0 | AUCCCACC | m7b | Created | -0.496000 | -0.629000 |
-0.200000 |
|
| hsa-miR-1260b |
gccagctGGTGGGAagggg |
0 | AUCCCACC | m7b | Created | -0.496000 | -0.629000 |
-0.220000 |
|
| hsa-miR-1280 |
gccagctGGTGGGAagggg |
0 | UCCCACCG | m7a | Created | -0.213000 | -0.271000 |
-1.610000 |
|
| hsa-miR-188-3p |
gccagctgGTGGGAagggg |
0 | CUCCCACA | m6b | Created | -0.177000 | -0.195000 |
-0.060000 |
|
| hsa-miR-3156-3p |
gccagctgGTGGGAagggg |
0 | CUCCCACU | m6b | Created | -0.184000 | -0.205000 |
-0.270000 |
|
| hsa-miR-4258 |
gccagcTGGCGGGaagggg |
1 |
CCCCGCCA | m7b | Disrupted | -0.297000 | no TS |
0.850000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.113913285G>A | COSN8308765 | TCGA-EW-A2FR-01 | [breast][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-488-5p |
gagctgggcATCTGGatca |
0 | CCCAGAUA | m6b | Created | no TS | -0.029000 |
-7.070000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.113913398T>C | COSN8635411 | 949_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4263 |
aatagagagCTTAGAAagc |
7 |
AUUCUAAG | m7b | (m6c->m7b) | 0.070000 | 0.011000 |
0.160000 |
|
| hsa-miR-4799-5p |
aatagagagTTTAGAaagc |
8 |
AUCUAAAU | m6b | Disrupted | 0.044000 | no TS |
0.760000 |
|
| hsa-miR-618 |
aatagAGAGTTTagaaagc |
0 | AAACUCUA | m7a | Disrupted | NA | NA |
0.010000 |
|
| hsa-miR-99a-3p |
aatagaGAGCTTagaaagc |
0 | CAAGCUCG | m6b | Created | no TS | -0.120000 |
-0.940000 |
|
| hsa-miR-99b-3p |
aatagaGAGCTTagaaagc |
0 | CAAGCUCG | m6b | Created | no TS | -0.107000 |
-0.980000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr1:g.113913547G>A | COSN8308766 | TCGA-EW-A2FR-01 | [breast][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-10b-3p |
ctcGAATCTGTggcaccct |
1 |
ACAGAUUC | m8a | Disrupted | -0.050000 | no TS |
2.370000 |
|
| hsa-miR-1227 |
ctcgaatctGTGGCACcct |
1 |
CGUGCCAC | m7b | (m7b->m6c) | -0.185000 | no TS |
3.650000 |
|
| hsa-miR-3064-3p |
ctcgaatcTGTGGCAccct |
1 |
UUGCCACA | m7b | Disrupted | -0.087000 | no TS |
4.070000 |
|
| hsa-miR-376a-5p |
ctcGAATCTAtggcaccct |
0 | GUAGAUUC | m7b | (m6b->m7b) | no TS | -0.008000 |
-0.280000 |
|
| hsa-miR-5590-5p |
ctcgaatcTATGGCAccct |
0 | UUGCCAUA | m7b | Created | no TS | -0.063000 |
-0.030000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr1:g.113913618C>T | COSN9360990 | C0018T | [kidney][NS][other][neoplasm] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-let-7a-5p |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.369000 | -0.208000 |
0.160000 |
| hsa-let-7b-5p |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.369000 | -0.208000 | No effect |
| hsa-let-7c |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.369000 | -0.208000 | No effect |
| hsa-let-7d-5p |
agattcCTACCTCTcatga |
5 |
AGAGGUAG | m8a | Disrupted | -0.369000 | -0.208000 |
0.080000 |
| hsa-let-7e-5p |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.369000 | -0.208000 |
0.570000 |
| hsa-let-7f-5p |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.379000 | -0.218000 |
-0.030000 |
| hsa-let-7g-5p |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.379000 | -0.218000 |
0.180000 |
| hsa-let-7i-5p |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.379000 | -0.218000 |
-0.020000 |
| hsa-miR-4458 |
agattcCTACCTCTcatga |
5 |
AGAGGUAG | m8a | Disrupted | -0.351000 | -0.171000 |
0.360000 |
| hsa-miR-4500 |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.425000 | -0.236000 |
1.080000 |
| hsa-miR-98 |
agattcCTACCTCtcatga |
5 |
UGAGGUAG | m7b | Disrupted | -0.369000 | -0.208000 |
0.010000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 113913285 | rs6674384 | A | G |
hsa-miR-6786-3p |
0 |
ctGGGCGTCtgga |
Created |
N |
-0.236 |
| A |
hsa-miR-488-5p |
0 |
ctgggcATCTGGA |
Disrupted |
N |
-0.029 |
|||
| 113913547 | rs72996202 | G | G |
hsa-miR-10b-3p hsa-miR-1227-3p hsa-miR-3064-3p |
1 1 1 |
GAATCTGtggcac gaatctGTGGCAC gaatcTGTGGCAc |
Disrupted Disrupted Disrupted |
N N N |
-0.05 -0.185 -0.087 |
| A |
hsa-miR-376a-5p hsa-miR-5590-5p |
1 1 |
GAATCTAtggcac gaatcTATGGCAc |
Created Created |
N N |
-0.008 -0.063 |
|||
| 113913619 | rs185040335 | C | C |
hsa-let-7a-5p hsa-let-7b-5p hsa-let-7c-5p hsa-let-7d-5p hsa-let-7e-5p hsa-let-7f-5p hsa-let-7g-5p hsa-let-7i-5p hsa-miR-4458 hsa-miR-4500 hsa-miR-4712-3p hsa-miR-98-5p |
5 5 5 5 5 5 5 5 5 5 5 5 |
tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcCTACCTCtcat tcctacCTCTCAT tcCTACCTCtcat |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N N N |
-0.161 -0.161 -0.161 -0.161 -0.161 -0.161 -0.161 -0.161 -0.18 -0.189 -0.122 -0.161 |
| T |
hsa-miR-1253 hsa-miR-6770-5p |
6 6 |
tcctaCTTCTCAt tcctaCTTCTCAt |
Created Created |
N N |
-0.064 -0.062 |