SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_052954
Gene Symbol:	CYYR1
Description:	Homo sapiens cysteine/tyrosine-rich 1 (CYYR1), mRNA.
Gene Location:	chr21(-):27838527-27945581
Browse Associations

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.26466618G>A			COSN6422521		HX36T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1468	aggaAAACGGAaaggaaag	0	CUCCGUUU	m7b	Disrupted	-0.377000	no TS	9.810000

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.26466974C>T			COSN5983787		RK081_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-488-3p	catatattaCTTTCAAata	3	UUGAAAGG	m7a	(m7a->m6a)	-0.034000	no TS	No effect
hsa-miR-548a-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.038000	no TS	0.720000
hsa-miR-548ab	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.038000	no TS	0.060000
hsa-miR-548ak	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.010000
hsa-miR-548am-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.020000
hsa-miR-548ap-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.047000	no TS	0.440000
hsa-miR-548aq-5p	catataTTACTTTCaaata	0	GAAAGUAA	m8a	Disrupted	-0.047000	no TS	0.210000
hsa-miR-548ar-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.050000
hsa-miR-548as-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.080000
hsa-miR-548au-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.050000
hsa-miR-548b-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.038000	no TS	0.230000
hsa-miR-548c-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.020000
hsa-miR-548d-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.038000	no TS	0.040000
hsa-miR-548h-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.030000
hsa-miR-548i	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.038000	no TS	0.210000
hsa-miR-548j	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.047000	no TS	0.050000
hsa-miR-548o-5p	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	0.020000
hsa-miR-548w	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.029000	no TS	No effect
hsa-miR-548y	catataTTACTTTcaaata	0	AAAAGUAA	m7b	Disrupted	-0.047000	no TS	0.010000
hsa-miR-559	catataTTACTTTcaaata	0	UAAAGUAA	m7b	Disrupted	-0.085000	no TS	0.910000
hsa-miR-5692a	catatATTATTTtcaaata	3	CAAAUAAU	m7b	Created	0.370000	0.434000	-0.030000
hsa-miR-5692b	catATATTATTttcaaata	2	AAUAAUAU	m8a	Created	0.072000	0.056000	-0.100000
hsa-miR-5692c	catATATTATTttcaaata	2	AAUAAUAU	m8a	Created	0.072000	0.056000	-0.100000

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.26467091G>C			COSN7142172		8057574		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1208	cccaaAACAGTGccaagaa	1	UCACUGUU	m7b	Disrupted	-0.049000	no TS	1.260000
hsa-miR-1271-5p	cccaaaacaGTGCCAAGaa	6	CUUGGCAC	m8a	(m8a->m7a)	-0.331000	-0.193000	0.240000
hsa-miR-34a-5p	cccaaaaCACTGCCAagaa	4	UGGCAGUG	m8a	Created	-0.073000	-0.360000	No effect
hsa-miR-34c-5p	cccaaaaCACTGCCaagaa	4	AGGCAGUG	m7b	Created	-0.063000	-0.361000	-0.190000
hsa-miR-449a	cccaaaaCACTGCCAagaa	4	UGGCAGUG	m8a	Created	-0.063000	-0.371000	-0.060000
hsa-miR-449b-5p	cccaaaaCACTGCCaagaa	4	AGGCAGUG	m7b	Created	-0.063000	-0.371000	-0.010000
hsa-miR-452-5p	cccaAAACAGTgccaagaa	1	AACUGUUU	m7b	Disrupted	-0.002000	no TS	0.280000
hsa-miR-4676-3p	cccaAAACAGTGccaagaa	1	CACUGUUU	m8a	Disrupted	-0.011000	no TS	0.400000
hsa-miR-548au-3p	cccaaaacACTGCCAagaa	4	UGGCAGUU	m7a	Created	-0.078000	-0.218000	No effect
hsa-miR-96-5p	cccaaaacaGTGCCAAgaa	6	UUUGGCAC	m7b	(m7b->m6b)	-0.359000	-0.202000	1.510000

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.26467467G>C			COSN5983788		RK212_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4539	ggaaatgaAGTTCAGattc	2	GCUGAACU	m7b	Disrupted	-0.181000	-0.091000	No effect
hsa-miR-573	ggaaatgaACTTCAGattc	1	CUGAAGUG	m7a	Created	-0.058000	-0.058000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.26467490G>A			COSN7142173		8033523		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-129-5p	aacagactcGCAAAAAtaa	2	CUUUUUGC	m7b	(m7b->m6b)	0.093000	0.058000	4.010000
hsa-miR-2113	aacagactCACAAAaataa	0	AUUUGUGC	m6b	Created	no TS	0.029000	-0.050000
hsa-miR-450a-5p	aacagacTCGCAAAAataa	0	UUUUGCGA	m8a	Disrupted	-0.257000	no TS	4.180000
hsa-miR-4737	aacagaCTCGCAaaaataa	0	AUGCGAGG	m6b	Disrupted	-0.161000	no TS	8.570000
hsa-miR-5010-3p	aacagactCACAAAAataa	0	UUUUGUGU	m7a	Created	no TS	0.043000	No effect
hsa-miR-627	aacAGACTCACaaaaataa	2	GUGAGUCU	m8a	Created	-0.168000	-0.212000	No effect
hsa-miR-758	aacagacTCACAAAaataa	0	UUUGUGAC	m7a	Created	no TS	-0.012000	-3.380000

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.26467659A>G			COSN7142174		8058339		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4762-3p	tagtggATCAGAAtaaagg	8	CUUCUGAU	m7b	Disrupted	-0.069000	-0.065000	0.400000
hsa-miR-4778-5p	tagtggatCAGAATaaagg	2	AAUUCUGU	m6b	Disrupted	0.009000	no TS	1.030000
hsa-miR-640	tagTGGATCAgaataaagg	1	AUGAUCCA	m7b	(m7b->m6c)	-0.110000	no TS	0.980000

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
26466511	rs150666754	G	G	hsa-miR-1269a hsa-miR-1269b hsa-miR-1288-3p hsa-miR-3138 hsa-miR-4515 hsa-miR-4539 hsa-miR-4724-5p hsa-miR-4740-5p hsa-miR-4800-5p	4 4 4 11 4 2 2 4 7	agttCAGTCCAca agttCAGTCCAca agttCAGTCCAca agttcaGTCCACA agttCAGTCCAca AGTTCAGtccaca aGTTCAGTccaca agtTCAGTCCAca agttcaGTCCACA	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.216 -0.216 -0.149 -0.14 -0.133 -0.091 -0.083 -0.353 -0.153
26466511	rs150666754	G	A	hsa-miR-203b-3p hsa-miR-3691-5p hsa-miR-376b-5p hsa-miR-376c-5p hsa-miR-4752 hsa-miR-7158-3p hsa-miR-8056	2 11 11 11 7 2 7	AGTTCAAtccaca agttcaATCCACA agttcaATCCACA agttcaATCCACA agttcaATCCACA AGTTCAAtccaca agttcAATCCACA	Created Created Created Created Created Created Created	N N N N N N N	-0.131 -0.099 -0.126 -0.126 -0.156 -0.067 -0.269
26467058	rs201508500	-	C	hsa-miR-1251-3p	0	atcaaaCAAAGCA	Unknown	N	-0.053
26467058	rs201508500	-	-	hsa-miR-129-5p hsa-miR-3140-3p	0	atCAAAAAAgca atcaaAAAAGCA	Unknown Unknown	N N	0.105 -0.006
26467463	rs219641	A	A	hsa-miR-4539	2	aAGTTCAGAttcc	Disrupted	N	-0.09
26467463	rs219641	A	G	hsa-miR-6716-3p	2	aAGTTCGGAttcc	Created	N	-0.372
26467466	rs76236577	T	T	hsa-miR-4539	2	atgaAGTTCAGAt	Disrupted	N	-0.09
26467466	rs76236577	T	C	hsa-miR-1199-5p hsa-miR-27b-5p hsa-miR-3200-5p hsa-miR-4303 hsa-miR-6751-3p	3 2 3 3 3	atgaaGCTCAGAt atgAAGCTCAgat atgaagCTCAGAT atgaaGCTCAGAt atgaaGCTCAGAt	Created Created Created Created Created	N N N N N	-0.069 -0.053 -0.009 -0.112 -0.069
26467665	rs144992751	T	T	hsa-miR-640	3	ttatagTGGATCA	Disrupted	N	-0.11
26467665	rs144992751	T	C	hsa-miR-4454	3	ttatagCGGATCA	Created	N	-0.166
26467787	rs77041278	G	G	hsa-miR-130b-5p	2	caGAAAGAGttgg	Disrupted	N	-0.127
26467787	rs77041278	G	C	hsa-miR-452-5p hsa-miR-4676-3p hsa-miR-892c-3p	2 2 2	cagAAACAGTtgg cagAAACAGTtgg cagAAACAGTtgg	Created Created Created	N N N	-0.017 -0.026 -0.026
26468065	rs182829858	C	C	hsa-miR-186-5p	9	ttcATTCTTTcat	Disrupted	N	-0.005
26468065	rs182829858	C	A	hsa-miR-5692a	9	ttcATTATTTcat	Created	N	0.048
26468472	rs151171541	A	A	hsa-miR-1271-5p hsa-miR-96-5p	6 6	GTGCCAAtgggcg GTGCCAAtgggcg	Disrupted Disrupted	N N	-0.193 -0.202
26468472	rs151171541	A
26468474	rs17002187	C	C	hsa-miR-1271-5p hsa-miR-96-5p	6 6	atGTGCCAAtggg atGTGCCAAtggg	Disrupted Disrupted	N N	-0.193 -0.202
26468474	rs17002187	C	T	hsa-miR-5682 hsa-miR-585-5p	6 6	atGTGCTAAtggg aTGTGCTAAtggg	Created Created	N N	-0.15 -0.354

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser