SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_031226
Gene Symbol:	CYP19A1
Description:	Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 1, mRNA.
Gene Location:	chr15(-):51500253-51630795
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51208422A>T			COSN1678698		RK165_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-181b-3p	taaattaTCAGTGAaatgc	6	CUCACUGA	m7b	Disrupted	-0.457000	-0.130000	0.770000
hsa-miR-27a-3p	taaattatCTGTGAAatgc	3	UUCACAGU	m7a	Created	-0.076000	-0.184000	-0.380000
hsa-miR-27b-3p	taaattatCTGTGAAatgc	3	UUCACAGU	m7a	Created	-0.076000	-0.184000	-0.150000
hsa-miR-4420	taaattaTCAGTGAaatgc	6	GUCACUGA	m7b	Disrupted	-0.503000	-0.176000	0.010000
hsa-miR-513a-5p	taaattatCTGTGAAatgc	3	UUCACAGG	m7a	Created	-0.085000	-0.192000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51208497G>A			COSN5398394		RK134_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4765	tgcttaaccATCACTCttg	0	UGAGUGAU	m7b	(m6b->m7b)	no TS	-0.144000	-0.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51208524T>C			COSN8174427		PCSI_0303_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-148a-5p	tcttcAGAACTTTgcccca	0	AAAGUUCU	m8a	Created	no TS	-0.046000	-0.760000
hsa-miR-148b-5p	tcttCAGAACTTtgcccca	0	AAGUUCUG	m8a	Created	no TS	-0.157000	-2.460000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51209104G>A			COSN7047718		8058330		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3924	cctgaATACATATgtagtc	0	AUAUGUAU	m8a	Created	no TS	0.041000	No effect
hsa-miR-5580-3p	cctgaataCATATGTagtc	0	CACAUAUG	m7b	Created	no TS	0.003000	0.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51209371G>C			COSN8746299		AOCS-152-1-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1976	tccctgaaaGCAGGAGcta	5	CCUCCUGC	m7b	(m7b->m6b)	-0.076000	no TS	3.450000
hsa-miR-29b-1-5p	tccctgAAACCAGgagcta	0	GCUGGUUU	m7b	Created	no TS	0.060000	No effect
hsa-miR-29b-2-5p	tccctGAAACCAGgagcta	5	CUGGUUUC	m8a	Created	-0.030000	0.019000	No effect
hsa-miR-3160-5p	tccctGAAAGCaggagcta	5	GGCUUUCU	m6b	Disrupted	0.069000	no TS	No effect
hsa-miR-370	tccctgaaAGCAGGagcta	5	GCCUGCUG	m6b	Disrupted	-0.022000	no TS	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51210002G>A			COSN6275179		RK123_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-373-3p	tcacatgatGCACTTCaaa	0	GAAGUGCU	m7a	(m7a->m6a)	NA	NA	0.530000
hsa-miR-519a-3p	tcacatgaTGCACTTcaaa	2	AAAGUGCA	m7b	Disrupted	-0.127000	no TS	5.250000
hsa-miR-519b-3p	tcacatgaTGCACTTcaaa	2	AAAGUGCA	m7b	Disrupted	-0.127000	no TS	5.140000
hsa-miR-519c-3p	tcacatgaTGCACTTcaaa	2	AAAGUGCA	m7b	Disrupted	-0.127000	no TS	6.630000
hsa-miR-595	tcacatgatACACTTCaaa	0	GAAGUGUG	m7a	(m6a->m7a)	NA	NA	-0.090000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

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