SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005215
Gene Symbol: DCC
Description: Homo sapiens deleted in colorectal carcinoma (DCC), mRNA.
Gene Location: chr18(+):49866541-51062273
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr18:g.53530795A>C COSN8680077 SS6003109 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3977 agatccTGAAGCAgttcag
 11
 GUGCUUCA m7b Disrupted -0.145000 no TS 0.380000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53530878C>A COSN1207228 BN19T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3140-3p aaaCAAAAGCaaagatgca
 4
 AGCUUUUG m7b (m7b->m6b) -0.259000 no TS 0.400000
hsa-miR-3140-3p aaaCAAAAGCaaagatgca
 4
 AGCUUUUG m7b (m7b->m6b) -0.259 no TS 0.4

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53530975T>C COSN5846644 HX27T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-424-3p taatacctACGTTTTcctt
 0 CAAAACGU m7b Created no TS -0.098000 -1.110000
hsa-miR-570-3p taatacctaTGTTTTCctt
 1
 CGAAAACA m7b (m7b->m6c) -0.094000 0.003000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53531366C>A COSN9337788 AOCS-138-3-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3692-5p ggcattctgCCAGCAGcag
 10
 CCUGCUGG m7b (m7b->m6c) -0.295000 -0.180000 -0.010000
hsa-miR-626 ggcattctGACAGCagcag
 0 AGCUGUCU m6b Created no TS -0.102000 -4.960000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53531617G>C COSN4774233 tumor_4177987 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3190-5p aaaTGGCCAGctccacatg
 6
 UCUGGCCA m7b (m7b->m6b) -0.339000 -0.227000 -1.980000
hsa-miR-3689d aaatggcCACCTCCacatg
 0 GGGAGGUG m7b Created no TS -0.163000 0.020000
hsa-miR-4487 aaatggCCAGCTCcacatg
 5
 AGAGCUGG m7b Disrupted -0.034000 no TS No effect
hsa-miR-4633-3p aaatggccAGCTCCacatg
 18
 AGGAGCUA m6b Disrupted -0.187000 -0.127000 0.400000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53531757G>A COSN1747450 RK012_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-5p gccaactCTGCCTacaggg
 1
 CAGGCAGU m6b Disrupted -0.035000 no TS 0.020000
hsa-miR-3529-5p gccaacTCTACCTacaggg
 0 AGGUAGAC m7a Created NA NA No effect
hsa-miR-3927 gccaacTCTACCTacaggg
 0 CAGGUAGA m7b Created no TS -0.068000 No effect
hsa-miR-4451 gccaaCTCTACCtacaggg
 0 UGGUAGAG m7b Created no TS -0.098000 No effect
hsa-miR-4650-3p gccaacTCTACCTacaggg
 0 AGGUAGAA m7a Created NA NA No effect
hsa-miR-940 gccaactCTGCCTacaggg
 1
 AAGGCAGG m6b Disrupted 0.004000 no TS No effect
hsa-miR-2682-5p gccaactCTGCCTacaggg
 1
 CAGGCAGU m6b Disrupted -0.035 no TS 0.02
hsa-miR-3529-5p gccaacTCTACCTacaggg
 0 AGGUAGAC m7a Created NA NA No effect
hsa-miR-3927 gccaacTCTACCTacaggg
 0 CAGGUAGA m7b Created no TS -0.068 No effect
hsa-miR-4451 gccaaCTCTACCtacaggg
 0 UGGUAGAG m7b Created no TS -0.098 No effect
hsa-miR-4650-3p gccaacTCTACCTacaggg
 0 AGGUAGAA m7a Created NA NA No effect
hsa-miR-940 gccaactCTGCCTacaggg
 1
 AAGGCAGG m6b Disrupted 0.004 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53531837G>A COSN5224303 SS6003131 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-301a-5p tgtGTCAGAGtcaggggga
 2
 GCUCUGAC m7b (m7b->m6b) -0.009000 no TS 2.210000
hsa-miR-345-5p tgtgtcaGAGTCAGgggga
 6
 GCUGACUC m7b Disrupted -0.011000 no TS 4.730000
hsa-miR-4522 tgtgtCAGAGTCAggggga
 7
 UGACUCUG m8a Disrupted -0.068000 no TS 0.010000
hsa-miR-4714-5p tgtgTCAGAGTcaggggga
 2
 AACUCUGA m7b Disrupted 0.040000 no TS 2.000000
hsa-miR-4732-3p tgtgtcagaGTCAGGGgga
 3
 GCCCUGAC m7b (m7b->m6c) -0.043000 no TS 3.940000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53532247T>C COSN1747451 RK141_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5591-3p ttaggTGGGTAattatata
 16
 AUACCCAU m6b Disrupted -0.280000 -0.227000 0.140000
hsa-miR-5591-3p ttaggTGGGTAattatata
 19
 AUACCCAU m6b Disrupted -0.28 -0.227 0.14

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53532714T>A COSN9337789 AOCS-122-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4473 ttagGCACTAGacacccac
 0 CUAGUGCU m7a Created NA NA -0.010000
hsa-miR-519e-3p ttAGGCACTTgacacccac
 1
 AAGUGCCU m8a (m8a->m7a) -0.057000 -0.087000 -0.570000


Mutation Mutation ID Sample Name Cancer Type
chr18:g.53532821A>T COSN9337790 AOCS-096-1-7 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr18:g.53532948A>G COSN6127244 RK163_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-410 ggaaGTTATATTtctgctg
 3
 AAUAUAAC m8a Disrupted 0.270000 0.165000 -0.100000
hsa-miR-4803 ggaagTTATGTTtctgctg
 3
 UAACAUAA m7b Created 0.032000 0.190000 No effect
hsa-miR-494 ggaagttATGTTTCtgctg
 2
 UGAAACAU m7b Created 0.210000 0.305000 -0.210000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53533421G>A COSN9224715 8031157 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-192-3p tatTTGGCAGagcattctc
 2
 CUGCCAAU m7a (m7a->m6a) -0.143000 -0.146000 No effect
hsa-miR-3194-3p tatttgGCAGAGCattctc
 1
 AGCUCUGC m7b Disrupted -0.165000 -0.090000 No effect
hsa-miR-4727-5p tattTGGCAGAgcattctc
 4
 AUCUGCCA m7b Disrupted -0.129000 -0.114000 No effect
hsa-miR-4776-3p tattTGGCAAagcattctc
 6
 CUUGCCAU m6b Created -0.182000 -0.163000 No effect
hsa-miR-5691 tatttggCAGAGCAttctc
 2
 UUGCUCUG m7b Disrupted -0.014000 -0.027000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr18:g.53533480T>A 9_79652 CRC-7-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr18:g.53533829T>C COSN1747452 RK010_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr18:g.53534235C>T COSN7362847 8067075 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548aa ttaTGGTTTTggaatgtac
 0 AAAAACCA m7b (m6b->m7b) no TS 0.068000 -0.090000
hsa-miR-548ap-3p ttaTGGTTTTggaatgtac
 0 AAAAACCA m7b (m6b->m7b) no TS 0.068000 -0.120000
hsa-miR-548o-3p ttatgGTTTTGGaatgtac
 21
 CCAAAACU m7a Created -0.332000 -0.332000 No effect
hsa-miR-548t-3p ttaTGGTTTTggaatgtac
 0 AAAAACCA m7b (m6b->m7b) no TS 0.068000 -0.090000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53535029T>C COSN6665121 CHC322T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-128 atctCACTGTGtgctgaac
 15
 UCACAGUG m7b Disrupted -0.222000 -0.177000 3.170000
hsa-miR-3681-3p atctCACTGTGTgctgaac
 15
 ACACAGUG m8a Disrupted -0.258000 -0.166000 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53535231T>G COSN9840345 C0021T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-944 tttggATAATTTatgataa
 3
 AAAUUAUU m7a Disrupted 0.432000 0.432000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53535410C>A COSN7362848 8016498 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-183-3p ttttagggTAATTCAaaga
 18
 GUGAAUUA m7b Created 0.072000 0.013000 -0.230000
hsa-miR-4452 ttttagggtAATTCAAaga
 0 UUGAAUUC m7a (m6b->m7a) no TS 0.021000 -0.120000
hsa-miR-4725-5p ttttAGGGTCattcaaaga
 0 AGACCCUG m6b Disrupted -0.319000 -0.162000 No effect
hsa-miR-504 ttttAGGGTCattcaaaga
 0 AGACCCUG m6b Disrupted -0.354000 -0.204000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr18:g.53535886A>G COSN8680078 SS6003317 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1323 aataaataaAGTTTTGAta
 21
 UCAAAACU m8a (m8a->m7b) -0.311000 -0.089000 0.050000
hsa-miR-548a-3p aataaataaAGTTTTGata
 1
 CAAAACUG m7a (m7a->m6b) 0.330000 0.330000 0.010000
hsa-miR-548at-3p aataaataaGGTTTTGata
 0 CAAAACCG m7a (m6b->m7a) NA NA -0.210000
hsa-miR-548o-3p aataaataaAGTTTTGata
 21
 CCAAAACU m7b (m7b->m6c) -0.332000 -0.096000 0.010000
hsa-miR-5582-3p aataaataAAGTTTTgata
 21
 UAAAACUU m7b Disrupted 0.619000 0.737000 0.290000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
53530975 rs114935966 T T hsa-miR-570-3p
8
 tacctaTGTTTTC
 Disrupted
N
 -0.097
C hsa-miR-424-3p
6
 tacctACGTTTTc
 Created
N
 -0.098
53532319 rs147160815 - A hsa-miR-548av-3p
hsa-miR-548g-3p
0 CAGTTTAtttttt
CAGTTTAtttttt
 Unknown
Unknown
N
N
 0.027
0.037
- hsa-miR-548a-3p
hsa-miR-548ae
hsa-miR-548ah-3p
hsa-miR-548aj-3p
hsa-miR-548am-3p
hsa-miR-548aq-3p
hsa-miR-548ar-3p
hsa-miR-548az-3p
hsa-miR-548e-3p
hsa-miR-548f-3p
hsa-miR-548j-3p
hsa-miR-548x-3p
0 CAGTTTTttttt
cAGTTTTTtttt
cAGTTTTTtttt
cAGTTTTTtttt
cAGTTTTTtttt
cAGTTTTTtttt
CAGTTTTttttt
CAGTTTTttttt
CAGTTTTttttt
CAGTTTTttttt
cAGTTTTTtttt
cAGTTTTTtttt
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
N
N
N
N
N
 -0.041
0.06
0.069
0.06
0.069
0.06
-0.002
-0.015
-0.034
-0.041
0.069
0.06
53532710 rs114391898 C C hsa-miR-33b-3p
hsa-miR-515-3p
hsa-miR-519e-3p
hsa-miR-6513-3p
1
1
1
1
 cttAGGCACTtga
cttAGGCACTtga
cttAGGCACTtga
cttaggCACTTGA
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.047
-0.047
-0.057
0.091
T hsa-miR-1297
hsa-miR-26a-5p
hsa-miR-26b-5p
hsa-miR-4465
hsa-miR-5697
1
1
1
1
1
 cttaggTACTTGA
cttaggTACTTGA
cttaggTACTTGA
cttaggTACTTGA
cttaggTACTTGA
 Created
Created
Created
Created
Created
N
N
N
N
N
 0.13
0.111
0.111
0.149
0.105
53532793 rs2292043 T T hsa-miR-493-3p
hsa-miR-6126
hsa-miR-6864-5p
3
2
2
 acACCTTCAatct
acaCCTTCAAtct
acaCCTTCAAtct
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.004
0.032
0.019
C hsa-miR-3689d
hsa-miR-4443
hsa-miR-6515-5p
hsa-miR-6851-5p
3
2
2
3
 aCACCTCCAatct
acaCCTCCAAtct
acaCCTCCAAtct
aCACCTCCAatct
 Created
Created
Created
Created
N
N
N
N
 -0.163
-0.017
-0.015
-0.121
53533423 rs117620750 G G hsa-miR-3194-3p
hsa-miR-5691
hsa-miR-6805-3p
3
4
4
 gGCAGAGCAttct
ggCAGAGCAttct
ggCAGAGCAttct
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.075
0.013
0.031
A hsa-miR-4727-5p
hsa-miR-5001-3p
hsa-miR-6738-3p
4
4
4
 GGCAGAAcattct
GGCAGAAcattct
GGCAGAAcattct
 Created
Created
Created
N
N
N
 -0.04
-0.022
-0.057
53534235 rs139612928 C
T hsa-miR-548aa
hsa-miR-548ap-3p
hsa-miR-548t-3p
1
1
1
 TGGTTTTggaatg
TGGTTTTggaatg
TGGTTTTggaatg
 Created
Created
Created
N
N
N
 0.068
0.068
0.068
53534404 rs149778938 G G hsa-miR-3150a-5p
hsa-miR-3150b-5p
hsa-miR-3176
hsa-miR-3190-5p
hsa-miR-3922-3p
4
4
5
6
5
 aggccaGAGGTTA
aggccaGAGGTTA
AGGCCAGAggtta
aGGCCAGAggtta
AGGCCAGAggtta
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 0.024
0.024
-0.029
0.006
-0.018
A hsa-miR-6782-3p
hsa-miR-6878-3p
6
7
 aggcCAAAGGTta
AGGCCAAaggtta
 Created
Created
N
N
 0.095
0.001
53535029 rs16956878 T T hsa-miR-128-3p
hsa-miR-216a-3p
hsa-miR-3681-3p
15
15
15
 tCACTGTGtgctg
tCACTGTGtgctg
tCACTGTGtgctg
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.045
-0.064
-0.092

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