SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001202855
Gene Symbol: CYP3A4
Description: Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), transcript variant 2, mRNA.
Gene Location: chr7(-):99354582-99381811
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757019C>G COSN6901008 RK121_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1324 caaCTGTCTGGatgcaatg
 0 CCAGACAG m8a Created no TS -0.191000 -0.400000
hsa-miR-324-5p caactgtctGGATGCaatg
 0 CGCAUCCC m6b Created no TS -0.194000 -0.530000
hsa-miR-4524a-3p caaCTGTCTCgatgcaatg
 1
 UGAGACAG m7b (m7b->m6c) -0.194000 no TS 13.770000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757072G>A COSN6901009 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-5p tgggagaCAAAAAacatgt
 0 CUUUUUGC m6b Created no TS 0.059000 -0.100000
hsa-miR-3120-5p tgggAGACAGaaaacatgt
 1
 CCUGUCUG m6b Disrupted -0.109000 no TS 1.380000
hsa-miR-4652-3p tgggagACAGAAaacatgt
 1
 GUUCUGUU m6b Disrupted -0.063000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757181T>C COSN5668159 RK134_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3910 aaaaaaatATGCCTTTttg
 1
 AAAGGCAU m8a Disrupted -0.463000 -0.197000 0.190000
hsa-miR-4484 aaaaaaataCGCCTTTTtg
 0 AAAAGGCG m8a (m7a->m8a) no TS -0.265000 -0.040000
hsa-miR-548an aaaaaaataTGCCTTTTtg
 1
 AAAAGGCA m8a (m8a->m7a) -0.412000 -0.168000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757254A>G COSN6901010 RK053_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-21-3p gggaggcgGGTGTTGaagt
 0 CAACACCA m7a Created NA NA -1.290000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757433G>C ICGC_7D69D4FE-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p atcctaGCACTTTgggagg
 0 AAAAGUGC m7b Created -0.034 -0.063 -3.23
hsa-miR-106b-5p atcctaGCACTTTgggagg
 0 UAAAGUGC m7b Created -0.034 -0.044 -0.8
hsa-miR-17-5p atcctaGCACTTTGggagg
 0 CAAAGUGC m8a Created -0.034 -0.063 -3.23
hsa-miR-186-3p atcctagcaCTTTGGGagg
 0 GCCCAAAG m7b (m6b->m7b) 0.003 -0.141 -3.21
hsa-miR-20a-5p atcctaGCACTTTgggagg
 0 UAAAGUGC m7b Created -0.034 -0.053 -2.99
hsa-miR-20b-5p atcctaGCACTTTGggagg
 0 CAAAGUGC m8a Created -0.034 -0.053 -1.45
hsa-miR-302a-3p atcctAGCACTTtgggagg
 0 UAAGUGCU m7b Created no TS -0.048 No effect
hsa-miR-302b-3p atcctAGCACTTtgggagg
 0 UAAGUGCU m7b Created no TS -0.048 No effect
hsa-miR-302c-3p atcctAGCACTTtgggagg
 0 UAAGUGCU m7b Created no TS -0.048 No effect
hsa-miR-302d-3p atcctAGCACTTtgggagg
 0 UAAGUGCU m7b Created no TS -0.048 No effect
hsa-miR-302e atcctAGCACTTtgggagg
 0 UAAGUGCU m7b Created no TS -0.039 No effect
hsa-miR-372 atcctAGCACTTTgggagg
 0 AAAGUGCU m8a Created no TS -0.067 -2.17
hsa-miR-373-3p atcctAGCACTTtgggagg
 0 GAAGUGCU m7b Created no TS -0.067 No effect
hsa-miR-519d atcctaGCACTTTGggagg
 0 CAAAGUGC m8a Created -0.048 -0.077 No effect
hsa-miR-520a-3p atcctAGCACTTTgggagg
 0 AAAGUGCU m8a Created no TS -0.048 No effect
hsa-miR-520b atcctAGCACTTTgggagg
 0 AAAGUGCU m8a Created no TS -0.067 No effect
hsa-miR-520c-3p atcctAGCACTTTgggagg
 0 AAAGUGCU m8a Created no TS -0.067 No effect
hsa-miR-520d-3p atcctAGCACTTTgggagg
 0 AAAGUGCU m8a Created no TS -0.048 No effect
hsa-miR-520e atcctAGCACTTTgggagg
 0 AAAGUGCU m8a Created no TS -0.048 No effect
hsa-miR-520g atcctagCACTTTGggagg
 0 ACAAAGUG m7b Created no TS 0.038 -0.51
hsa-miR-520h atcctagCACTTTGggagg
 0 ACAAAGUG m7b Created no TS 0.038 -0.06
hsa-miR-526b-3p atcctaGCACTTTgggagg
 0 GAAAGUGC m7b Created -0.044 -0.073 -1.58
hsa-miR-548av-3p atcctaGCAGTTTgggagg
 0 AAAACUGC m7b Disrupted -0.042 no TS 0.46
hsa-miR-93-5p atcctaGCACTTTGggagg
 0 CAAAGUGC m8a Created -0.034 -0.053 -1.61

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757438T>C ICGC_7D69D9CC-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-3p ctgtaaTCCCAGCagtttg
 0 GCUGGGAA m7a Created NA NA -0.01
hsa-miR-3159 ctgTAATCCTAgcagtttg
 0 UAGGAUUA m8a Disrupted -0.085 no TS 3.75
hsa-miR-3692-5p ctgtaatcCCAGCAGtttg
 0 CCUGCUGG m7b Created no TS -0.127 -0.04
hsa-miR-5089 ctgtAATCCCAgcagtttg
 0 GUGGGAUU m7b Created no TS -0.041 0.14
hsa-miR-5589-5p ctgtaatCCCAGCagtttg
 0 GGCUGGGU m6b Created no TS -0.117 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757554G>T COSN2246661 RK189_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10a-3p ctaGAATTTGattattaac
 0 CAAAUUCG m7a (m7a->m6b) NA NA 0.960000
hsa-miR-3163 ctagaATTTTATtattaac
 0 UAUAAAAU m7b Created no TS 0.048000 No effect
hsa-miR-369-3p ctagaatttTATTATTaac
 4
 AAUAAUAC m7a (m6a->m7a) -0.072000 -0.072000 -0.010000
hsa-miR-5692b ctagaatttTATTATTaac
 5
 AAUAAUAU m7a (m6a->m7a) -0.087000 -0.087000 -0.030000
hsa-miR-5692c ctagaatttTATTATTaac
 5
 AAUAAUAU m7a (m6a->m7a) -0.087000 -0.087000 -0.030000


Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757763C>G COSN5105813 HX29T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.99757885G>T COSN2246663 RK209_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-199a-5p gcttctCACTGGactattt
 0 CCCAGUGU m6b Created no TS -0.112000 -11.760000
hsa-miR-199b-5p gcttctCACTGGactattt
 0 CCCAGUGU m6b Created no TS -0.109000 -6.910000
hsa-miR-5190 gcttcTCACTGGactattt
 0 CCAGUGAC m7a Created NA NA -10.960000
hsa-miR-5588-3p gcttctcacGGGACTattt
 1
 AAGUCCCA m6b Disrupted -0.161000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99758009A>G COSN1356295 HCC58T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-491-3p acTGCATAAGtaaccgggg
 2
 CUUAUGCA m8a (m7b->m8a) -0.254000 -0.107000 2.630000
hsa-miR-491-3p acTGCATAAGtaaccgggg
 2
 CUUAUGCA m8a (m7b->m8a) -0.254000 -0.107000 2.630000
hsa-miR-491-3p acTGCATAAGtaaccgggg
 0 CUUAUGCA m8a (m7b->m8a) -0.254 -0.107 2.63

Mutation Mutation ID Sample Name Cancer Type
chr7:g.99758103C>A COSN1356296 HCC94T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-302b-5p tttgctcTTAAAGaaatct
 0 ACUUUAAC m6b Created no TS -0.002000 -0.210000
hsa-miR-302d-5p tttgctcTTAAAGaaatct
 0 ACUUUAAC m6b Created no TS 0.002000 -0.440000
hsa-miR-4635 tttgctCTTCAAGAaatct
 2
 UCUUGAAG m8a Disrupted -0.276000 0.011000 3.830000
hsa-miR-4709-3p tttgCTCTTCAAgaaatct
 0 UUGAAGAG m8a Disrupted -0.279000 no TS 1.050000
hsa-miR-526b-5p tttgctctTCAAGAaatct
 0 CUCUUGAG m6b Disrupted -0.103000 no TS 0.020000
hsa-miR-578 tttgctcttCAAGAAatct
 2
 CUUCUUGU m6b Disrupted -0.057000 no TS 0.040000
hsa-miR-302b-5p tttgctcTTAAAGaaatct
 0 ACUUUAAC m6b Created no TS -0.002000 -0.210000
hsa-miR-302d-5p tttgctcTTAAAGaaatct
 0 ACUUUAAC m6b Created no TS 0.002000 -0.440000
hsa-miR-4635 tttgctCTTCAAGAaatct
 2
 UCUUGAAG m8a Disrupted -0.276000 0.011000 3.830000
hsa-miR-4709-3p tttgCTCTTCAAgaaatct
 0 UUGAAGAG m8a Disrupted -0.279000 no TS 1.050000
hsa-miR-526b-5p tttgctctTCAAGAaatct
 0 CUCUUGAG m6b Disrupted -0.103000 no TS 0.020000
hsa-miR-578 tttgctcttCAAGAAatct
 2
 CUUCUUGU m6b Disrupted -0.057000 no TS 0.040000
hsa-miR-302b-5p tttgctcTTAAAGaaatct
 0 ACUUUAAC m6b Created no TS -0.002 -0.21
hsa-miR-302d-5p tttgctcTTAAAGaaatct
 0 ACUUUAAC m6b Created no TS 0.002 -0.44
hsa-miR-4635 tttgctCTTCAAGAaatct
 0 UCUUGAAG m8a Disrupted -0.276 0.011 3.83
hsa-miR-4709-3p tttgCTCTTCAAgaaatct
 0 UUGAAGAG m8a Disrupted -0.279 no TS 1.05
hsa-miR-526b-5p tttgctctTCAAGAaatct
 0 CUCUUGAG m6b Disrupted -0.103 no TS 0.02
hsa-miR-578 tttgctcttCAAGAAatct
 0 CUUCUUGU m6b Disrupted -0.057 no TS 0.04

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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