SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_017460 |
---|---|
Gene Symbol: | CYP3A4 |
Description: | Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), transcript variant 2, mRNA. |
Gene Location: | chr7(-):99354582-99381811 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757019C>G | COSN6901008 | RK121_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1324 |
caaCTGTCTGGatgcaatg |
0 | CCAGACAG | m8a | Created | no TS | -0.191000 |
-0.400000 |
|
hsa-miR-324-5p |
caactgtctGGATGCaatg |
0 | CGCAUCCC | m6b | Created | no TS | -0.194000 |
-0.530000 |
|
hsa-miR-4524a-3p |
caaCTGTCTCgatgcaatg |
1 |
UGAGACAG | m7b | (m7b->m6c) | -0.194000 | no TS |
13.770000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757072G>A | COSN6901009 | RK308_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-129-5p |
tgggagaCAAAAAacatgt |
0 | CUUUUUGC | m6b | Created | no TS | 0.059000 |
-0.100000 |
|
hsa-miR-3120-5p |
tgggAGACAGaaaacatgt |
1 |
CCUGUCUG | m6b | Disrupted | -0.109000 | no TS |
1.380000 |
|
hsa-miR-4652-3p |
tgggagACAGAAaacatgt |
1 |
GUUCUGUU | m6b | Disrupted | -0.063000 | no TS |
0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757181T>C | COSN5668159 | RK134_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3910 |
aaaaaaatATGCCTTTttg |
1 |
AAAGGCAU | m8a | Disrupted | -0.463000 | -0.197000 |
0.190000 |
|
hsa-miR-4484 |
aaaaaaataCGCCTTTTtg |
0 | AAAAGGCG | m8a | (m7a->m8a) | no TS | -0.265000 |
-0.040000 |
|
hsa-miR-548an |
aaaaaaataTGCCTTTTtg |
1 |
AAAAGGCA | m8a | (m8a->m7a) | -0.412000 | -0.168000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757254A>G | COSN6901010 | RK053_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-21-3p |
gggaggcgGGTGTTGaagt |
0 | CAACACCA | m7a | Created | NA | NA |
-1.290000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757433G>C | ICGC_7D69D4FE-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-106a-5p |
atcctaGCACTTTgggagg |
0 | AAAAGUGC | m7b | Created | -0.034 | -0.063 |
-3.23 |
|
hsa-miR-106b-5p |
atcctaGCACTTTgggagg |
0 | UAAAGUGC | m7b | Created | -0.034 | -0.044 |
-0.8 |
|
hsa-miR-17-5p |
atcctaGCACTTTGggagg |
0 | CAAAGUGC | m8a | Created | -0.034 | -0.063 |
-3.23 |
|
hsa-miR-186-3p |
atcctagcaCTTTGGGagg |
0 | GCCCAAAG | m7b | (m6b->m7b) | 0.003 | -0.141 |
-3.21 |
|
hsa-miR-20a-5p |
atcctaGCACTTTgggagg |
0 | UAAAGUGC | m7b | Created | -0.034 | -0.053 |
-2.99 |
|
hsa-miR-20b-5p |
atcctaGCACTTTGggagg |
0 | CAAAGUGC | m8a | Created | -0.034 | -0.053 |
-1.45 |
|
hsa-miR-302a-3p |
atcctAGCACTTtgggagg |
0 | UAAGUGCU | m7b | Created | no TS | -0.048 | No effect | |
hsa-miR-302b-3p |
atcctAGCACTTtgggagg |
0 | UAAGUGCU | m7b | Created | no TS | -0.048 | No effect | |
hsa-miR-302c-3p |
atcctAGCACTTtgggagg |
0 | UAAGUGCU | m7b | Created | no TS | -0.048 | No effect | |
hsa-miR-302d-3p |
atcctAGCACTTtgggagg |
0 | UAAGUGCU | m7b | Created | no TS | -0.048 | No effect | |
hsa-miR-302e |
atcctAGCACTTtgggagg |
0 | UAAGUGCU | m7b | Created | no TS | -0.039 | No effect | |
hsa-miR-372 |
atcctAGCACTTTgggagg |
0 | AAAGUGCU | m8a | Created | no TS | -0.067 |
-2.17 |
|
hsa-miR-373-3p |
atcctAGCACTTtgggagg |
0 | GAAGUGCU | m7b | Created | no TS | -0.067 | No effect | |
hsa-miR-519d |
atcctaGCACTTTGggagg |
0 | CAAAGUGC | m8a | Created | -0.048 | -0.077 | No effect | |
hsa-miR-520a-3p |
atcctAGCACTTTgggagg |
0 | AAAGUGCU | m8a | Created | no TS | -0.048 | No effect | |
hsa-miR-520b |
atcctAGCACTTTgggagg |
0 | AAAGUGCU | m8a | Created | no TS | -0.067 | No effect | |
hsa-miR-520c-3p |
atcctAGCACTTTgggagg |
0 | AAAGUGCU | m8a | Created | no TS | -0.067 | No effect | |
hsa-miR-520d-3p |
atcctAGCACTTTgggagg |
0 | AAAGUGCU | m8a | Created | no TS | -0.048 | No effect | |
hsa-miR-520e |
atcctAGCACTTTgggagg |
0 | AAAGUGCU | m8a | Created | no TS | -0.048 | No effect | |
hsa-miR-520g |
atcctagCACTTTGggagg |
0 | ACAAAGUG | m7b | Created | no TS | 0.038 |
-0.51 |
|
hsa-miR-520h |
atcctagCACTTTGggagg |
0 | ACAAAGUG | m7b | Created | no TS | 0.038 |
-0.06 |
|
hsa-miR-526b-3p |
atcctaGCACTTTgggagg |
0 | GAAAGUGC | m7b | Created | -0.044 | -0.073 |
-1.58 |
|
hsa-miR-548av-3p |
atcctaGCAGTTTgggagg |
0 | AAAACUGC | m7b | Disrupted | -0.042 | no TS |
0.46 |
|
hsa-miR-93-5p |
atcctaGCACTTTGggagg |
0 | CAAAGUGC | m8a | Created | -0.034 | -0.053 |
-1.61 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757438T>C | ICGC_7D69D9CC-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-204-3p |
ctgtaaTCCCAGCagtttg |
0 | GCUGGGAA | m7a | Created | NA | NA |
-0.01 |
|
hsa-miR-3159 |
ctgTAATCCTAgcagtttg |
0 | UAGGAUUA | m8a | Disrupted | -0.085 | no TS |
3.75 |
|
hsa-miR-3692-5p |
ctgtaatcCCAGCAGtttg |
0 | CCUGCUGG | m7b | Created | no TS | -0.127 |
-0.04 |
|
hsa-miR-5089 |
ctgtAATCCCAgcagtttg |
0 | GUGGGAUU | m7b | Created | no TS | -0.041 |
0.14 |
|
hsa-miR-5589-5p |
ctgtaatCCCAGCagtttg |
0 | GGCUGGGU | m6b | Created | no TS | -0.117 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757554G>T | COSN2246661 | RK189_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-10a-3p |
ctaGAATTTGattattaac |
0 | CAAAUUCG | m7a | (m7a->m6b) | NA | NA |
0.960000 |
|
hsa-miR-3163 |
ctagaATTTTATtattaac |
0 | UAUAAAAU | m7b | Created | no TS | 0.048000 | No effect | |
hsa-miR-369-3p |
ctagaatttTATTATTaac |
4 |
AAUAAUAC | m7a | (m6a->m7a) | -0.072000 | -0.072000 |
-0.010000 |
|
hsa-miR-5692b |
ctagaatttTATTATTaac |
5 |
AAUAAUAU | m7a | (m6a->m7a) | -0.087000 | -0.087000 |
-0.030000 |
|
hsa-miR-5692c |
ctagaatttTATTATTaac |
5 |
AAUAAUAU | m7a | (m6a->m7a) | -0.087000 | -0.087000 |
-0.030000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757763C>G | COSN5105813 | HX29T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99757885G>T | COSN2246663 | RK209_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-199a-5p |
gcttctCACTGGactattt |
0 | CCCAGUGU | m6b | Created | no TS | -0.112000 |
-11.760000 |
|
hsa-miR-199b-5p |
gcttctCACTGGactattt |
0 | CCCAGUGU | m6b | Created | no TS | -0.109000 |
-6.910000 |
|
hsa-miR-5190 |
gcttcTCACTGGactattt |
0 | CCAGUGAC | m7a | Created | NA | NA |
-10.960000 |
|
hsa-miR-5588-3p |
gcttctcacGGGACTattt |
1 |
AAGUCCCA | m6b | Disrupted | -0.161000 | no TS | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr7:g.99758009A>G | COSN1356295 | HCC58T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-491-3p |
acTGCATAAGtaaccgggg |
2 |
CUUAUGCA | m8a | (m7b->m8a) | -0.254000 | -0.107000 |
2.630000 |
|
hsa-miR-491-3p |
acTGCATAAGtaaccgggg |
2 |
CUUAUGCA | m8a | (m7b->m8a) | -0.254000 | -0.107000 |
2.630000 |
|
hsa-miR-491-3p |
acTGCATAAGtaaccgggg |
0 | CUUAUGCA | m8a | (m7b->m8a) | -0.254 | -0.107 |
2.63 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr7:g.99758103C>A | COSN1356296 | HCC94T | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-302b-5p |
tttgctcTTAAAGaaatct |
0 | ACUUUAAC | m6b | Created | no TS | -0.002000 |
-0.210000 |
hsa-miR-302d-5p |
tttgctcTTAAAGaaatct |
0 | ACUUUAAC | m6b | Created | no TS | 0.002000 |
-0.440000 |
hsa-miR-4635 |
tttgctCTTCAAGAaatct |
2 |
UCUUGAAG | m8a | Disrupted | -0.276000 | 0.011000 |
3.830000 |
hsa-miR-4709-3p |
tttgCTCTTCAAgaaatct |
0 | UUGAAGAG | m8a | Disrupted | -0.279000 | no TS |
1.050000 |
hsa-miR-526b-5p |
tttgctctTCAAGAaatct |
0 | CUCUUGAG | m6b | Disrupted | -0.103000 | no TS |
0.020000 |
hsa-miR-578 |
tttgctcttCAAGAAatct |
2 |
CUUCUUGU | m6b | Disrupted | -0.057000 | no TS |
0.040000 |
hsa-miR-302b-5p |
tttgctcTTAAAGaaatct |
0 | ACUUUAAC | m6b | Created | no TS | -0.002000 |
-0.210000 |
hsa-miR-302d-5p |
tttgctcTTAAAGaaatct |
0 | ACUUUAAC | m6b | Created | no TS | 0.002000 |
-0.440000 |
hsa-miR-4635 |
tttgctCTTCAAGAaatct |
2 |
UCUUGAAG | m8a | Disrupted | -0.276000 | 0.011000 |
3.830000 |
hsa-miR-4709-3p |
tttgCTCTTCAAgaaatct |
0 | UUGAAGAG | m8a | Disrupted | -0.279000 | no TS |
1.050000 |
hsa-miR-526b-5p |
tttgctctTCAAGAaatct |
0 | CUCUUGAG | m6b | Disrupted | -0.103000 | no TS |
0.020000 |
hsa-miR-578 |
tttgctcttCAAGAAatct |
2 |
CUUCUUGU | m6b | Disrupted | -0.057000 | no TS |
0.040000 |
hsa-miR-302b-5p |
tttgctcTTAAAGaaatct |
0 | ACUUUAAC | m6b | Created | no TS | -0.002 |
-0.21 |
hsa-miR-302d-5p |
tttgctcTTAAAGaaatct |
0 | ACUUUAAC | m6b | Created | no TS | 0.002 |
-0.44 |
hsa-miR-4635 |
tttgctCTTCAAGAaatct |
0 | UCUUGAAG | m8a | Disrupted | -0.276 | 0.011 |
3.83 |
hsa-miR-4709-3p |
tttgCTCTTCAAgaaatct |
0 | UUGAAGAG | m8a | Disrupted | -0.279 | no TS |
1.05 |
hsa-miR-526b-5p |
tttgctctTCAAGAaatct |
0 | CUCUUGAG | m6b | Disrupted | -0.103 | no TS |
0.02 |
hsa-miR-578 |
tttgctcttCAAGAAatct |
0 | CUUCUUGU | m6b | Disrupted | -0.057 | no TS |
0.04 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
99757885 | rs147937926 | G | G |
hsa-miR-2114-5p hsa-miR-5588-3p |
1 1 |
tctcacGGGACTA tctcacGGGACTA |
Disrupted Disrupted |
N N |
-0.175 -0.161 |
A |
hsa-miR-1914-5p hsa-miR-4540 hsa-miR-4677-3p hsa-miR-6838-3p |
1 1 1 1 |
tctCACAGGActa tctcacAGGACTA tCTCACAGgacta tctcaCAGGACTA |
Created Created Created Created |
N N N N |
-0.111 -0.166 -0.178 -0.363 |
|||
99758106 | rs192313684 | C | C |
hsa-miR-4635 hsa-miR-4709-3p |
10 3 |
tttgctCTTCAAG tttgCTCTTCAAg |
Disrupted Disrupted |
N N |
-0.212 -0.279 |
T |
hsa-miR-548e-5p |
2 |
ttTGCTTTTcaag |
Created |
N |
-0.113 |